Recombinant Mouse Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (Ppargc1a)

1. The expression level of myocardial PGC-1alpha in MI mice with cardiac rupture after MI was significantly higher than that in the mice without cardiac rupture, and the ratio of myocardial NT-PGC-1alpha/PGC-1alpha was low. PMID: 30275441
2. These findings show that melatonin attenuates the development of diabetes-induced cardiac dysfunction by preventing mitochondrial fission through SIRT1-PGC1alpha pathway, which negatively regulates the expression of Drp1 directly. PMID: 29575122
3. Nicotinamide riboside (NR) can protect against ethanol induced liver injuries via replenishing NAD(+), reducing oxidative stress, and activating SirT1-PGC-1a-mitochondrial biosynthesis. Our data indicate that SirT1 plays an important role in the protection of NR against lipid accumulation and mitochondrial dysfunctions induced by ethanol PMID: 29679894
4. Findings demonstrated that one bout of both uphill and downhill exercise trainings as well as 8 weeks of training could increase the expression of PGC-1alpha and FNDC5 genes in the muscle tissues and the UCP1 gene in the subcutaneous adipose tissue. PMID: 30218749
5. Studied the involvement of peroxisome proliferative activated receptor gamma coactivator 1 alpha (PGC-1a) in beta-cell dysfunction and impairment of its ability to secrete insulin. PMID: 28259539
6. At least in the subcutaneous fat of humans and mice, the levels of PGC-1a decrease during obesity, while its physical association with A20 increases. PMID: 29678181
7. During catecholamine-stimulated lipolysis, Perilipin 5 is phosphorylated by protein kinase A and forms transcriptional complexes with PGC-1alpha and SIRT1 in the nucleus. Perilipin 5 promotes PGC-1alpha co-activator function by disinhibiting SIRT1 deacetylase activity. PMID: 27554864
8. the coordinated expression of FNDC5 and PGC-1alpha may contribute to the increased levels of plasma irisin after exercise. PMID: 29415899
9. Endogenous PGC1alpha expression exhibited protective effects against oxidative stress, glomerulosclerosis and tubulointerstitial fibrosis in experimental diabetic kidney disease. PMID: 29344670
10. Resistin inhibited the activation of CREB, resulting in suppression of PGC-1alpha. Importantly, overexpressing PGC-1alpha can rescue the inhibitory effects of resistin on fatty acid beta oxidation. PMID: 29730652
11. A cap-binding protein 80 (CBP80)-binding motif (CBM) in the C terminus of PGC-1alpha is critical for the association of PGC-1alpha with CBP80 at the 5' cap of target transcripts. PMID: 29654059
12. findings support the hypothesis that maternal diabetes-induced ER stress increases CHOP expression which represses PGC-1alpha through suppressing the C/EBPbeta transcriptional activity, subsequently induces mitochondrial dysfunction and ultimately results in NTDs PMID: 28482072
13. PGC-1alpha does not seem to regulate the activity of hepatic unfolded protein response in response to exercise training, but to influence the capacity of the liver to induce UPR in a pathway specific manner. PMID: 28801170
14. AMPK-PGC-1a control of mitochondrial reactive oxygen species regulates Warburg metabolism. PMID: 28978464
15. At 11 weeks, the MCK-PGC-1alpha animals had 50% greater glucose tolerance integrated area under the curve compared with WT. PMID: 28639297
16. In the absence of serum, hypoxia and high glucose conditions, PGC-1alpha can regulate the expression of Bcl-2 and promote the survival of MSCs via PGC-1alpha/ERRalpha interaction. PMID: 28711948
17. PGC-1alpha is involved in resveratrol-induced microglia M2 polarization. PGC-1alpha regulates microglia polarization through NF-kappaB, STAT6 and STAT3 pathways PMID: 28268115
18. Study provides evidence that PGC-1a is a mediator of ischemic preconditioning that is downregulated in the steatotic liver, blunting the induction of protective antioxidant enzymes. PMID: 28269997
19. that oxidatively-mediated reductions in parkin solubility and function in a mouse model of age-related sporadic PD coincides with increased PARIS levels and reduced PGC-1alpha signaling PMID: 27185595
20. in the skeletal muscle, PGC-1alpha activates ALT2 gene expression, and alanine production may play roles in adaptation to fasting PMID: 29315328
21. PPAR-beta increases PGC-1alpha content via a reduction in protein degradation. PMID: 28467933
22. Muscle-specific PGC-1alpha transgenic mice have lower satellite cell number. SCs from these mice have a higher propensity for activation and proliferation. PMID: 27908291
23. Full length-PGC-1alpha-deficient mice can be regarded not only as morphological but behavioral models of mitochondrial encephalopathies PMID: 27424777
24. The Genomic Context and Corecruitment of SP1 Affect ERRalpha Coactivation by PGC-1alpha in Muscle Cells PMID: 27182621
25. These findings indicate that IGF-II reduces PGC-1alpha expression in skeletal muscle cells through a mechanism involving PI3K-Akt-FoxO1 but not p38 MAPK or Erk1/2 MAPK pathways. PMID: 28374141
26. Findings demonstrate that PGC-1alpha protects against podocyte depletion and phenotypic changes possibly by maintaining normal mitochondrial function. PMID: 26943584
27. The involvement of mTOR-PGC-1alpha pathway in the connection between FTO and muscle differentiation is displayed. PMID: 28333151
