Recombinant Mouse Leukotriene B4 receptor 1 (Ltb4r), partial

1. Inhibiting the LTB4/BLT1 signaling pathway via AMPK activation is a potential treatment strategy for septic cardiac dysfunction because it efficiently attenuates cardiac apoptosis, which may occur via the inhibition of inflammation and mitochondrial dysfunction. PMID: 28290498
2. BLT1 signalling dampens the progression of APAP hepatotoxicity. PMID: 27404729
3. LTB4-BLT1 axis contributes to cisplatin-induced acute kidney injury by mediating kidney recruitment of neutrophils, which induce inflammation and apoptosis in the kidney. PMID: 28318626
4. These results demonstrate the importance of ATB2 cells in obesity-induced insulin resistance and suggest that inhibition of the LTB4/LTB4R1 axis might be a useful approach for developing insulin-sensitizing therapeutics PMID: 28192375
5. study demonstrates that the LTB4/BLT1 axis plays a critical role in acute injury phase to promote bleomycin -induced lung fibrosis, and it suggests that early interruption of the LTB4/BLT1 axis in some inflammatory diseases could prevent the later development of tissue fibrosis PMID: 28077599
6. This study demonstrates that LTB4 promotes macrophage phagocytosis of bacteria via BLT1, and that BLT2 can fulfill this role in the absence of BL PMID: 28053185
7. These results demonstrate a critical role for both BLT1 and CXCR3 in cytotoxic T lymphocyte (CTL) migration to tumors and thus may be targeted to enhance efficacy of CTL-based immunotherapies. PMID: 27465528
8. Our data show that LTB4 and its receptor BLT1 exacerbate synovial inflammation in vivo and bone resorption in vitro PMID: 27895169
9. the data show that the two leukotriene B4 receptors have opposing roles in the sensitization of peripheral sensory neurons forming a self-restricting system. PMID: 28242764
10. Our results highlight LTB4/BLT1 as absolutely critical drivers of murine pemphigoid disease-like skin inflammation. PMID: 28108297
11. Selective BLT1 inhibition with LSN2792613 reduces inflammation and apoptosis following IR, resulting in reduced IS, and therefore might be a promising strategy to prevent myocardial IR injury. PMID: 26449403
12. that Leukotriene B4-LTB4 receptor type 1 axis contributes not only to the peripheral inflammation but also to the neuronal activation in the spinal cord induced by intraplantar formalin injections PMID: 25889478
13. The results demonstrate that the LTB4 -BLT1 axis contributes to oxazolone-induced contact dermatitis by mediating skin recruitment of neutrophils, which are a major source of LTB4 that sequentially direct CD8(+) T-cell homing to oxazolone-challenged skin. PMID: 25959240
14. BLT1 and BLT2 are therefore potential targets for the development of novel drugs. PMID: 25480980
15. Low leukotriene B4 receptor 1 leads to ALOX5 downregulation at diagnosis of chronic myeloid leukemia. PMID: 25193960
16. Observations elucidate a novel role of the LTB4-Ltb4r1 signaling pathway in hepatocyte and myocyte insulin resistance. PMID: 25706874
17. The leukotriene B/BLT axis is a key determinant in susceptibility and resistance to histoplasmosis. PMID: 24465479
18. The LTB4-BLT signaling pathway provides a potent regulatory signal that accelerates the differentiation of mouse 3T3-L1 preadipocytes PMID: 23937951
19. Data indicate that LTB4 receptor type 1 (BLT1)-knockout mice showed delayed liver repair and a 70-80% attenuation in expression of epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), and VEGF receptor 1 (VEGFR1). PMID: 23629862
20. These results suggest that BLT1 expression on CD8 T cells plays an important role in their trafficking to tumors. PMID: 23960231
21. lipocalin OmCI ameliorates murine immune complex-induced acute lung injury in a process involving inhibition of LTB4 and C5 PMID: 23625922
22. Absence of LTB4/BLT1 signal transduction in BLT1-null mice facilitates generation of GM-CSF-induced long-lasting antitumor immunologic memory by enhancing innate and adaptive immune systems. PMID: 22936657
23. Signaling through its high-affinity G protein-coupled receptor leukotriene B4 receptor 1 (BLT1) directs dectin-1-dependent binding, ingestion, and cytokine production both in vitro and in vivo. PMID: 22696442
