Recombinant Mouse Plasma protease C1 inhibitor (Serping1)

Code CSB-YP021086MO
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Source Yeast
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Code CSB-EP021086MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP021086MO
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Source Baculovirus
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Code CSB-MP021086MO
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Serping1
Uniprot No.
Alternative Names
Serping1; C1nh; Plasma protease C1 inhibitor; C1 Inh; C1Inh; C1 esterase inhibitor; C1-inhibiting factor; Serpin G1
Species
Mus musculus (Mouse)
Expression Region
23-504
Target Protein Sequence
DPEATSHS TQDPLEAQAK SRESFPERDD SWSPPEPTVL PSTWPTTSVA ITITNDTMGK VANESFSQHS QPAAQLPTDS PGQPPLNSSS QPSTASDLPT QATTEPFCPE PLAQCSDSDR DSSEAKLSEA LTDFSVKLYH AFSATKMAKT NMAFSPFSIA SLLTQVLLGA GDSTKSNLES ILSYPKDFAC VHQALKGFSS KGVTSVSQIF HSPDLAIRDT YVNASQSLYG SSPRVLGPDS AANLELINTW VAENTNHKIR KLLDSLPSDT CLVLLNAVYL SAKWKITFEP KKMMAPFFYK NSMIKVPMMS SVKYPVAQFD DHTLKAKVGQ LQLSHNLSFV IVVPVFPKHQ LKDVEKALNP TVFKAIMKKL ELSKFLPTYL TMPHIKVKSS QDMLSVMEKL EFFDFTYDLN LCGLTEDPDL QVSAMKHETV LELTESGVEA AAASAISFGR SLPIFEVQRP FLFLLWDQQH RFPVFMGRVY DPRG
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. May inhibit chymotrypsin and kallikrein.
Gene References into Functions
  1. C1INH prevented myocardial ischemia reperfusion injury in mice. PMID: 22705194
  2. Transgenic mice have been generated that express human C1 inhibitor mRNA and protein under the control of the human promoter and regulatory elements; C1nh production is demonstrated in mouse brain, spleen, liver, heart, kidney, and lung. PMID: 12421980
  3. In vivo, C1 inhibitor (C1INH) reduces the number of viable bacteria in the blood and peritoneal fluid and accelerates killing of bacteria by blood neutrophils and peritoneal macrophages. PMID: 17785834
  4. C1-inhibitor limits neointimal plaque formation and inflammation. This may involve blockade of complement activation, inhibition of leukocyte recruitment, and reduced triglyceride levels PMID: 18071075
  5. In addition to the protective activities mediated via inhibition of the complement system, these studies indicate that C1INH also plays a direct role in suppression of leukocyte transmigration into reperfused tissue. PMID: 18787060

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Subcellular Location
Secreted.
Protein Families
Serpin family
Database Links
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