Recombinant Mouse Protein Wnt-8a(Wnt8a)

Code CSB-YP734110MO
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Source Yeast
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Code CSB-EP734110MO
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Source E.coli
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Code CSB-EP734110MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP734110MO
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Source Baculovirus
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Code CSB-MP734110MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Wnt8a
Uniprot No. Q64527
Alternative Names Wnt8a; Stra11; Wnt8d; Protein Wnt-8a; Protein Wnt-8d; Stimulated by retinoic acid gene 11 protein
Species Mus musculus (Mouse)
Expression Region 20-354
Target Protein Sequence A SAWSVNNFLI TRPKAYLTYT ASVALGAQIG IEECKFQFAW ERWNCPEHAF QFSTHNRLRA ATRETSFIHA IRSAAIMYAV TKNCSMGDLE NCGCDESQNG KTGGHGWIWG GCSDNVEFGE KISRLFVDSL EKGKDARALV NLHNNRAGRL AVRASTKRTC KCHGISGSCS IQTCWLQLAD FRQMGNYLKA KYDRALKIEM DKRQLRAGNR AEGRWALTEA FLPSTEAELI FLEGSPDYCN RNASLSIQGT EGRECLQNAR SASRREQRSC GRLCTECGLQ VEERRAEAVS SCDCNFQWCC TVKCGQCRRV VSRYYCTRPV GSARPRGRGK DSAW
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning.
Gene References into Functions
  1. Caudal Wnt8a is expressed only early somite stages. It is needed for normal anterior trunk development in the absence of Wnt3a. Wnt8a and Wnt3a cooperate to maintain Fgf8 expression and stop premature Sox2 up-regulation in the axial stem cell niche. PMID: 25809880
  2. Wnt8a expression depends on the presence of Fgf3 indicating a serial regulation between Fgf and Wnt signalling during otic placode induction and specification. PMID: 23041177
  3. demonstrate that both the enlargement of the otic placode and the expansion of the Wnt8a expression domain can be rescued in Spry1/; Spry2/ embryos by reducing the gene dosage of Fgf10 PMID: 21362415
  4. FGF signaling regulates otic placode induction and refinement by controlling both ectodermal target genes and hindbrain Wnt8a. PMID: 20171206
  5. Developmental regulation of this protein is involved in cardiac myogenesis PMID: 12719544
  6. The Wnt8A expression was evaluted in the resultant Tg(CAG-mWnt8A) embryos to identify mWnt8A misexpression. PMID: 16256739

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Subcellular Location Secreted, extracellular space, extracellular matrix. Secreted.
Protein Families Wnt family
Database Links

KEGG: mmu:20890

STRING: 10090.ENSMUSP00000012426

UniGene: Mm.558

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