Code | CSB-EP006463MO |
MSDS | |
Size | US$306 |
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This recombinant Mouse Cyr61 protein is an E.coli expressed protein (Full Length of Mature Protein) with N-terminal 10xHis tag and its purity is 90%+ determined by SDS-PAGE. With the appropriate cDNA and PCR methods, Cyr61 expression plasmids can be rapidly produced. which must undergo denaturation and folding cycle, can be recovered with more modest yields. Hence, using small-scale fermentations and laboratory-scale processing equipment, Cyr61 proteins (or subdomains thereof) can usually be produced in sufficient quantities to initiate most studies including detailed structural determinations.which must undergo denaturation and folding cycle, can be recovered with more modest yields. Hence, using small-scale fermentations and laboratory-scale processing equipment, Cyr61 proteins (or subdomains thereof) can usually be produced in sufficient quantities to initiate most studies including detailed structural determinations.
Cyr61, also called Ccn1, is a growth factor-inducible prompt response transcription product that regulates cell proliferation, survival, differentiation, migration, apoptosis, angiogenesis, adhesion, and synthesis of extracellular matrix (ECM) via cell type-specific binding mainly to α6β1, αMβ2, and αVβ3 integrins. It also plays a vital role in the female reproductive system during embryogenesis and tumorigenesis. Cyr61 is upregulated as an angiogenic factor in the cardiovascular system under pathophysiological conditions, revealing a role for Cyr61 in cellular and tissue self-renewal, potentially involving circulating progenitor cells. Studies have found that Cyr61 limits fibrosis in the liver and inhibits hepatocarcinogenesis by blocking EGFR-dependent hepatocyte compensatory proliferation.There are currently no reviews for this product.