Recombinant Mouse Keratin, type I cytoskeletal 18 (Krt18)

1. K18 deficiency of hepatocytes leads to steatosis, increasing with age, and finally to SH. K18 deficiency and age promote liver tumor development in mice, frequently on the basis of chromosomal instability, resembling human HCC with stemness features. PMID: 27689336
2. K8/K18-dependent PKCdelta- and ASMase-mediated modulation of lipid raft size can explain the more prominent FasR-mediated signaling resulting from K8/K18 loss. PMID: 27422101
3. autoantibodies were detected in aging K18-null male mice that had a related liver phenotype but normal colon compared with K8-null mice, suggesting that the autoantibodies are linked to liver rather than colonic disease PMID: 26399787
4. In human failing myocardium, where TNF-alpha expression is upregulated, K8/K18 were also ectopically expressed PMID: 26280121
5. The findings demonstrate the near complete loss of K8/K18 with concomitant high levels of vimentin in CT26 cells, a chemically-induced mouse colonic tumor. PMID: 25882495
6. in contrast to its importance as luminal cell marker, CK18 is dispensable for the prostate morphogenesis but contributes to adult prostate regeneration PMID: 24672777
7. Keratin 18 increases CFTR expression by binding to its C-terminal hydrophobic domain. PMID: 23045527
8. Oxidative stress, Nrf2 and keratin 18 up-regulation associate with Mallory-Denk body formation in mouse erythropoietic protoporphyria PMID: 22334478
9. Keratin 8 and keratin 18 mice on the same genetic background show similar sensitivity to DDC intoxication. PMID: 22449798
10. These findings reveal the potential for cytokeratin 18 to be used as a diagnostic marker for early detection of hepatosplenic schistosomiasis. PMID: 21357724
11. K18 glycosylation provides a unique protective role in epithelial injury by promoting the phosphorylation and activation of cell-survival kinases. PMID: 20729838
12. Krt18 may be a useful immunohistochemical marker for detecting hepatocellular proliferative lesions in mice. PMID: 20035116
13. Keratin 8 and keratin 18 play roles in regulating the shape and function of mitochondria. PMID: 19825937
14. Data show that inhibition of extracellular signal-regulated kinase 1 and 2 (ERK1/2) activation sensitizes wild-type but not keratin 8 (K8)-null mouse hepatocytes to apoptosis, and is associated with a reduction in c-Flip protein, part of a K8/K18 complex. PMID: 15282307
15. loss of the keratin cytoskeleton causes defects in the trophoblast giant cell layer PMID: 15819413
16. K18 overexpression protects mice from Mallory body (MB) formation and from DDC-induced liver injury, which supports the importance of the K8-to-K18 ratio in MB formation. PMID: 17187412
17. Study demonstrates here that, in the developing placenta of the mouse, the absence of the Mrj co-chaperone prevents proteasome degradation of keratin 18 intermediate filaments, resulting in the formation of keratin inclusion bodies. PMID: 17409114
18. study shows that dominant mutation hK18 R89C, leads to cell type-specific lethality in mice, depending on ratio of mutant to endogenous keratins; a single, endogenous K18 allele rescued embryonic lethality but caused aggregation of keratins PMID: 17617404
19. Keratin absence or mutation is well tolerated after pancreatic but not liver injury, whereas excessive overexpression is toxic to the pancreas but not the liver when induced under basal conditions. PMID: 18349119
20. Over expression of K18 R89C predisposes transgenic mice to thioacetamide- but not CCl(4)-induced liver fibrosis. PMID: 18395095
21. gene expression of krt8, krt18, and krt19 and correlation with gene expression profiles and cell differentiation are compared in human and mouse embryonic stem cells PMID: 18941637
22. Results suggest that the K8/K18 loss induces a switch in Fas-induced death signaling, likely through a DEDD involvement. PMID: 19002587
23. Resutls show that the appearance caspase-cleaved CK18 in plasma was found to reflect formation of the caspase-cleaved epitope in PMID: 19407366

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KEGG: mmu:16668

STRING: 10090.ENSMUSP00000023803

UniGene: Mm.22479