Recombinant Mouse Protein CYR61(Cyr61)

Code CSB-YP006463MO
Product Type Recombinant Protein
Size US$2474
Uniprot No. P18406
Relevance Promotes cell proliferation, chotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix rodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 . CYR61-mediated gene regulation is dependent on heparin-binding . Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 . Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 .
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias 3CH61CCN family member 1Cysteine-rich angiogenic inducer 61Insulin-like growth factor-binding protein 10 ;IBP-10 ;IGF-binding protein 10 ;IGFBP-10
Species Mus musculus (Mouse)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence TCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVSGQCCEEWVCDEDSIKDSLDDQDDLLGLDASEVELTRNNELIAIGKGSSLKRLPVFGTEPRVLFNPLHAHGQKCIVQTTSWSQCSKSCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTYAGCSSVKKYRPKYCGSCVDGRCCTPLQTRTVKMRFRCEDGEMFSKNVMMIQSCKCNYNCPHPNEASFRLYSLFNDIHKFRD
Research Area Others
Source Yeast
Gene Names Cyr61
Protein Names Recommended name: Protein CYR61 Alternative name(s): 3CH61 CCN family member 1 Cysteine-rich angiogenic inducer 61 Insulin-like growth factor-binding protein 10 Short name= IBP-10 Short name= IGF-binding protein 10 Sh
Expression Region 25-379aa
Tag Info N-terminal 6xHis-tagged
Mol. Weight 41.1kDa
Protein Description Full Length of Mature Protein
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CYR61-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 (By similarity).
Subcellular Location Secreted
Protein Families CCN family
Tissue Specificity Low in kidney, adrenal gland, testes, brain, and ovary, moderate in heart, uterus, and skeletal muscle, highest in lung.
Database Links

KEGG: mmu:16007

STRING: 10090.ENSMUSP00000029846

UniGene: Mm.1231

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