24. Identify the importance of the LTB4-BLT1 pathway in the development of late-phase, allergen-induced airway responsiveness after secondary airway challenge in mice with established airway disease. PMID: 21421908
25. a novel role of chemoattractant receptor, BLT-1, in promoting monocyte trafficking to adipose tissue and promoting chronic inflammation in obesity PMID: 21742977
26. Catalytic activity of Cyp4fs is a novel target for modulating neuroinflammation through hydroxylation of LTB(4). PMID: 21466787
27. Results identify LTB4-BLT1 as a potent nonchemokine pathway for cytotoxic effector cell traffic. PMID: 12949533
28. the LTB4-BLT1 axis mediates neutrophil infiltration and secondary injury in experimental spinal cord injury PMID: 20304963
29. Inflammation and bone erosion are absent in the knee joints of BLT1-deficient mice in an experimental arthritis model. PMID: 20656922
30. Attenuated Th1 induction by dendritic cells from mice deficient in the leukotriene B4 receptor 1 PMID: 20004699
31. BLT1 exacerbates experimental autoimmune encephalomyelitis by regulating the migration of inflammatory cells and T(H)1/T(H)17 immune responses. PMID: 20226760
32. gammadelta T cell migration into the pleural cavity of mice during diverse inflammatory responses is dependent on LTB(4)/BLT1. PMID: 19880577
33. bone resorption in was significantly attenuated in BLT1-deficient mice; furthermore, osteoclasts from BLT1-deficient mice showed reduced calcium resorption activities PMID: 19965376
34. 351 amino acid sequence determined and aligned with human sequence PMID: 12895595
35. The LTB4-BLT1 pathway is involved in linking early immune system activation and early effector T cell recruitment. PMID: 12949531
36. PMN activation; survival; and MPO levels and bacterial levels in liver, lung , and peritoneal fluid were compared in BLT1(-/-) mice and WT mice PMID: 15358656
37. BLT1 expression on primed T cells is required for the full development of airway hyperresponsiveness, which appears to be associated with IL-13 production in these cells. PMID: 15849325
38. BLT1, but not BLT2, receptor mRNA was expressed in the DRG. The results suggest the expression of functional BLT1 receptors in the sensory neurons. PMID: 15950785
39. model of acute lung rejection to demonstrate that BLT1 controls effector CD8+ T cell trafficking into the lung and that disruption of BLT1 signaling in CD8+ T cells reduces lung inflammation and mortality PMID: 15998790
40. BLT1 mediates early recruitment of granulocytes into the airway in response to antigen-antibody interactions in a murine model of acute asthma. PMID: 16126787
41. LTB4-BLT1 axis is required for the development of Th2-type immune response PMID: 16177061
42. An important role is defined for mast cells and the LTB4-BLT1 receptor pathway in the development of CD8+ T cell-mediated allergic responses in the lung. PMID: 16493075
43. expression of leukotriene b4 receptor is essential for development of airway hyperresponsiveness and inflammation through recruitment of IL-13 secreting CD8 positive T cells in mouse lung. PMID: 16522456
44. BLT1 enables the recruitment of additional neutrophils not expressing this receptor, thereby amplifying the inflammatory response in autoantibody-induced arthritis. PMID: 16567386
45. Disruption of BLT1 receptor is sufficient to offer complete protection of mice from developing arthritis in an inflammatory model. PMID: 16670336
46. demonstrates expression of functional Leukotriene B4 receptors, both BLT1 and BLT2, in murine and human mast cells and a regulatory role for stem cell factor in their expression PMID: 16920986
47. BLT1 contributes to the frequency and size of abdominal aortic aneurysms in mice. PMID: 17579092
48. Ser-127-Ala substitution of the PKC consensus phosphorylation site on the second intracellular loop prevented the BLT1 desensitisation. PMID: 17595524
49. LTB4/BLT1 pathway mediates hepatic microcirculatory dysfunction by enhanced expression of ICAM-1 and TNF-[alpha] in a murine model of endotoxemia. PMID: 18004232
50. BLT1 expression on dendritic cells (DCs) is required for migration of DCs to regional lymph nodes as well as in the development of airway hyperresponsivness and airway inflammation. PMID: 18606670

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KEGG: mmu:16995

STRING: 10090.ENSMUSP00000051368

UniGene: Mm.20853