Recombinant Mouse Interleukin-24(Il24)

Code CSB-YP821683MO
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Source Yeast
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Code CSB-EP821683MO
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Source E.coli
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Code CSB-EP821683MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP821683MO
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Source Baculovirus
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Code CSB-MP821683MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Il24
Uniprot No. Q925S4
Alternative Names Il24; Mda7Interleukin-24; IL-24; IL-4-induced secreted protein; Melanoma differentiation-associated gene 7 protein; MDA-7; Th2-specific cytokine FISP
Species Mus musculus (Mouse)
Expression Region 27-181
Target Protein Sequence QEFR SGSCQVTGVV LPELWEAFWT VKNTVQTQDD ITSIRLLKPQ VLRNVSGAES CYLAHSLLKF YLNTVFKNYH SKIAKFKVLR SFSTLANNFI VIMSQLQPSK DNSMLPISES AHQRFLLFRR AFKQLDTEVA LVKAFGEVDI LLTWMQKFYH L
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.
Gene References into Functions
  1. our data suggest that IL-20 subfamily cytokines, particularly IL-20, IL-22, and IL-24, might provide therapeutic benefit for patients with Diabetic foot ulcers (DFU) . PMID: 28125663
  2. this study shows that IL-24 promotes Pseudomonas aeruginosa keratitis through the suppression of early protective mucosal immunity PMID: 28330899
  3. Loss of IL-24 expression is associated with breast cancer. PMID: 26460950
  4. A psoriasis-like skin inflammation in mice with epidermis-specific inhibition of NF-kappaB was triggered by TNFR1-dependent upregulation of interleukin-24 & activation of STAT3 signaling in keratinocytes. PMID: 24211183
  5. IL-24 suppresses the growth of normal vascular smooth muscle cells by inhibiting hydrogen peroxide-induced reactive oxygen species (ROS) production through the regulation of mitochondrial ROS production and expression of antioxidant enzymes PMID: 23052189
  6. Secretory mIL-24 did not induce the expression of the IL-6, TNF-alpha or IFN-gamma gene in spleen cells PMID: 22475191
  7. T cell receptor stimulation induces IL-24 expression in T helper type (Th)2 cells by the coordinate action of Stat6 and c-Jun transcription factors at the transcriptional level. PMID: 21357535
  8. induction of Il24 by oncogenes may support tumor growth at the early stages of cancer PMID: 15326486
  9. Grp170 enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24 PMID: 18483274
  10. the novel splicing variant of IL24, FISP-sp dimerizes with FISP and blocks its secretion and inhibits FISP-induced apoptosis in vivo PMID: 18708357
  11. Data demonstrated that IL-24 predominately stimulated neutrophils to produce IFN-gamma and IL-12, subsequently activating CD8+ T cells both in vivo and in vitro. PMID: 19830736

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Subcellular Location Secreted.
Protein Families IL-10 family
Tissue Specificity Selectively expressed by Th2 cells.
Database Links

KEGG: mmu:93672

STRING: 10090.ENSMUSP00000113064

UniGene: Mm.196691

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Address
7505 Fannin St. Ste 610-312, Houston, TX 77054, USA
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