Recombinant Mouse Perilipin-2 (Plin2)

1. Genetic ablation of Plin2 in Akita mice leads to mitigation of ER stress, forestalling beta cell apoptosis, partially restoring beta cell mass, and ameliorating diabetes. PMID: 28102311
2. Lipid-laden fibroblasts (lipofibroblasts) express the Perilipin 2 (Plin2) gene-product, PLIN2, commonly called adipose-differentiation related protein (ADRP)..The present study reports the generation of an inducible mouse Cre-driver line to target cells of the ADRP lineage. Robust Cre-mediated recombination in this mouse line was detected in mesenchymal cells of the postnatal lung PMID: 29045046
3. Plin2 is essential for protecting the pool of skeletal muscle lipid droplet PMID: 28822960
4. PLIN2 overexpression protects against autophagy, and its downregulation stimulates triglyceride catabolism via autophagy. PMID: 28548876
5. data shows that a host genotype can modulate microbiome function without impacting community structure and identify Plin2 as a specific host determinant of diet effects on microbial function. PMID: 28877764
6. ADRP knockdown significantly inhibited PDGFinduced increases in Vascular smooth muscle cell viability, caused G1 phase cell cycle arrest and decreased PCNA expression. PMID: 28713961
7. Although lipopolysaccharide (LPS) can trigger inflammation in atherosclerosis, how LPS promotes atherogenesis through acting on macrophages is not very clear. Here, we study the role of adipophilin in LPS-induced inflammation. LPS can promote the expression of adipophilin through the ERK1/2-PPARgamma pathway. PMID: 29099637
8. Cardiac PLIN2 plays an important pathophysiological role in the development of dynamic steatosis and that the latter was prevented by upregulation of intracellular lipases, including Hormone-sensitive Lipase. PMID: 28851734
9. Plin2 liver-specific ablation alleviates diet-induced hepatic steatosis and inflammation via a PEMT-mediated mechanism. PMID: 26968211
10. The relationship between M1-/M2-macrophage polarization and Adp-rich hepatocyte-consisting pseudolobules (PLs) was investigated in thioacetamide (TAA)-induced rat cirrhosis. PMID: 27453055
11. results identify PLIN2 as a determinant of global changes in the hepatic lipidome and suggest the hypothesis that these actions contribute to SREBP-regulated de novo lipogenesis involved in non-alcoholic fatty liver disease. PMID: 27679530
12. Taken together, these findings demonstrate that artesunate inhibits adipogenesis in 3T3-L1 preadipoytes through the reduced expression and/or phosphorylation levels of C/EBP-alpha, PPAR-gamma, FAS, perilipin A, and STAT-3. PMID: 27109481
13. phosphorylation of PLIN2 is dependent on AMPK and occurs after the interaction of PLIN2 with the chaperone-mediated autophagy chaperone HSPA8/Hsc70. PMID: 26902588
14. demonstrate a mutually beneficial relationship between PLIN2 deficiency and elevated apoA-I/HDL-C in preventing atherosclerosis development PMID: 26487692
15. our findings highlight the relationship between protein stability and a previously unnoticed function of Plin2 during lipolysis in adipocytes. PMID: 26876687
16. PLIN2 involves lipid modulation of GSK3 activity, GSK3 substrate expression, and cell growth/survival. PMID: 26598603
17. Plin2 modulates rapid effects of diet on fecal lipid levels, enterocyte CLD contents, and fuel utilization properties of mice that correlate with structural and functional differences in their gut microbial communities PMID: 26147095
18. Postprandial triglyceride rich lipoproteins may be involved in atherosclerotic plaque formation through the regulation of perilipin-2 and perilipin-3 proteins in macrophages. PMID: 25595097
19. flavonoids from Coreopsis tinctoria extracts can reduce blood lipid without liver function damage by down-regulating ADRP. PMID: 25512113
20. The structure and function of specific domains responsible for Plin2-lipid interactions were identified. PMID: 25338003
21. Plin2 has a critical pathogenic role in experimental alcoholic liver disease PMID: 24831094
22. PLIN2-mediated lipid accumulation and utilization by the liver is important for efficient liver regeneration in response to partial hepatectomy and toxic liver injury. PMID: 23928401
23. Together, our findings suggest that WAY, an FXR agonist, attenuates liver steatosis through multiple mechanisms critically involved in the development of hepatosteatosis. PMID: 24875360
