Recombinant Mouse Prostaglandin-H2 D-isomerase (Ptgds)

1. These observations suggest that tumor cell-derived inflammatory cytokines increase L-PGDS expression and subsequent PGD2 production in the tumor endothelial cells (ECs). This PGD2 acts as a negative regulator of the tumorigenic changes in tumor ECs. PMID: 29124765
2. Exposure of macrophages to cyclooxygenase (COX-2) inhibitors RhoA and LA-4 cells to antagonists of prostaglandin E2 (PGE2) receptor , PGD2 receptors or the hepatocyte growth factor (HGF) receptor c-Met (PHA-665752), reversed EMT inhibition by the conditioned medium PMID: 26875548
3. Ptgds is targeted and repressed by the CUL4B/PRC2 complex. PMID: 26025376
4. Thermodynamic and nuclear magnetic resonance analyses demonstrated that L-PGDS binds to nicotinamide coenzymes, including NADPH, NADP(+), and NADH. PMID: 26518650
5. Prostaglandin D2 synthase is a novel MR target gene in adipocytes. PMID: 25966493
6. When prostaglandin D2 synthase is upregulated it participates in the regulation of peripheral nervous system myelination. PMID: 25362470
7. expression of L-PGDS in mouse lungs decreased neutrophilic infiltration, ameliorating lung inflammation in mice. PMID: 24029383
8. Silencing of PTGDS also alleviated H-rev107-mediated suppression of cell migration and invasion PMID: 23687991
9. In this report, we show for the first time that alteration of the PTGDS-governed PGD2 pathway disturbs testicular migration in mice. PMID: 23076868
10. The levels of lipocalin-type prostaglandin D2 synthase, and its product PGD2 each varied significantly among background strains of mice after wounding, and the highest Ptgds and PGD2 levels were associated with the lowest amount of regeneration. PMID: 23190891
11. The lipocalin-type prostaglandin D2 KO mice show early elevations in HPA activity with no age-related changes relative to the C57BL/6 mice. PMID: 23151358
12. Results suggest that L-PGDS plays an important role in the regulation of glucose utilization in vivo. PMID: 22923471
13. Findings demonstrate that the backbone conformation of the bottom region of mouse lipocalin-type prostaglandin D synthase is still maintained in the intermediate state. PMID: 22210903
14. Negative regulation of the adipogenesis program by the enhanced expression of L-PGDS through a cellular mechanism involving the interference of the PPARgamma signaling pathway without the contribution of endogenous pro-adipogenic prostanoids. PMID: 22100987
15. PGD2 is produced in articular tissue during the development of collagen-induced arthritis and plays an antiinflammatory role, acting through the DP1 receptor. PMID: 21898357
16. results suggest the importance of selenium in the shunting of AA metabolism toward the production of PGD(2) metabolites, which may have clinical implications PMID: 21669866
17. These results suggest that the stably reduced expression levels of L-PGDS regulates positively adipogenesis program in a cellular mechanism independent of pro-adipogenic action of PGJ(2) series. PMID: 21726533
18. Study suggests that PGD(2) derived from L-PGDS-expressing cells plays proinflammatory roles in colitis. PMID: 21163901
19. L-PGDS may fine-tune the retinoic acid signalling in melanocytes. PMID: 20403807
20. PGD synthase is elevated in the urine and kidneys of mice during anti-glomerular basement membrane disease, as well as in mice with spontaneously arising lupus nephritis. PMID: 20065116
21. The expression of H-PGDS in human dendritic cells (DCs) and the regulatory mechanisms by which DCs produce prostaglandin D2, is demonstrated. PMID: 20008150
22. Expression of prostaglandin D synthase in ovarian cancer. PMID: 11798075
23. The protein is present throughout the epididymis, except in the initial segment; a major protein in caudal fluid;an N-glycosylated, highly polymorphic protein; and conserved during evolution. PMID: 11804971
24. enzyme is characterized, folded and unfolded. PMID: 12441340
25. Estradiol differentially regulates its transcript levels in the rodent brain: evidence from high-density oligonucleotide arrays and in situ hybridization PMID: 12518068
26. PGD synthase in brain microglia peaked at postnatal day (PND) 10, decreased gradually thereafter, and reached a plateau at PND 20. Target molecules of PGD2, i.e., DP receptor and CRTH2 receptor, showed developmental profiles similar to PGD synthase. PMID: 12673832
27. Crystallization and preliminary X-ray analysis of lipocalin-type prostaglandin D synthase. PMID: 12761195
28. prostaglandin D synthase in the preoptic area of female mice has a role in arousal and sex behavior PMID: 14638944
29. Hematopoietic prostaglandin D synthase is produced by microglia until 72 h after reperfusion, but at 7 days after reperfusion, it is also produced by migrating bone marrow/blood-derived macrophages in the ischemic brain tissue. PMID: 17241746
30. Liver X receptor-mediates up-regulation of L-PGDS through activation of SREBP-1c is a novel pathway to enhance adipocyte differentiation PMID: 17439953
31. L-PGDS induction was regulated positively by AP-1, but negatively by p53. PMID: 17675519
32. NMR solution structure of L-PGDS: evidence for partial overlapping of catalytic pocket and retinoic acid-binding pocket within the central cavity. PMID: 17715133
33. the thermal unfolding monitored by CD spectroscopy at 200, 235 and 290 nm revealed that L-PGDS unfolded through the intermediate state, where its main chain retained the characteristic beta-sheet structure without side-chain interactions PMID: 18076651
34. 15-PGJ(2) is synthesized during mammalian inflammatory responses PMID: 18077391
35. L-PGDS is an important mediator of muscle and adipose glucose transport which is modulated by glycemic conditions and plays a significant role in the glucose intolerance associated with type 2 diabetes. PMID: 18619553
36. l-pgds deficiency induces obesity and facilitates atherosclerosis, probably through the regulation of inflammatory responses. PMID: 19070593
37. Biochemical, functional, and pharmacological characterization of AT-56, an orally active and selective inhibitor of lipocalin-type prostaglandin D synthase. PMID: 19131342
38. Our findings suggest that L-PGDS is beneficial for protecting the brain against transient and permanent cerebral ischemia. PMID: 19254753
39. Overexpression of prostaglandin D synthase augments inflammation followed by muscle injury in muscular dystrophy. PMID: 19359520
40. This cardioprotective effect of dexamethasone was markedly reduced in L-PGDS-deficient mice PMID: 19451694
41. L-PGDS expression is induced in the myocardium under hypoxemia, which may reflect the adaptation to the hemodynamic stress. PMID: 19470375
42. analysis of the structural basis of the catalytic mechanism operating in open-closed conformers of lipocalin type prostaglandin D synthase PMID: 19546224
43. First report of insulin resistance, glucose intolerance, and early atherosclerosis associated with L-PGDS knockout. PMID: 15970590

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KEGG: mmu:19215

STRING: 10090.ENSMUSP00000015234

UniGene: Mm.1008