Recombinant Mouse Nuclear factor of activated T-cells 5 (Nfat5), partial

1. TonEBP suppresses M2 phenotype via downregulation of the IL-10 in M1 macrophages. PMID: 27160066
2. Here the authors report a lipopolysaccharide-induced NFkappaB enhanceosome in which TonEBP is required for the recruitment of p300. Increased expression of TonEBP enhances the NFkappaB activity and reduced TonEBP expression lowers it. PMID: 27118681
3. Data suggest that protease 2A of CVB3 exhibits substrate specificity that includes human/mouse Nfat5 in cardiomyocytes; Nfat5 inhibits CVB3 replication via mechanism that involves iNOS; anti-CVB3 activity of Nfat5 is impaired during CVB3 infection due to protease 2A-mediated cleavage of Nfat5. (CVB3 = Coxsackievirus 3; Nfat5 = tonicity-responsive nuclear factor of activated T-cells 5; iNOS = nitric oxide synthase type II) PMID: 29220410
4. predominant role in promoting proinflammatory macrophage functions PMID: 29150563
5. NFAT5 can modulate different T-cell responses depending on stress conditions and stimulatory context. PMID: 27479742
6. results provide evidence that NFAT5 expression in macrophages enhances chronic arthritis by conferring apoptotic resistance to activated macrophages. PMID: 28192374
7. In vivo, osmotic stress up-regulates the SCTR gene in the kidney cortex and medulla of wild-type mice, but does not do so in NFAT5(+/-) mice. PMID: 27080132
8. TonEBP suppresses adipogenesis and insulin sensitivity by blocking epigenetic transition of PPARgamma2 PMID: 26042523
9. TonEBP is a critical regulator of neuroinflammation and blood-brain barrier leakage in kainic acid-induced seizures. PMID: 24608792
10. role in sodium-induced increase in monocytic cell adhesion PMID: 24573382
11. PKC-alpha contributes to high NaCl-dependent activation of NFAT5 through ERK1/2. PMID: 25391900
12. Suggest that biomechanical stretch is sufficient to activate NFAT5 both in native and cultured VSMCs where it regulates the expression of tenascin-C. PMID: 24614757
13. Together, these results clearly demonstrated that hyperglycemia-induced TonEBP plays a crucial role in increasing aldose reductase and PKCdelta levels and leading to apoptotic death. PMID: 24631337
14. Data indicate that in transgenic mice overexpressing Sfmbt2 10th intron-hosted miR-466a-3p, significant down-regulation of Nfat5 and many other osmoregulation-related genes was observed in both the renal cortex and medulla. PMID: 24389345
15. NFAT5 is part of a protective mechanism that limits renal damage induced by IRI. PMID: 24379188
16. NFAT5 induction by the pre-T-cell receptor serves as a selective survival signal in T-lymphocyte development. PMID: 24043824
17. A novel context-dependent suppression of NFAT5 target gene expression in RAW 264.7 macrophages stimulated with lipopolysaccharide (LPS) or a high salt (NaCl) concentration, was identified. PMID: 23867654
18. NFAT5 is necessary for the transcriptional regulation of AQP4 expression and for local astrocyte swelling with accompanying restriction of the neuropil extracellular space in vivo. PMID: 23180003
19. phosphorylated TAZ physically interacted with nuclear factor of activated T cells 5 (NFAT5), a major osmoregulatory transcription factor, and subsequently suppressed DNA binding and transcriptional activity of NFAT5 PMID: 23045390
20. These results demonstrated a novel role of NFAT5 in cardiac differentiation of stem cells. PMID: 22935419
21. Data indicate that transcriptional coregulator ddx5/ddx17 RNA helicases can simultaneously regulate the transcriptional activity and alternative splicing of NFAT5 transcription factor. PMID: 22266867
22. It was concluded that specific DNA binding of NFAT5 contributes to its nuclear localization, by mechanisms as yet undetermined, but independent of ones previously described. PMID: 22992674
23. Muscle fibers from type 1 diabetic mice exhibited increased NFAT5 expression and transverse tubule disruptions, but no differences in electrically evoked Ca(2+) transients. PMID: 22966145