24. Collectively these data suggest that whereas perilipin 1 potently suppresses basal lipolysis in adipocytes, perilipins 2 and 3 facilitate higher rates of basal lipolysis PMID: 24927580
25. metformin prevents hepatic steatosis by regulating the expression of ADRP PMID: 24253218
26. Results suggest that Plin2 inhibits glucose uptake by interacting with, and regulating cellular targeting of SNAP23 to lipid droplets. PMID: 24040030
27. Data suggest that both Sertoli cells and germ cells (spermatids), which produce neutral lipids and store them in lipid droplets, express Plin2; expression in Plin2 is up-regulated as spermatogenesis progresses. PMID: 23962454
28. Our study provides the first evidence that Plin2 contributes to HFD-induced obesity by modulating food intake, and that its absence prevents obesity-associated adipose tissue inflammatory foci and liver steatosis. PMID: 23402988
29. Data indicate that PLIN2 and PLIN3 may participate in acute lipid droplet formation in mammalian testes. PMID: 23056214
30. Data suggest that perilipin 2 is essential for lipid storage in skeletal muscle and functions by enhancing partitioning of excess fatty acids toward triglyceride storage in lipid droplets, thereby blunting lipotoxicity-associated insulin resistance. PMID: 22807032
31. Plin2 interacts directly with lipids on the surface of lipid droplets and influences levels of key enzymes and lipids involved in maintaining lipid droplet structure and function. PMID: 22744009
32. Cideb and perilipin 2 play opposing roles in controlling VLDL lipidation and hepatic lipid homeostasis PMID: 22661308
33. Prolactin and epidermal growth factor stimulate adipophilin synthesis in HC11 mouse mammary epithelial cells via the PI3-kinase/Akt/mTOR pathway. PMID: 22426621
34. Data indicate that perilipin 2 deficiency does not increase cholesterol-induced toxicity in macrophages, and thus supports the safety of targeting PLIN2 to prevent foam cell formation and atherosclerosis. PMID: 22427949
35. Adipophilin regulates maturation of cytoplasmic lipid droplets and alveolae in differentiating mammary glands PMID: 21878492
36. interactions between the four-helix bundle of ADPH and membrane phospholipids may be an initial step in milk lipid secretion. PMID: 21383012
37. Data suggest that glucagon has a role in the reorganization of endoplasmic reticulum membranes to generate ADRP-associated lipid-poor particles in hepatic cells, which is related to LD formation during lipid storage. PMID: 20529882
38. Data suggest that adipophilin is involved in atherosclerotic progression. PMID: 20710016
39. Perilipin-2 is a lipid droplet protein in oocytes and its induction in the cumulus-oocyte complexes concurrent with dynamic reorganisation of lipid droplets suggests marked changes in lipid utilisation during oocyte maturation. PMID: 20883652
40. a nonredundant role for ADFP in determining the size and distribution of hepatic lipid droplets PMID: 20424269
41. ADFP is important in regulation of lipid metabolism and insulin secretion in beta-cells PMID: 20484013
42. adipophilin protein expression in muscle is involved in maintaining insulin sensitivity. PMID: 20030713
43. ADRP stimulates lipid accumulation and lipid droplet formation in murine fibroblasts PMID: 12217895
44. a putative alpha-helical region between amino acids 189 and 205 is implicated in both lipid storage droplet (LSD) targeting and regulation of LSD formation PMID: 12562852
45. targeting of the lipid droplet-binding adipocyte differentiation-related protein. PMID: 12591929
46. result indicates that ADRP has two independent domains related to its localization and lipid droplet biogenesis; the unique property found in the present study may be related to physiological function of ADRP [ADRP] PMID: 12804567
47. Diabetic kidneys specifically expressed several genes normally found in adipocytes, including adipocyte differentiation-regulated protein (ADRP) PMID: 15075187
48. GDP-bound ARF1 induces dissociation of ADRP from the Lipid droplet surface;. PMID: 15336557
49. the non-lipid droplet pools of S3-12, adipophilin, and TIP47 constitute a ready reservoir of coat proteins to permit rapid packaging of newly synthesized triacylglycerol and to maximize energy storage during nutrient excess PMID: 15731108
50. proteolytic degradation of ADRP mediated through the ubiquitin/proteasome pathway appears to be a major mode for the post-translational regulation of ADRP PMID: 16115879

Show More

Hide All

KEGG: mmu:11520

STRING: 10090.ENSMUSP00000000466

UniGene: Mm.381