Recombinant Mouse Neutrophil collagenase (Mmp8)

1. Suggest that Ang-(1-7) plays an important role in protecting against atherosclerosis via counter-regulation of Ang II-induced MMP-8. PMID: 28283184
2. MMP8 plays an important role in intestinal I/R injury through mechanisms involving increased inflammation and loss of claudin-3 PMID: 27435263
3. These results suggest that some of the anti-inflammatory effects of Dexamethasone are mediated through increased MMP-8 expression. PMID: 26923552
4. These results suggest a novel pathogenetic role of MMP8 and implicate modulation of its activity as a tractable strategy for therapies against cerebral ischemia. PMID: 25421209
5. Fusion peptide inhibitors of MMP-8/-9 prevent endotoxic shock if administered within a strict time window. PMID: 26111477
6. the loss of MMP-8 likely has pleiotropic effects on innate immunity and angiogenesis that are reflected in changes in the protease web. PMID: 25848906
7. A previously unknown role of MMP8 in M2-macrophage polarization by cleaving fibromodulin and therefore increasing the bioavailability of TGF-beta. PMID: 26092731
8. MMP-8-deficient mice had significantly lower serum triglyceride (TG) levels (P = 0.003) and larger HDL particles compared with wild-type (WT) mice. However, no differences were observed in the apoA-I levels. PMID: 25550459
9. These results demonstrate that MMP-8 critically mediates microglial activation by modulating TNF-alpha activity, which may explain neuroinflammation in septic mouse brain. PMID: 25049354
10. MMP8 enhances vascular smooth muscle cell proliferation via an ADAM10, N-cadherin, and beta-catenin-mediated pathway and plays an important role in neointima formation. PMID: 24158518
11. Suggest that MMP8 plays an important role in angiogenesis in vitro and in vivo. PMID: 23512982
12. MMP8 plays an important role in stem cell migration and their recruitment into atherosclerotic lesions. PMID: 23071158
13. These results show that MMP-8 can modulate the levels of S100A8 and S100A9 and its absence promotes the lung inflammatory response during endotoxemia. PMID: 22768176
14. Mmp-8 has a protective role in arthritis PMID: 21190566
15. MMP-8 is not essential for neutrophil migration in arthritis and likely other autoimmune diseases. Rather, MMP-8 is important for normal rates of neutrophil apoptosis and hence regulates cell clearance. PMID: 21120997
16. MMP-8 promotes acute inflammation after ventilation with high pressures, and its short-term inhibition could be a therapeutic goal to limit ventilator-induced lung injury. PMID: 19995943
17. MMP-8 potently reduces the accumulation of neutrophils and macrophages in the lungs of mice with lipopolysaccharide- and bleomycin-induced acute lung injury. PMID: 20042585
18. These results indicate that bradykinin at reperfusion triggers its cardioprotective signalling pathway through MMP-8-dependent transactivation of the EGFR. PMID: 19583703
19. In vitro, fewer MMP-8(-/-) PMNs migrated thru 3D cross-linked collagen gels than WT PMNs.This was likely a result of pericollagenase activity of MMP-8, as WT PMNs expressing MMP-8 could not migrate effectively thru collagen resistant to the collagenase. PMID: 19801498
20. immunohistochemistry of embryos between E9.5-E14.5 demonstrated MMP-8 expression in the surface ectoderm, neural crest cells and chondrocytes PMID: 11731274
21. highly elevated expression of MMP-8 (neutrophil collagenase) mRNA and protein in experimental autoimmune encephalomyelitis; colocalizing to neutrophil infiltrates found in brain and extensively in the spinal cord submeningeal space PMID: 11985514
22. protective role for Mmp8 in cancer and provides a genetic model to evaluate the molecular basis of gender differences in cancer susceptibility PMID: 14517555
23. membrane-bound MMP-8 accounts for 92% of the MMP-mediated, PMN surface type I collagenase activity PMID: 15187163
24. MMP-8 demonstrates an anti-inflammatory effect in allergic asthma and is implicated in the cascade of events leading to neutrophil apoptosis. PMID: 16081833
25. As seen in knockout mice, MMP-8 participates in wound repair by contributing to the resolution of inflammation and opens the possibility to develop new strategies for treating wound healing defects. PMID: 17392479
26. MMP-8 plays an important role in EAE development and propose that this enzyme may be a novel therapeutic target in human neuro-inflammatory diseases such as multiple sclerosis. PMID: 18245084
27. Loss of matrix metalloproteinase-8 is associated with tongue carcinogenesis PMID: 18253113
28. C-Jun-NH(2)-terminal kinase also involved in alveolo-capillary leakage and edema formation, whereas MMP8 inhibited alveolo-capillary protein leakage. PMID: 18270588
29. MMP-8 is a tumor protective factor, which also has the ability to reduce the metastatic potential of malignant cells in both mice and human. PMID: 18413742
30. MMP-8 regulates neutrophil migration through the extracellular matrix of the corneal stroma by generating chemotactic Pro-Gly-Pro during inflammation PMID: 18556780
31. study concludes that matrix metalloproteinase-8 cleaves IL-13 receptor alpha2 (IL-13R alpha 2) in vitro and contributes to the solubilization of IL-13R alpha 2 in vivo PMID: 18694590
32. MMP-8 appears to act in a protective manner inhibiting the development of bacterium-induced periodontal tissue destruction, possibly through the processing anti-inflammatory cytokines and chemokines. PMID: 19029300
33. Data suggest that antigen challenge via the airway activates Gr-1(+) cells and consequently MMP to facilitate the recruitment of Th cells in the airway inflammatory response. PMID: 19593770
34. Results indicate that MMP8 is an important player in atherosclerosis. PMID: 19745165

Show More

Hide All

KEGG: mmu:17394

STRING: 10090.ENSMUSP00000018765

UniGene: Mm.16415