Recombinant Mouse Ras-related protein Rap-1A (Rap1a)

1. Using an RNA-mediated interference screen, we identified phospholipase Cepsilon 1 (PLCepsilon1) as a crucial regulator of stromal cell-derived factor 1 alpha (SDF-1alpha)-induced Rap1 activation. We have shown that SDF-1alpha-induced activation of Rap1 is transient in comparison with the sustained level following cross-linking of the antigen receptor. PMID: 28213494
2. loss of Rap1 GTPases prevents the formation of axons and leading processes and thereby interferes with radial migration PMID: 26733533
3. neuronal Rap1 critically regulates leptin sensitivity PMID: 27626668
4. the Rap1-cofilin-1 pathway coordinates actin and microtubule organization at the immune synapse. PMID: 28167682
5. Rap1 mediates the effects of increased extracellular tension in multiple ways that are capable of contributing to tumor progression when dysregulated. PMID: 27199371
6. Results from comparative proteomics identified Rap1 as a novel legionella-containing-vacuole host component implicated in intracellular replication of Legionella pneumophila. PMID: 28183814
7. These results suggest that Rap1 activation of ERKs requires PKA phosphorylation and KSR binding. PMID: 28003362
8. the interaction between nephrin and MAGI-1 regulates Rap1 activation in podocytes to maintain long term slit diaphragm structure PMID: 27707879
9. These findings ascribe a new function to SLAT, and identify Rap1 as a target of SLAT function in TCR-mediated inside-out signaling. PMID: 26483383
10. Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature PMID: 26714318
11. Rap1 deficiency impaired T-cell homeostasis. PMID: 26634692
12. Rap1 promotes endothelial mechanosensing complex formation, NO release and normal endothelial function PMID: 25807985
13. these data show that Treg degrade ATP to adenosine via CD39, attracting DC by activating Epac1-Rap1-dependent pathways. PMID: 25780038
14. Phosphorylation of synaptic GTPase-activating protein (synGAP) by Ca2+/calmodulin-dependent protein kinase II (CaMKII) and cyclin-dependent kinase 5 (CDK5) alters the ratio of its GAP activity toward Ras and Rap GTPases. PMID: 25533468
15. PI3-kinase gamma promotes Rap1a-mediated activation of myeloid cell integrin alpha4beta1, leading to tumor inflammation and growth. PMID: 23565202
16. Rap1 has distinct patterns of signaling in normal vascular morphogenesis and dysfunction. (Review) PMID: 23911990
17. Rap1 inhibits cell migration by suppression of RhoA activity in response to TGF-beta1. PMID: 23559363
18. Rap1 signaling enables plasticity by regulating L-type calcium channels at cortico-amygdala synapses. PMID: 23616533
19. Talin1 and Rap1 are critical for resorptive function, and their selective inhibition in mature osteoclasts retards pathological bone loss. PMID: 23230271
20. Rap1 activation restricts autoimmune T cell-mediated pathology through enhancing tolerance. PMID: 22688423
21. demonstrate that in rap1-deficient T cells, signaling by the ERK and p38 kinases is increased following activation by different stimuli leading to increased intracellular accumulation and secretion of cytokines PMID: 22695258
22. Id-1 maintains the GTPase activity of Rap1. PMID: 22647934
23. both Rap1 and RhoA GTPases regulate the formation of filamentous actin through the interaction between actin and profilin, thereby collectively inducing the phagocytosis of SOZs in macrophages. PMID: 22194606
24. farnesylthiosalicylic acid-amide inhibits contact sensitivity through Rap1 inhibition PMID: 21716322
25. data demonstrate that Rap1a activation by p38 MAPK and CalDAG-GEFI is involved in E-selectin-dependent slow rolling and leukocyte recruitment PMID: 21480213
26. Data show that Rap1 regulated the plasma membrane localization of NCad and NCad rescued radial polarization when Rap1 was inhibited. PMID: 21516100
27. cAMP-responsive Rap1 guanine nucleotide exchange factor, Epac, induces smooth muscle relaxation by down-regulation of RhoA activity PMID: 21454546
28. demonstrate that pharmacological activation of Epac-Rap signaling using acetoxymethyl-8-pCPT-2'-O-Me-cAMP preserves cell adhesions during hypoxia in vitro PMID: 21493776
