Recombinant Mouse Peroxisome proliferator-activated receptor delta (Ppard)

1. The results confirmed that silencing miR29a induced a decrease in glucose transport and affected lipid metabolism in PAtreated C2C12 cells, and therefore may be involved in insulin resistance by targeting PPARdelta in skeletal muscle. PMID: 29693165
2. Deletion of intestinal PPARdelta protects against diet-induced obesity, insulin resistance and dyslipidemia. PMID: 28404991
3. Data suggest that interaction of Ppard with Tcptp45 blunts insulin resistance and leads to retention of Tcptp45 in nucleus of hepatocytes, myotubes, and adipocytes; alteration of such interactions may be involved in insulin resistance observed in obesity. (Ppard = peroxisome proliferator activator receptor delta; Tcptp45 = protein tyrosine phosphatase non-receptor type 2 [Ptpn2], 45kDa alternative splicing variant) PMID: 29233935
4. CRY1/2 seem to repress a distinct subset of PPAR delta target genes in muscle compared to the co-repressor NCOR1. In vivo, genetic disruption of Cry1 and Cry2 enhances sprint exercise performance in mice. PMID: 28683290
5. Exhaustion of systemic glucose limits endurance exercise. PPARdelta regulates substrate utilization without mitochondrial biogenesis. PPARdelta represses glycolytic genes in muscle to slow glucose consumption. Glucose sparing by PPARdelta dramatically extends running time. PMID: 28467934
6. The HFHC diet polarized the liver toward a proinflammatory M1 state, which was reversed by GW1516 intervention. Thus, PPARdelta agonist treatment inhibits the progression of preestablished hepatic steatosis. PMID: 24864274
7. data suggested that PPARbeta-regulated PDK1/Akt and E2f signaling that controls metabolism and proliferation is involved in the normal progression of liver regeneration PMID: 23823620
8. Since the R6/2 mice represent a 'truncated' huntingtin (Htt) mouse model of Huntington's disease (HD), we tested the efficacy of bezafibrate in a 'full-length' Htt mouse model, the BACHD mice. Bezafibrate treatment restored the impaired PPARg, PPARd, PGC-1a signaling pathway, enhanced mitochondrial biogenesis and improved antioxidant defense in the striatum of BACHD mice PMID: 27008868
9. we demonstrated that by modulating mitochondrial energy metabolism through Mfn2 and mitochondrial Ca2+, PPAR-b took an important role in neuronal differentiation induced by flavonoid compound 4a PMID: 27315062
10. PPAR-delta activation prevents in-stent restenosis and stent thrombosis. PMID: 27283742
11. The results demonstrate that PPARdelta-mediated inhibition of ER stress contributes to the vascular benefits of exercise. PMID: 27856609
12. this study shows that PPARbeta/delta is an important regulator of mast cell phenotype PMID: 27935639
13. findings identify LPCAT3 as a direct PPARdelta target gene and suggest a novel function of PPARdelta in regulation of phospholipid metabolism through LPCAT3. PMID: 27913621
14. Taken together, we provide crucial evidence that miR-132 plays a key role in regulating osteogenic differentiation through Sirt1 in a PPARbeta/delta-dependent manner, indicating that miR-132 and Sirt1-PPARbeta/delta may act as potential therapeutic targets for T2DM-induced osteoporosis. PMID: 27422605
15. results from the present study demonstrate a novel regulatory role of PPARbeta/delta in modulating CYP2B10 that may contribute to the etiology of alcoholic liver disease. PMID: 27765815
16. PPARbeta/PPARgamma activation restored the LPS-induced endothelial dysfunction by upregulation of UCP2, with the subsequent alleviation of ER stress and NADPH oxidase activity, thus reducing intracellular reactive oxygen species production and increasing nitric oxide bioavailability. PMID: 27179975
17. Leucine significantly increased PPARbeta/delta expression with enhanced glucose transporter 4 (GLUT4) content and glucose uptake in myotubes. PMID: 27345255
18. Although further studies are required to establish the role of PPARbeta/delta in lung tissue, this study indicates the possibility that PPARbeta/delta agonists may be useful as new therapeutic agents for pulmonary emphysema PMID: 27150147
19. This study reports that high sodium intake remarkably increased natriuresis in wild-type mice, but this effect was blunted in adipose-specific PPARdelta knockout mice and diabetic mice. PMID: 27053360
20. PPAR-delta agonist reduces fatty acid-induced inflammation and steatosis by suppressing inflammasome activation. PMID: 26668503
21. These results suggest that hippocampal PPARdelta upregulation represses stress-induced depressive behaviors, accompanied by enhancement of neurogenesis. PMID: 26362775
22. Data suggest enhancement of hepatocyte mitochondrial biogenesis and beta-oxidation by all-trans-retinoic acid requires peroxisome proliferator activated receptor delta; retinoic acid receptor alpha/beta do not appear to be involved in this response. PMID: 26921399
