Recombinant Mouse Myc box-dependent-interacting protein 1 (Bin1)

1. Data (including data from studies using transgenic mice) suggest that the process leading to microparticle release from cardiac myocytes involves recruitment of CHMP4B protein to the forming microparticle membrane which also contains cBIN1; plasma cBIN1 is reduced in patients with heart failure as compared to control subjects. (CHMP4B = charged multivesicular body protein 4B; cBIN1 = cardiac bridging integrator 1) PMID: 28806752
2. Bin1 and CD2AP keep APP and BACE1 apart in early endosomes by distinct mechanisms in axon and dendrites. Individuals carrying variants of either factor would slowly accumulate Abeta in neurons increasing the risk for late-onset AD. PMID: 27895104
3. Data demonstrate that EHBP1L1 links Rab8 and the Bin1-dynamin complex, which generates membrane curvature and excises the vesicle at the endocytic recycling compartment for apical transport. PMID: 26833786
4. Findings show how cardiac deficiency in Bin1 function causes age- and stress-associated heart failure suggesting that Bin1 is a positive modifier of cardiac contractility that helps sustain adult heart function under stress conditions. PMID: 25939245
5. Reorganization of BIN1-induced microdomains recruits phosphorylated ryanodine receptors into dyads, increasing calcium signaling. PMID: 26733606
6. Bin1 mAb reduced colitis morbidity in mice while unprotected mice were characterized by severe lesions throughout the mucosa, rupture of lymphoid follicle, high-level neutrophil and lymphocyte infiltration into the mucosal areas, loss of surface crypts. PMID: 26195312
7. The release of BIN1 from hypo-poly(ADP-ribosyl)ated E2F1 is a mechanism by which serum starvation promotes E2F1-induced apoptosis. PMID: 25257171
8. BIN1 interacts with MTM1 in skeletal muscle. PMID: 23917616
9. Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia. PMID: 24836577
10. Bin1 is a genetic modifier of colitis that controls the paracellular pathway of transcellular ion transport regulated by cellular tight junctions. PMID: 22526583
11. Data have identified that membrane-associated BIN1 not only induces membrane curvature but can direct specific antegrade delivery of microtubule-transported membrane proteins. PMID: 20169111
12. BIN1 is transcriptionally activated by E2F1 and mediates E2F1-induced apoptosis in response to DNA damage. PMID: 19629135
13. findings support a role of the bilayer-deforming properties of amphiphysin at T-tubules and, more generally, a physiological role of amphiphysin in membrane deformation PMID: 12183633
14. Sorting nexin 4 and amphiphysin 2 have roles in endocytosis and intracellular trafficking PMID: 12668730
15. Bin1 has a developmentally critical role in cardiac muscle development PMID: 12773571
16. the results define a function for Bin1 in apoptosis that is conditional on transformation stress. PMID: 12789266
17. findings suggest that Bin1 loss promotes immune escape in cancer by deregulating indoleamine 2,3-dioxygenase (IDO) and that IDO inhibitors may improve responses to cancer chemotherapy PMID: 15711557
18. In mouse tumors, Bin1 ablation facilitated progression to more aggressive invasive status. PMID: 17699764
19. Bin1 displays protein scaffold-like properties and binds with sarcomeric factors important in directing sarcomere protein assembly and myofiber maturation. PMID: 19633357
20. Bin1 deletion elevated female reproductive capability until the age of 17.3 +/- 1.1 months and increased the incidence of lung cancer, liver cancer, and premalignant lesions in the prostate during aging. PMID: 17699764
21. Mammary specific deletion of Bin1 cooperates with carcinogen-induced ras activation to drive mammary tumor progression, establishing a role for Bin1 as a negative modifier of oncogenicity and progression in breast cancer. PMID: 17210688
22. Bin1 is upregulated in somites during muscle development; Bin1 induction in differentiation is required for p21WAF1 upregulation. PMID: 10036185

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KEGG: mmu:30948

STRING: 10090.ENSMUSP00000025239

UniGene: Mm.4383