29. Rap1A increases the frequency of natural Treg in the thymus via LFA-1- independent mechanisms but affects the frequency of peripheral Treg predominantly in an LFA-1-dependent manner. PMID: 20864093
30. maintenance of T cell Rap1 signaling in murine T cells reduces disease incidence and severity in collage-induced arthritis, which are associated with specific defects in T cell effector function. PMID: 20662068
31. IL-8-induced NAADP production is mediated by CD38 activation through the actions of cAMP/Epac/protein kinase A/Rap1 in LAK cells, and NAADP plays a key role in Ca(2+) signaling of IL-8-induced LAK cell migration PMID: 20442403
32. findings reveal the several critical steps of Rap1, which are RAPL-dependent and -independent, in lymphocyte trafficking PMID: 19965628
33. The results indicate that afadin has a novel role in PDGF-induced directional cell movement, presumably in cooperation with active Rap1 and SHP-2. PMID: 19887591
34. show that Rap1 activation is important for circulating lymphoma cells to enter tissues and form tumors in vivo. PMID: 19838206
35. These data describe for the first time protective effects for Rap1-dependent signaling against ventilator-induced lung injury and pulmonary endothelial barrier dysfunction. PMID: 19850733
36. CTLA-4 activates Rap1, and we propose that intracellular signals from CTLA-4 antagonize CD28, at least in part, at the level of Rap1 PMID: 15870282
37. Rap1A plays role in the regulation of integrins. PMID: 16382154
38. TIMP-2 mediated alteration in cell morphology requires Rap1, TIMP-2 may recruit Rap1 to sites of actin cytoskeleton remodeling necessary for cell spreading, and enhanced cell adhesion by TIMP-2 expression may hinder cell migration PMID: 16716258
39. Despite 95% amino acid sequence identity, similar intracellular distribution, and broad tissue distribution, Rap1a and 1b are not functionally redundant but rather differentially regulate certain cellular events. PMID: 18056377
40. The results suggested that deregulated constitutive Rap1 activation caused abnormal expansion of DP thymocytes, bypassing the pre-T-cell receptor and eventually leading to Notch1 mutations and Notch-dependent T-cell acute lymphoblastic leukemia. PMID: 18180377
41. Rap1a-mediated suppression of synaptic transmission enables plasticity in the cortico-amygdala pathway, which is required for fear learning with a moderately aversive unconditional stimulus. PMID: 18305243
42. our findings are consistent with the model describing the connection of c-Cbl to the cytoskeletal rearrangements via two pathways, one of which is mediated by PI3K and Rac1, and the other, by CrkL/C3G, Rap1 and Rac1 PMID: 18403249
43. Results indicate that Rap1, activated by PDGF, is recruited to leading edges and that Rac1 is thereby activated locally at peripheral ruffles; this process is pivotal for the PDGF-induced formation of leading edge structures and cell movement. PMID: 18422604
44. GTP-Rap1 is required for pancreatic amylase release. Rap1 activation not only mediates the cAMP-evoked response via Epac1 but is also involved in CCK- and carbachol-induced amylase release, with their action most likely mediated by CalDAG-GEF III. PMID: 18577515
45. Results suggest that Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls endothelial cell functions. PMID: 18625726
46. Rap1a and Rap1b are essential for the conformational activation of beta1-integrins in endothelial cells PMID: 18805968
47. Results are consistent with a cAMP/Epac2/Rap1-mediated signaling that could exert its action, among others, through RA-RhoGAP to promote the progression of spermatogenesis. PMID: 18937323
48. JAM-A dimerization facilitates formation of a complex with Afadin and PDZ-GEF2 that activates Rap1A, which regulates beta1 integrin levels and cell migration. PMID: 19176753
49. phosphorylation of Rap1GAP by protein kinase A plays an important role in striatal neurons by modulating Rap1 actions PMID: 19218462
50. These results suggest that Rap-1 is activated upon CTLA-4 ligation and mediates inhibitory signals through prevention of immunological synapse formation. PMID: 19490760

Show More

Hide All

KEGG: mmu:109905

STRING: 10090.ENSMUSP00000088174

UniGene: Mm.101922