Recombinant Mouse Nuclear receptor subfamily 1 group I member 2 (Nr1i2)

1. Pregnane X receptor (PXR, NR1I2) is a crucial regulator of nutrient metabolism and metabolic detoxification. PXR senses xenobiotics and triggers the detoxification response to prevent diseases such as diabetes, obesity, intestinal inflammatory diseases and liver fibrosis. Review. PMID: 28534176
2. PXR deficiency suppresses chronic Ethanol-induced lipogenic gene induction. PMID: 29123032
3. Results demonstrate that PXR acts as a rheostat in fine tuning the balance of innate inflammatory pathways through TLR4 to ensure protective immunity. PMID: 27550658
4. Data suggest that regulation of SXR expression is involved in nephrosis induced by environmental poisons; here, nephrosis caused by atrazine herbicide poisoning can be mitigated by supplementation with antioxidant lycopene; in the kidney, mechanisms involved include modulation of SXR expression and of SXR transport to the nucleus. PMID: 29107825
5. Both the acetylation and SUMOylation status of the PXR protein is affected by its ability to associate with the lysine de-acetylating enzyme HDAC3 in a complex with SMRT. PMID: 26883953
6. The present study has revealed known and novel, as well as common and unique targets of PXR and CAR in mouse liver following pharmacological activation using their prototypical ligands. PMID: 27113289
7. FGF21-PXR signaling pathway may be involved in decreased hepatic CYP3A4 metabolic activity in Nonalcoholic fatty liver disease. PMID: 27482056
8. Pregnenolone 16alpha-carbonitrile has immunosuppressive activity independent of PXR activation to protect mice from immune-mediated liver injury induced by Con A. PMID: 28237809
9. carcinogens might trigger PXR in epidermal cells, particularly in Langerhans cells, leading to DNA damage PMID: 26013842
10. PXR activation stimulates EGF-mediated hepatocyte proliferation in mice, at least in part, through inhibiting FOXO3 from accelerating cell-cycle progression. PMID: 26574435
11. The role of intestinal PXR in linking xenobiotic exposure and hyperlipidemia. PMID: 25811240
12. modulation of vemurafenib bioavailability through pregnane X receptor-mediated regulation of drug transporters has the potential to markedly influence systemic exposure and thereby therapeutic outcomes. PMID: 26363009
13. results indicate that SXR/PXR protects against aging-dependent wearing of articular cartilage and that ligands for SXR/PXR have potential role in preventing osteoarthritis caused by aging. PMID: 25749104
14. Suggest a novel role for PXR signaling in the maintenance of intestinal homeostasis and may help to elucidate additional mechanisms through which PXR signaling is protective in inflammatory bowel disease. PMID: 24486481
15. a direct chemical communication between the intestinal symbionts and PXR regulates mucosal integrity through a pathway that involves luminal sensing and signaling by TLR4. PMID: 25065623
16. Role of pregnane X receptor in obesity and glucose homeostasis PMID: 24362030
17. Xenobiotic-induced hepatocyte proliferation mediated by CAR or PPARalpha is enhanced by PXR co-activation despite the fact that PXR activation alone does not cause the cell proliferation in mouse livers. PMID: 23626729
18. Results indicate that pregnane X receptor (PXR) represents a flow-activated detoxification system to protect endothelial cells (ECs) against damage by xeno- and endobiotics. PMID: 23878263
19. Study reveals that alpha-tocopherol is a partial agonist of PXR and that PXR is necessary for Cyp3a induction by alpha-tocopherol in Pxr-null and PXR-humanized mice. PMID: 23160821
20. Activation of PXR effectively inhibited the development of bleomycin-induced dermal fibrosis and induced the regression of established dermal fibrosis as assessed by skin thickening, hydroxyproline content and myofibroblasts. PMID: 23291432
21. PXR expression remained unchanged by hypothyroidism PMID: 22503787
22. PXR is a key regulator of pregnancy induced glucuronidation capacity in addition to modulating the severity of neonatal jaundice. PMID: 22371261
23. CAR and PXR are closely associated and have diverse roles, both as positive and negative regulators of hepatic genes PMID: 22698814
24. a unique role for SXR as a modulator of developmental hematopoiesis in the liver. PMID: 22496360
25. Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress. PMID: 22166712
26. Results provide a way to development of a dual PXR agonist/FXR antagonist with a robust immunomodulatory activity and endowed with the ability to modulate the expression of bile acid-regulated genes in the liver. PMID: 22285937
27. Data show that pregnane X receptor (PXR) deficiency did not alter plasma lipid levels in apoE(-/-) mice, but PXR(-/-)apoE(-/-) mice had significantly decreased atherosclerotic cross-sectional lesion area. PMID: 21685500
28. Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice PMID: 21747170
29. These results demonstrate a novel and unsuspected role for steroid and xenobiotic receptor (SXR) signaling in the B-1 cell compartment, establish SXR as a tumor suppressor in B-1 cells PMID: 21436254
30. PXR prevented choelsterol gallstone disease via its coordinate regulation of the biosynthesis and transport of bile salts in the liver and intestine. PMID: 21354151
31. analysis of hepatic transcriptional responses of wild-type (PXR(+/+)) and pregnane X receptor-knockout (PXR(-/-)) mice after 96 h exposure to CMP013, an inhibitor of beta-secretase PMID: 21203578
32. investigation of role of PXR in regulation of gene expression regulation of placental drug transporters; results suggest a tissue-specific role for gene regulation by PXR PMID: 21127142
33. Pregnane X receptor promotes bone formation and suppresses bone resorption, thus cementing a role for pregnane X receptor as a key regulator of bone homeostasis. PMID: 20876238
34. studies demonstrate that the variant PXR isoform, mPXR(Delta171-211), has a distinct repressive function from mPXR(431) in regulating genes encoding important drug metabolizing enzymes and transport proteins PMID: 20060928
35. PXR activation inhibits T cell proliferation and interferon (IFN)-gamma production and expression in vitro. PMID: 20173028
36. loss of pregnane X receptor (PXR) potentiates lipopolysaccharide/D-galactosamine-induced hepatocyte apoptosis and liver injury PMID: 19997066
37. Pxr plays only a limited role in mediating responses to gut-derived lithocholic acid PMID: 19797606
38. PXR-null mice show inherited phenotype of hypophosphatemia and severe repression of Na/Pi cotransporter NaPi-IIb/Npt2b (SLC34A2) PMID: 19898264
39. Reduction in cytochrome p-450 enzyme expression is associaated with repression of PXR PMID: 12054576
40. PXR serves as a master regulator of the phase I and II responses to facilitate rapid and efficient detoxification and elimination of foreign chemicals. PMID: 12370413
41. mouse PXR requires a specific agonist different from that required in humans to induce cyp3A expression PMID: 12569201
42. PXR was retained in the cytoplasm of hepatic cells of untreated mice, whereas it was translocated to the nucleus after administration of a ligand; results provide evidence that nuclear import is mediated by bipartite type of nuclear localization signal PMID: 12606758
43. HNF4alpha is the key transcription factor regulating responses to xenobiotics through activation of the PXR gene during fetal liver development. PMID: 12774017
44. identified a drug-responsive enhancer in the ALAS1 gene activated by the pregnane X receptor and the constitutive androstane receptor PMID: 12881517
45. farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor protect against hepatic bile acid toxicity in a complementary manner, preventing overt hepatic damage by bile acids during cholestasis PMID: 12923173
46. Lipopolysaccharide induced downregulation of nuclear Pregnane X receptor in mouse liver PMID: 15183191
47. FOXO1 was found to be a coactivator to CAR- and PXR-mediated transcription. PMID: 15340055
48. cytoplasmic constitutive active/androstane receptor retention protein mediates the retention of PXR in the cytosol and modulates the activation of PXR in response to Pregnenolone Carbonitrile treatment PMID: 15347657
49. CAR and PXR function coordinately to regulate both xenobiotic and bile acid metabolism PMID: 15358766
50. PXR plays a role in the down-regulation of several hepatic proteins during inflammation PMID: 15456840

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KEGG: mmu:18171

STRING: 10090.ENSMUSP00000023504

UniGene: Mm.8509