28. findings indicate that exercise intensity affected autophagy markers differently in skeletal muscle and suggest that PGC-1alpha regulates both acute and exercise training-induced autophagy in skeletal muscle potentially in a PGC-1alpha isoform specific manner PMID: 29049322
29. EET-mediated increase in HO-1 levels require PGC-1alpha expression PMID: 27418542
30. This change in the cellular location of p53 alleviates the abrogation of PGC-1a repression caused by nuclear p53, which may further increases PGC-1a expression PMID: 27497229
31. Peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) exerts beneficial effects on muscle inflammation that might contribute to the therapeutic effects of elevated muscle PGC-1alpha in different models of muscle wasting. PMID: 27833743
32. Adult conditional PGC-1alpha knock-out mice show a significant loss of dopaminergic neurons that is accompanied by a reduction of dopamine in the striatum. Study identifies also two brain-enriched isoforms of PGC-1alpha: PGC-1alpha1L (160 kDa) and PGC-1alpha1S (100 kDa). PMID: 27622213
33. The study propose that gluconeogenesis driven by NTPGC- 1a, along with PGC-1a, contributes to the elevated blood glucose level in response to fasting. PMID: 27798359
34. Metagenomic analysis revealed direct correlation between PPARGC1A, SNAI1, and metastatic lung disease. PMID: 28803067
35. Destabilization of PGC1a is attributable to decreased p38 MAPK activation via diminished CaMKII signaling. Thus, we elucidate a pathway downstream of Ca(2+)-mediated CaMKII activation that is dysfunctional in C3KO(Capn3 knock-out mice ) mice, leading to reduced transcription of genes involved in muscle adaptation PMID: 27005420
36. lncBATE10 can decoy Celf1 from Pgc1alpha, thereby protecting Pgc1alpha mRNA from repression by Celf1 PMID: 28763438
37. this study shows that PGC-1alpha overexpression improves metabolism in virus-specific CD8+ T cells generated during acute infection PMID: 27496729
38. this study reports that tumor-infiltrating T cells show a progressive loss of PGC1alpha, and that overexpression of PGC1alpha results in superior intratumoral T cell functions PMID: 27496732
39. This is the first study to dissect the mechanism by which the antiadipogenic and anti-inflammatory lipid, Epoxyeicosatrienoic acid, induces the PGC-1alpha signaling cascade and reprograms the adipocyte phenotype by regulating mitochondrial function and HO-1 expression. PMID: 27224420
40. The accelerated conversion of T4 to T3 within myocytes mediates part of the PGC-1a induction by treadmill exercise and its downstream effects on mitochondrial function PMID: 27302464
41. Study demonstrates a novel role for peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) in nucleus accumbens (NAc) in cocaine action. PGC-1alpha is enhanced in NAc dopamine D1-medium spiny neurons, specifically after cocaine exposure. These data are consistent with increased active methylation and early growth response 3 binding at the PGC-1alpha promoter. PMID: 27939396
42. These data reveal a new role for muscle PGC-1alpha in regulating the physiological adaptation to long-term LCHF diet administration. PMID: 28223292
43. These results demonstrate a central role of skeletal muscle PGC-1alpha in the transcriptional regulation of systemic ketolytic capacity. PMID: 26849960
44. PGC-1alpha expression in cardiomyocytes is regulated by interleukin-6 and is down-regulated in animals fed a high-fat diet. PMID: 27253588
45. the data strengthen our previous findings that NT-PGC-1alpha regulates mitochondrial genes involved in thermogenesis and oxidative metabolism in brown and white adipocytes and further suggest that NT-PGC-1alpha regulates a broad spectrum of genes to meet cellular needs for adaptive thermogenesis. PMID: 27454177
46. role of PGC-1alpha in renal mitochondrial biogenesis indicates that activation of PGC-1alpha in the context of renal disorders could be a valid therapeutic strategy to ameliorate renal mitochondrial dysfunction PMID: 27463191
47. Results delineate a cross talk between a central pathway controlling metabolic regulation and cell adhesion, and identify PGC-1alpha as a molecular link between these two major cellular networks. PMID: 27984584
48. Data suggest NT-Pgc-1alpha (alternative splicing isoform of nuclear protein Pgc-1alpha) is located in mitochondrial matrix in brown adipocytes, specifically enriched at D-loop region of mitochondrial DNA at promoter region of Lrpprc (leucine-rich PPR-motif containing protein); expression of NT-Pgc-1alpha (rather than Pgc-1alpha) in brown adipocytes appears to induce expression of electron transport chain complex proteins. PMID: 28473468
49. Data suggest that PGC-1alpha and -1beta expression are not required for training-induced exercise performance, highlighting the contribution of PGC-1-independent mechanisms. PMID: 27780821
50. Data show that resveratrol reduced mitochondrial reactive oxygen species (mROS) generation by promoting Sirt3 enrichment within the mitochondria and subsequent upregulation of FoxO3a-mediated mitochondria gene expression of PGC-1alpha and SOD2. PMID: 28286268

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KEGG: mmu:19017

STRING: 10090.ENSMUSP00000117040

UniGene: Mm.259072