Recombinant Mouse Lymphocyte cytosolic protein 2 (Lcp2)

1. Biochemical analyses revealed that mutant T cells were hypersensitive to TCR stimulation. Indeed, phosphorylation of several signaling proteins, including SLP76 itself, phospholipase Cgamma1 and the protein kinases AKT and ERK1/2, was increased PMID: 28107427
2. slp-76 contributes to the regulation of the tissue distribution, PLZF, and cytokine expression of iNKT cells via ADAP-dependent and -independent mechanisms. PMID: 27349342
3. findings identify ACK1 as a novel SLP-76-associated protein-tyrosine kinase that modulates early activation events in T cells. PMID: 28188290
4. immune cell adaptor SLP-76 binds directly to SUMO-RanGAP1 of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 and NF-kappaB p65 nuclear entry in T cells PMID: 26321253
5. these studies establish Slp-76 as a critical determinant of NK-cell development and NK cell mediated elimination of missing-self target cells in mice PMID: 25929249
6. Data show that a splice variant of SLP-76 signal transducing adaptor protein (SLP-76 or Lcp2) reduced the amount of SLP-76 protein by ~90%, disrupting immunogenic and tolerogenic pathways to different degrees. PMID: 25662996
7. A yopH mutant survived better in the absence of neutrophils, indicating that neutrophil inactivation by YopH by targeting PRAM-1/SKAP-HOM and SLP-76/Vav/PLCgamma2 signaling hubs may be critical for Yersinia survival. PMID: 24034616
8. analysis of a costimulatory mechanism by which CXCL12 and antigen converge at SLP-76 microcluster formation to enhance T cell responses PMID: 23901140
9. These findings reveal a novel role for SLP-76 in CXCR4-mediated T lymphocyte trafficking. PMID: 22806433
10. a novel regulation mechanism of SLP-76 by ubiquitination and proteasomal degradation of activated SLP-76, which is mediated by Ser-376 phosphorylation, leading to down-regulation of TCR signaling. PMID: 22902619
11. Loss of SLP-76 has no effect on persistence of the antigen-specific CD4+ memory pool, suggesting that homeostatic turnover is not required for persistence of this population. PMID: 22956580
12. SLP-76 and ADAP are involved in E-selectin-mediated integrin activation and neutrophil recruitment to inflamed kidneys, which may underlie the development of life-threatening ischemia-reperfusion-induced acute kidney injury in humans. PMID: 22291096
13. Data show that development of the CD8+ ILLs present in SH2 domain-containing leukocyte protein, 76-kDa Y145F mice require Eomes and PLZF. PMID: 21383242
14. Loss of Lcp2 leads to loss of tonic T-cell receptor signals altering the rate of memory versus effector cell differentiation independent of initial T-cell expansion. PMID: 20847203
15. Loss of Lcp2 leads to loss of tonic T-cell receptor signals altering the generation but not the persistence of CD8+ memory T cells. PMID: 20884806
16. HPK1 competes with ADAP for SLP-76 binding and via Rap1 negatively affects T-cell adhesion. PMID: 20957749
17. A nonhemostatic pathway in which platelet CLEC-2 receptors bind lymphatic endothelial PDPN and activate SLP-76 signaling to regulate embryonic vascular development. PMID: 20363774
18. Mice bearing membrane-targeted SLP-76 (MTS) have a partial T-cell lymphopenia and impaired signaling though the mature T-cell receptor. PMID: 20029045
19. Deletion of SLP-76 in polyclonal memory CD4 T cells leads to impaired steady-state homeostasis as well as impaired homeostatic responses to IL-7. PMID: 20080760
20. Differential role of SLP-76 domains in T cell development and function. PMID: 11792851
21. SLP-76 is required for signaling via the T cell antigen receptor (TCR) and pre-TCR. Platelet activation downstream of GPVI and alphaIIbbeta3 shows a dependency on SLP-76 PMID: 11901197
22. role of the adapter protein in GPVI-dependent platelet procoagulant responses to collagen PMID: 12351393
23. results support a non-cell-autonomous mechanism in which SLP-76 and Syk signals are required in circulating cells to regulate separation of blood and lymphatic vascular networks PMID: 12522250
24. Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells were elucidated PMID: 12640123
25. Study provides the first data to address the mechanisms controlling SLP-76 transcription by providing evidence for several key cis-regulatory elements in the promoter region. PMID: 14662865
26. bone marrow-derived macrophages mice lacking both SLP-76 and SLP-65 demonstrated normal FcgammaR-mediated activation PMID: 14694181
27. N-terminal tyrosines as well as the central proline-rich region of SLP-76 are required for participation of SLP-76 in FcepsilonRI-mediated signaling and function. PMID: 15153494
28. Results describe the effect of c-Cbl inactivation in mice deficient in the scaffolding molecule SLP-76. PMID: 15238603
29. ADAP-SLP-76 binding as a signaling event that differentially regulates SMAC formation, and support a role for SMAC formation in T cell cytokine production. PMID: 15477347
30. Tyr(145) of SLP-76 is the most critical tyrosine for both T cell function in vitro and T cell development in vivo PMID: 16456002
31. Both SH2 domains and the kinase domain of Syk are required for immunoreceptor-dependent signaling and cellular response via integrins. The Gads-binding domain of SLP-76 is needed for immunoreceptor signaling, but dispensable for integrin signaling. PMID: 16943434
32. Mouse embryos lacking Syk and Slp-76 develop abnormal blood-lymphatic endothelial connections. Expression of GFPSlp-76 rescues this phenotype, and that deficient cells confer focal vascular phenotypes in chimeric embryos. PMID: 16950126
33. SLP-76-deficient BMDCs adhere poorly to fibronectin, suggesting impaired integrin function and manifest signaling defects following integrin ligation, including reduced global tyrosine phosphorylation and markedly impaired phosphorylation of p44/42 MAPK PMID: 17015703
34. These data suggest that disruption of integrin signaling via loss of SLP-76 expression differentially impairs neutrophil functions in vivo. PMID: 17372019
35. Low SLP-76 expression correlated with reduced CD5 on immature thymocytes & reduced TCR signaling potential. Maintenance of sufficient SLP-76 expression from the endogenous locus is a key element in the thymic selection process. PMID: 17965338
36. SLP-76 acts as a dominant positive regulator for both NKG2D-mediated and YAC-1 cell-triggered IFN-gamma production PMID: 18203684
37. N-terminal tyrosines of SLP76 are required for thymocyte selection but can function on separate molecules to support TCR signaling PMID: 18342008
38. Using genetic complementation, all three phosphorylatable tyrosines are required within the same SLP76 molecule to support platelet activation by GPVI. PMID: 18663126
39. Cbl suppresses activation of a bypass signaling pathway and thereby enforces SLP76 dependence of early T cell development. PMID: 19074136
40. Fixed localization of SLP-76 reveals different requirements for subcellular localization of signal complexes downstream of the pre-T cell receptor (TCR) versus mature TCR; signaling requirements via pre-TCR and mature TCR overlap but are not identical. PMID: 19380761
41. the sterile-alpha motif (SAM) domain is indispensable for optimal SLP-76 signaling PMID: 19401562
42. SLP-76 is the dominant SLP family member in the osteoclast bone resorptive process cytoskeletal organization. SLP-76 is phosphorylated in a Syk-dependent manner PMID: 19592646
43. Y145 is the most critical tyrosine supporting SLP-76 function in myeloid cells. PMID: 19895996

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KEGG: mmu:16822

STRING: 10090.ENSMUSP00000126796

UniGene: Mm.265350