23. BAIBA attenuates insulin resistance, suppresses inflammation and induces fatty acid oxidation via the AMPK-PPARdelta pathway in skeletal muscle PMID: 26105792
24. Collectively, these results suggest that PPARbeta/delta enhances myoblast differentiation through activation of promyogenic signaling pathways. PMID: 26768366
25. Expression of dominant-negative PPAR-delta in the CNS was sufficient to induce motor dysfunction, neurodegeneration, mitochondrial abnormalities and transcriptional alterations that recapitulated Huntington disease-like phenotypes. PMID: 26642438
26. These results suggest that PPARdelta protects against the neuronal effects of fatty acids, which differentially affect neurochemical systems involved in ingestive behavior. PMID: 26332891
27. Study suggests that neuronal PPARg or PPARd does not counteract MPTP-induced toxicity PMID: 26028469
28. Training increases energy availability by promoting catabolism of proteins, and gluconeogenesis, whereas GW501516 enhances specific consumption of fatty acids and reducing glucose utilization. PMID: 25943561
29. results reveal for the first time that PPARD regulates spermatogenesis by modulating the function of Sertoli cells during early testis development. PMID: 26242735
30. Data show that peroxisome-proliferator-activated receptor beta/delta (PPARbeta/delta) activation restored the lipid-induced endothelial dysfunction by up-regulation of carnitine palmitoyltransferase)-1 (CPT-1). PMID: 26253087
31. Data show that peroxisome proliferator activator receptor delta (PPARdelta/beta) directly regulates CD300a protein in macrophages. PMID: 24958459
32. Absence of PPARbeta/delta leads to loss of satellite cells, impaired skeletal muscle regeneration, and postnatal myogenesis. PMID: 25921579
33. Endothelial, but not smooth muscle, PPARgamma/PPARdelta regulates vascular permeability and anaphylaxis. PMID: 25556996
34. The data indicate a novel detrimental age-dependent role of PPAR beta/delta in Alzheimer disease by increasing pro-BDNF and decreasing BDNF/TrkB survival pathways. PMID: 24621497
35. PPAR-gamma and PPAR-delta upregulation of SIRT1 modulates the status of HMGB1 acetylation. PMID: 25275593
36. appears to regulate myostatin and PPARgamma expression in muscle and bone PMID: 25279796
37. Data (including data from transgenic mice) suggest that Ppard activation (here using GW501516) elicits dramatic changes in metabolic activities in placenta including glycolysis and biosynthesis of phosphatidylethanolamine and syncytin-A. PMID: 24920036
38. Peroxisome proliferator-activated receptor delta promotes the progression of posttraumatic osteoarthritis in a mouse model. PMID: 25331977
39. Data show that peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) promotes HRAS-induced senescence to inhibit tumorigenesis by potentiating p-ERK1/2 and repressing p-AKT signaling. PMID: 24213576
40. No differences in kidney histology were observed in any of the experimental groups. Kefir, koumiss, yogurt and the commercial probiotic preparation increased PPARalpha and PPAR-beta/delta expressions. PMID: 24205877
41. new role for ER stress and UPR that attenuates H-RAS-induced senescence and suggest that PPARbeta/delta can repress this oncogene-induced ER stress to promote senescence in accordance with its role as a tumor modifier that suppresses carcinogenesis PMID: 24898257
42. PPARbeta/delta-null mice developed fewer and smaller skin tumours, and a PPARbeta/delta antagonist prevented UV-dependent Src stimulation. PMID: 24203162
43. PPAR delta Mediates the Effects of Desnutrin-Catalyzed Lipolysis on Insulin Secretion PMID: 24268737
44. PPARdelta promotes colonic inflammation and colitis-associated tumor growth via the COX-2-derived PGE2 signaling axis that mediates cross-talk between tumor epithelial cells and macrophages. PMID: 24763687
45. Serotonin 2B receptor (5-HT2B R) signals through prostacyclin and PPAR-ss/delta in osteoblasts. PMID: 24069449
46. PPAR-d upregulation greatly enhances susceptibility to colonic tumorigenesis. PMID: 24681603
47. Pleiotropic effects of peroxisome proliferator-activated receptor gamma and delta in vascular diseases. [review] PMID: 24107399
48. All-trans retinoic acid levels, RAR-mediated signaling and signaling involved in PPARdelta pathways are mainly increased in allergen-induced dermatitis and may contribute to the development and/or maintenance of allergic skin diseases. PMID: 23977003
49. Increasing delta-9 desaturase activity of muscle increases metabolic function, exercise capacity, and lipid oxidation which increases PPARD expression and activity. PMID: 23918045
50. These data suggest that M2 macrophages represent a unique niche for long-term intracellular bacterial survival and link the PPARdelta-regulated metabolic state of the host cell to persistent bacterial infection. PMID: 23954156

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KEGG: mmu:19015

STRING: 10090.ENSMUSP00000002320

UniGene: Mm.328914