Recombinant Mouse N-myc proto-oncogene protein (Mycn)

1. Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. PMID: 29636449
2. MYCN-promoted SGO1 transcription and SGO1 expression tended to be higher in MYCN- or MYC-overexpressing cancers. Together, these findings indicate that SGO1 plays a role in the DNA damage response in interphase. PMID: 27539729
3. we report the isolation and propagation of neuroblastoma sphere-forming cells with self-renewal and differentiation potential from tumors of the TH-MYCN mouse, an animal model of high-risk neuroblastoma with MYCN amplification PMID: 27705805
4. miR-34a contributes to the expansion of Myeloid-derived suppressor cells by inhibiting the apoptosis via suppressing the expression of N-myc. PMID: 26833183
5. the role of N-myc in mouse lens development, was examined. PMID: 28716713
6. Using comparative genomic hybridization, authors found that NCC-derived NBL tumors in mice acquired copy number gains and losses that are syntenic to those observed in human MYCN-amplified NBL including 17q gain, 2p gain and loss of 1p36. PMID: 28459463
7. a Mycn target gene encoding the miR cluster miR-17~92, while most retinoblastomas reemerged without clear genetic alterations in either Mycn or known Mycn targets. This Rb/MYCN model recapitulates key genetic driver alterations seen in human retinoblastoma and reveals the emergence of MYCN independence in an initially MYCN-driven tumor. PMID: 28165337
8. The findings reveal a PLK1-Fbw7-Myc signaling circuit that underlies tumorigenesis and validate PLK1 inhibitors, alone or with Bcl2 antagonists, as potential effective therapeutics for MYC-overexpressing cancers. PMID: 27773673
9. ALKR1275Q cooperated with MYCN in the development of aggressive NB, possibly by downregulating the expression of ECM/BM-associated genes and by conferring malignant potentials to MYCN-expressing cells. PMID: 26829053
10. Reuslts show that N-Myc overexpression leads to the development of poorly differentiated, invasive prostate cancer that is molecularly similar to human NEPC. PMID: 27728805
11. Thus, this synergistic effect of ZD55-shMYCN in combination with doxorubicin provides a novel therapy strategy for doxorubicin-resistant neuroblastoma, and is a promising approach for further clinical development. PMID: 28711493
12. Loss of N-myc significantly impairs the Sonic hedgehog signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2. PMID: 26238256
13. MYCN overexpression is not sufficient for these cells to form tumors in nude mice PMID: 26222553
14. MYCN plays a critical role in expansion and survival of aggressive medulloblastoma-propagating cells. PMID: 25785590
15. The results of this study provided evidence that N-myc deficiency in the olfactory epithelium progressively diminishes proliferation and neurogenesis with negative consequences at structural and cellular levels. PMID: 24376126
16. MYCN/LIN28B/Let-7/HMGA2 pathway implicated by meta-analysis of GWAS in suppression of post-natal proliferation thereby potentially contributing to aging PMID: 23639551
17. The above results induced by overexpression of MYCN closely resemble the main aspects of human AML, suggesting that MYCN plays a role in the etiology of AML. PMID: 23554972
18. a general mechanism for p53 inactivation in some embryonal cell types and consequent susceptibility to MycN oncogenesis at the point of embryonal tumor initiation PMID: 22907436
19. Epigenetic regulation of the neuroblastoma genes, Arid3b and Mycn. PMID: 22751132
20. a functional axis between MYCN and CDKL5 governing both neuron proliferation rate and differentiation. PMID: 22921766
21. Mycn acts downstream of BMP and NRG1 cardiogenic signaling pathways to promote normal myocardial wall morphogenesis. PMID: 23063798
22. Data have defined an important role for GCN5 in NSC and provided evidence that GCN5 is an important Myc transcriptional cofactor in vivo. PMID: 22745758
23. findings demonstrate a pathogenic role for ALK(F1174L) in neuroblastomas overexpressing MYCN and suggest a strategy for improving targeted therapy for ALK-positive neuroblastoma PMID: 22789543
