Recombinant Mouse Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA(Man1a1),partial,Mammalian cell

Code CSB-MP013383MO1
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Product Details

Purity >85% (SDS-PAGE)
Target Names Man1a1
Uniprot No. P45700
Alternative Names Man1a1; Man1aMannosyl-oligosaccharide 1,2-alpha-mannosidase IA; EC; Man(9)-alpha-mannosidase; Man9-mannosidase; Mannosidase alpha class 1A member 1; Processing alpha-1,2-mannosidase IA; Alpha-1,2-mannosidase IA
Species Mus musculus (Mouse)
Source Mammalian cell
Protein Length Partial
Tag Info N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Form Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2).
Gene References into Functions
  1. in the bound substrate complex, hydrophobic stacking interactions between Trp residues and the glycan core anchor the base of the glycan structure to the enzyme cleft PMID: 27856750
  2. Complex N-glycans generated by enzymes such as a-mannosidase I inhibit the activation of naive T cells. PMID: 21577142
  3. Data report the crystallization of murine Golgi mannosidase IA and the structural solution to 1.5-A resolution by molecular replacement PMID: 15102839
  4. Downregulation of TOAG-1 and alpha-1,2-mannosidase expression occurred in graft infiltrating cells and expression of both genes was also downregulated after T-cell activation in vitro PMID: 17456197
Subcellular Location Golgi apparatus membrane, Single-pass type II membrane protein
Protein Families Glycosyl hydrolase 47 family
Database Links

KEGG: mmu:17155

STRING: 10090.ENSMUSP00000003843

UniGene: Mm.117294


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