24. NFAT5 was necessary for effective immunity against Leishmania major, a parasite whose clearance requires TLRs and iNOS expression in macrophages. PMID: 22312110
25. [review] TonEBP is required for mouse embryonic development and survival. TonEBP is a master regulator of cellular adaptation to hypertonic stress. PMID: 21998140
26. These findings demonstrated an essential role of NFAT5 in cardiac development and Ca(2+) signaling. PMID: 21765887
27. Identify NFAT5 as a novel regulator of vascular smooth muscle cell phenotypic modulation. PMID: 21757659
28. NFAT5-dependent CD24 induction contributes to T-cell expansion under hypertonic stress in a mouse model. PMID: 21037089
29. TonEBP is necessary for the regulation of AQP1 expression in the inner medulla of the kidney under hypertonic conditions. PMID: 20639513
30. The loss of nucleosome(s) was found to be initiated by an OREBP-independent mechanism, but was significantly potentiated in the presence of OREBP. PMID: 20041176
31. NFAT5 exclusion from mitotic chromatin resets its nucleo-cytoplasmic distribution in interphase PMID: 19750013
32. rottlerin dramatically inhibits tonicity-dependent TonEBP expression and TonE-dependent transcription but, does so through a PKCdelta-independent pathway. PMID: 11880333
33. TonEBP functions at all stages of mouse development, as well as in isotonic adult tissues PMID: 11934689
34. Data show that NFAT5/TonEBP stimulates transcription of HSP70-2, and is a master regulator of the renal medulla for cellular protection against high osmolality via organic osmolytes and molecular chaperones. PMID: 12138186
35. NFAT5 is important for cell growth in vivo and within the context of an isosmotic environment plays a role in optimally coordinating transcriptional programs in response to osmotic stresses to which cells are normally exposed in vivo during cell growth. PMID: 12421923
36. description of the complete sequence and primary structure of murine Nfat5, two new spliced isoforms, and the expression of murine Nfat5 in embryonic and adult mouse tissues PMID: 12438710
37. NFAT5 is a tonicity-responsive transcription factor required for kidney homeostasis and function; knockout mice show renal atrophy. PMID: 14983020
38. Data show that NFAT5/TonEBP is not only essential for normal cell proliferation under hyperosmotic conditions but also necessary for optimal adaptive immunity. PMID: 15247420
39. Data indicate that in addition to vasopressin, osmotic response element-binding protein (OREBP/Nfat5) is another essential regulator of the urine concentrating mechanism. PMID: 15347663
40. OREBP-mediated accumulation of osmolytes is essential during elongation of the lens fiber cells. PMID: 15774462
41. Identification of a noncoding RNA repressor of the nuclear factor of activated T cells (NFAT) activity. PMID: 16141075
42. TonEBP influences AQP2 transcriptional activity at least partially by acting directly on the AQP2 promoter PMID: 16641150
43. TonEBP, in turn, drives the expression of aldose reductase and urea transporter-A PMID: 16926446
44. myoblast migration and differentiation are coupled and that NFAT5 is a key regulator PMID: 17164296
45. NFAT5 not only plays an important role in osmotic stress response pathway in hybridoma cells but also is essential for optimal antibody productivity. PMID: 17310218
46. NFAT5 is a sensitive responder to pathologic increases in extracellular tonicity in T lymphocytes. PMID: 18221508
47. Nup88 is up-regulated in response to hypertonic stress and acts to retain TonEBP in the nucleus, activating transcription of critical osmoprotective genes. PMID: 18606815
48. an increase in intracellular ionic concentration and not cell shrinkage is involved in TonEBP activation PMID: 18842831
49. Results of these studies suggest that, in nucleus pulposus cells, osmotic pressure and calcium modulate AQP2 expression through TonEBP and are independent of the calcineurin-NFAT pathway PMID: 19138132
50. TonEBP activation by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc PMID: 19147493

Show More

Hide All

KEGG: mmu:54446

STRING: 10090.ENSMUSP00000119370

UniGene: Mm.390057