24. Double deletion of c-Myc and N-Myc results in nearly complete loss of the residual pigmentation, indicating that N-Myc is capable of compensating for c-Myc loss of function in melanocytes. PMID: 22420299
25. Demonstrate context-dependent transformation of neural stem cells in response to common oncogenic signal N-MYC. PMID: 22624711
26. miRNAs expression in a mouse model (TH-MYCN/p53ER(TAM)) possessing a transgenic p53 allele that drives the expression of an inactive protein, miR-125b-3p and miR-676 were identified as directly or indirectly regulated by the level of functional p53 PMID: 22164278
27. Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma PMID: 22218692
28. N-Myc directly induced the transcription of the class III histone deacetylase SIRT1, which in turn increased N-Myc protein stability PMID: 21698133
29. N-Myc protein levels were increased in granule cell precursors in the presence of enforced Sna1 expression. N-Myc is a consistent target of Sna1. PMID: 21646478
30. Possible functional relationship of N-Myc with a number of other cell proliferative and fate determining genes during ear development. PMID: 21448975
31. Collectively, our data suggest that N-myc regulates growth, morphogenesis, and pattern formation during the development of the inner ear. PMID: 21562282
32. Site-directed mutagenesis of binding sites within the Pss1 promoter demonstrated that Sp and N-Myc synergistically activate Pss1 expression in astrocytes PMID: 21068393
33. Mycn is associated with acute lung injury PMID: 21297076
34. Data demonstrate that correct N-myc developmental expression is achieved via cooperation of multiple positive and negative regulatory elements, and include a specific role for the transcription factor GATA3. PMID: 20855530
35. Loss of Nmyc leads to severely disrupted self-renewal, pluripotency, and survival along with enhanced differentiation. PMID: 20537458
36. These results reveal that Wnt signaling via N-myc is crucial for the control of neuron number in the developing neocortex. PMID: 20215343
37. these findings identify Nmyc as a direct target of the Shh pathway that functions to regulate cell cycle progression in cerebellar granule neuron precursors. PMID: 12441288
38. Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors. PMID: 12777630
39. Shh and PI3K signaling pathways converge on N-Myc to regulate neuronal precursor cell cycle progression. PMID: 14660435
40. Essential in the developing lung for maintaining a distal population of progenitor cells. PMID: 15716345
41. N-myc is identified as a lipopolysaccharide- and interferon gamma-inducible gene that is involved in apoptotic autoregulation of microglial activation. PMID: 15953367
42. Our results indicate that forced expression of N-myc in the sensory lineage leads to unscheduled cell-cycle re-entry and excessive apoptosis and show that N-myc can affect the composition of different functional subtypes of sensory neurons in the DRG. PMID: 16133151
43. These results provide definitive genetic evidence that expression of N-Myc and concomitant down-regulation of Ink4c and Kip1 contribute to the proper development of the cerebellum. PMID: 16864777
44. N-myc is required for medulloblastoma genesis even in the presence of constitutively active signaling from the Shh pathway. PMID: 16951180
45. Defects in the formation of N-Myc-dependent interdigital tissue may be a root cause of common syndromic forms of syndactyly. PMID: 17360777
46. Nmyc is a regulator of genes involved in mRNA processing and a repressor of the imprinted gene Igf2r in the developing lung. PMID: 17486137
47. The Nmyc promoter can form a complex with Smad4 suggesting that Nmyc is a direct downstream target of Smad4 during cardiogenesis. PMID: 17585069
48. that BMP2 opposes Shh mitogenic activity by blocking Nmyc expression. We have identified TIEG-1 (KLF10) as the intermediary factor that blocks Nmyc expression through the occupancy of the Sp1 sites present in its promoter. PMID: 17951258
49. N-Myc overexpression is highly oncogenic in mouse myeloid cells PMID: 18006809
50. Huwe1 links destruction of N-Myc to the quiescent state that complements differentiation in the neural tissue PMID: 18488021

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KEGG: mmu:18109

STRING: 10090.ENSMUSP00000045993

UniGene: Mm.16469