Recombinant Mouse Nucleotide-binding oligomerization domain-containing protein 1 (Nod1), partial

1. the absence of Nod1 does not impair the recruitment of neutrophils in response to P. aeruginosa PMID: 29450586
2. These findings reveal macrophage NOD1 as a cell-specific target to combat diet-induced inflammation past the step of macrophage infiltration, leading to insulin resistance. PMID: 28273456
3. Results show that the simultaneous absence of Nod1 and Nod2 is associated with accelerated T cell death upon alloantigen encounter, suggesting these proteins might provide new targets to ameliorate T cell responses in a variety of inflammatory states, including those associated with bone marrow or solid organ transplantation. PMID: 28652394
4. this study shows that the effect of the gut microbiota on bone is dependent on NOD1 and NOD2 signaling PMID: 28576260
5. we propose that NOD1 signaling in mesenchymal stromal cells serves as an important pathway underlying the requirement for microbiota in the maintenance of steady-state hematopoiesis PMID: 27799160
6. results suggest a previously unappreciated role for the innate immune receptor Nod1 in suppressing colitis-associated tumorigenesis through a T cell-mediated mechanism PMID: 27183588
7. NOD1 activation in cardiac fibroblasts induces myocardial fibrosis in a murine model of type 2 diabetes. PMID: 27803247
8. this study reveals that LRRK2 is a new positive regulator of Rip2 and promotes inflammatory cytokine induction through the Nod1/2-Rip2 pathway. PMID: 27830463
9. this paper shows that deletion of NOD1 aggravated bone resorption induced by Gram-negative bacteria, accompanied by an increase in the numbers of osteoclasts PMID: 27479869
10. Sertoli cells have a functional NALP3 inflammasome that modulates NOD1 and pro-IL-1beta expression, while NOD2 inversely promoted IL-1beta expression. PMID: 26744177
11. contributes to fetal growth retardation and death through vascular inflammation PMID: 26880761
12. The results indicate that Nod1 cooperates with Nod2 or TLRs to produce cytokines in macrophages in response to M. tuberculosis infection. PMID: 26255090
13. findings illuminated a role for NOD1 signaling in attenuating H. pylori-induced Cdx2 expression in gastric epithelial cells PMID: 26759244
14. NOD1 and NOD2, play a collaborative role in T cell activation by alloantigen and that their blockade in vitro can inhibit T cell responses. PMID: 26159289
15. NOD1 and NOD2, two members of the NOD-like receptor family of pattern recognition receptors, are important mediators of ER-stress-induced inflammation in mouse and human cells PMID: 27007849
16. NOD1 activation induces cardiac dysfunction associated with excitation-contraction coupling impairment through NF-kappaB activation. PMID: 25824149
17. Activation of NOD1 by DAP contributes to reperfusion injury via multiple signaling pathways. PMID: 25608996
18. Nod1 levels (and Nod2) in osteoclastogenesis are influenced by MyD88 signaling. PMID: 25125146
19. Data show that NOD1 or NOD2 synergizes with TLR4 in exacerbating the immune, sickness and brain responses to immune stimulation. Interactions of NLRs and TLRs at the immune cell level extend to interactions affecting brain function and behavior. PMID: 25218901
20. NOD1 and TLR4 signaling act synergistically to mobilize hematopoietic stem cells during bacterial infection. PMID: 24882704
21. Bacterial peptidoglycan stimulates adipocyte lipolysis via NOD1. PMID: 24828250
22. data show that Nod1, Nod2 and Rip2 are not required for local chemokine production and neutrophil recruitment during CLP-induced sepsis, and they reinforce the importance of MyD88-dependent signaling for initiation of a protective host response. PMID: 25084278
23. Data in the present study show that the Nod1 signaling pathway in non-bone marrow-derived cells contributes to the development of atherosclerosis. PMID: 25488987
24. NOD1 has an active role in the heightened inflammatory environment associated with both experimental murine and human diabetic cardiac disease. PMID: 24934088
25. NOD1 activation reduced AHR in allergen-induced lung inflammation. PMID: 24279792
