Recombinant Mouse Properdin (Cfp)

Code CSB-BP005291MO
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-EP005291MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Cfp
Uniprot No.
Alternative Names
Cfp; Pfc; Properdin; Complement factor P
Species
Mus musculus (Mouse)
Expression Region
23-464
Target Protein Sequence
SDPVLCFT QYEESSGRCK GLLGRDIRVE DCCLNAAYAF QEHDGGLCQA CRSPQWSAWS LWGPCSVTCS EGSQLRHRRC VGRGGQCSEN VAPGTLEWQL QACEDQPCCP EMGGWSEWGP WGPCSVTCSK GTQIRQRVCD NPAPKCGGHC PGEAQQSQAC DTQKTCPTHG AWASWGPWSP CSGSCLGGAQ EPKETRSRSC SAPAPSHQPP GKPCSGPAYE HKACSGLPPC PVAGGWGPWS PLSPCSVTCG LGQTLEQRTC DHPAPRHGGP FCAGDATRNQ MCNKAVPCPV NGEWEAWGKW SDCSRLRMSI NCEGTPGQQS RSRSCGGRKF NGKPCAGKLQ DIRHCYNIHN CIMKGSWSQW STWSLCTPPC SPNATRVRQR LCTPLLPKYP PTVSMVEGQG EKNVTFWGTP RPLCEALQGQ KLVVEEKRSC LHVPVCKDPE EKKP
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b).
Gene References into Functions
  1. The results show that Properdin plays a key role in allergen-induced airway inflammation and represents a potential therapeutic target for human asthma. PMID: 26116506
  2. Authors conclude that properdin controls the strength of immune responses by affecting humoral as well as cellular phenotypes during acute bacterial infection and ensuing inflammation. PMID: 24728387
  3. Properdin deficiency exacerbated renal injury in mice lacking complement factor H. PMID: 23184055
  4. deficiency of properdin in mice with factor H mutation exacerbates C3 glomerulonephritis PMID: 23204401
  5. Murine antigonococcal antiserum required functional properdin to kill C4BP-binding strains, but not C4BP-nonbinding strains. PMID: 22368277
  6. properdin may be added to the list of complement proteins which influence lipid metabolism, energy storage and insulin resistance, and further support the hypothesis of a dual role of complement in adipose tissue PMID: 22387270
  7. At the initial phase of local, zymosan-induced inflammation, properdin-deficient and wild-type mice showed bone erosion, proteoglycan loss and cell infiltration. PMID: 20226532
  8. Properdin localizes to mast cells, has the ability to directly associate with Escherichia coli DH5alpha, and plays a significant role in the outcome of polymicrobial sepsis. PMID: 18292556
  9. properdin deficiency attenuates zymosan-induced shock and exacerbates LPS-induced shock. PMID: 18453618

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Subcellular Location
Secreted.
Database Links
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