26. In mice, systemic NOD1 ligation exacerbated allergen-induced experimental asthma by amplifying CCL17-mediated Th2 responses in the lung. PMID: 24661094
27. Activation of NOD1 induces lipolysis through NF-kappaB and the lipolytic PKA activation in 3T3-L1 adipocytes. PMID: 24219284
28. Data indicate that a CCR6/CCL20 chemokine loop instructed rapid increase of B cells in the spleen in response to systemic administration of Nod1 agonists in a TNF-alpha-dependent manner. PMID: 24534531
29. necessary within dendritic cells for optimal IFN-gamma production by iNKT cells, as well as NK cells PMID: 24163408
30. Activation of NOD1, but not NOD2, by a synthetic ligand dose-dependently suppressed 3T3-L1 adipocyte differentiation as revealed by lipid accumulation, and attenuated gene expression of adipocyte markers (PPARgamma, C/EBPalpha, SCD, FABP4, Adiponectin). PMID: 23712977
31. These results suggest that cooperation of NOD and TLR receptors is important for effective responses to microbial infection in vivo. PMID: 23897616
32. Authors report that Nod1, an innate intracellular host receptor for bacterial peptidoglycan-related molecules, is critical for commensal-induced periodontitis in a mouse model. PMID: 23684310
33. Cyclosporine A impairs nucleotide binding oligomerization domain (Nod1)-mediated innate antibacterial renal defenses in mice and human transplant recipients. PMID: 23382681
34. These data suggest that Nod1 stimulation is an important inducer of CNV and that Nod1 might be useful in the development of CNV therapies. PMID: 23328697
35. data identify the activation of small Rho GTPases as a pathogen-induced process sensed through the NOD1 signalling pathway PMID: 23542589
36. NOD1 activation induces cardiac dysfunction and modulates cardiac fibrosis and cardiomyocyte apoptosis. PMID: 23028889
37. NOD1 might function as an alternative costimulatory receptor in CD8 T cells PMID: 22848741
38. Sensing of commensal organisms by the intracellular sensor NOD1 mediates experimental pancreatitis. PMID: 22902233
39. Nod1 and Nod2 play important roles in the innate immune response of prostate epithelial cells and the development and progression of prostate cancer. PMID: 22228081
40. NOD1, NOD2 and Rip2 are dispensable for the control of B. abortus during in vivo infection. PMID: 22203860
41. SipA triggered mucosal inflammation in wild-type mice but not in NOD1/NOD2-deficient mice, thus SipA-driven activation of the NOD1/NOD2 signaling pathway as a mechanism by which the type III secretion system induces inflammatory responses. PMID: 22186610
42. NOD1 may play an important role in adipose inflammation and insulin resistance in diet-induced obesity. PMID: 21693690
43. Following trophoblast treatment with gram-negative bacterial agonist of Nod1, there is a significant response characterized by elevated levels of maternal-fetal proinflammatory cytokines, triggering preterm labor in a murine model. PMID: 21677137
44. Viral Infection Augments Nod1 and Nod2 Signaling and enhances the production of proinflammatory cytokines. PMID: 21669398
45. Results indicate that Nod1 regulates host susceptibility to C. difficile and suggest that Nod1-mediated neutrophil recruitment is an important immune response against the enteric pathogen. PMID: 21411735
46. NOD1 and NOD2 activation induces an analgesic effect via opioid receptors in a TNF-alpha and IL-1alpha/beta independent manner. PMID: 20083500
47. Report coronary arteritis animal model induced by oral administration of a pure synthetic Nod1 ligand. PMID: 21330608
48. knock-outs display impaired bacterial clearance upon infection with aerosolized Legionella pneumophila PMID: 21108472
49. suggest an important role for hepatocyte NOD1 in attracting leukocytes to the liver PMID: 20615568
50. These studies show that Nod1, Nod2, and Rip2 account for generation of innate immune responses in vivo, which are important for NE recruitment and bacterial clearance in a murine model of Legionnaires diseases. PMID: 20685341

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KEGG: mmu:107607

STRING: 10090.ENSMUSP00000055747

UniGene: Mm.28498