Recombinant Mouse Receptor activity-modifying protein 2 (Ramp2), partial

Code CSB-YP892990MO
MSDS
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Source Yeast
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Code CSB-EP892990MO
MSDS
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Source E.coli
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Code CSB-EP892990MO-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP892990MO
MSDS
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Source Baculovirus
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Code CSB-MP892990MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Ramp2
Uniprot No.
Alternative Names
Ramp2; Receptor activity-modifying protein 2
Species
Mus musculus (Mouse)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.
Gene References into Functions
  1. The AM-RAMP2 system exerts crucial vasoprotective effects after vascular injury and could be a therapeutic target for the treatment of vascular diseases. PMID: 28324104
  2. Results provide in vivo evidence of a role for RAMP2 in placental development distinct from the RAMP2-calcitonin receptor-like receptor/adrenomedullin signaling paradigm; decreases Pthr1 expression and causes a blunted response to systemic parathyroid hormone; and identify additional pathways underlying the endocrine and fertility defects of the previously characterized Ramp2 heterozygous adult females. PMID: 28727763
  3. the Adrenomedullin-RAMP2 system regulates vascular integrity, whereas RAMP2 deletion promotes vascular permeability PMID: 27307317
  4. RAMP2 is essential for early vascular development and knockout-mice die in utero. PMID: 25264174
  5. These results indicate the AM-RAMP2 system works to protect nerve cells from both acute and chronic cerebral ischemia by maintaining cerebral blood flow suppressing oxidative stress, and in the case of chronic ischemia, enhancing capillary growth. PMID: 25252154
  6. It is not only an angiogenesis factor, but maintains hemostasis of blood vessels and organs. PMID: 24813793
  7. The AM-RAMP2 system is a key determinant of vascular integrity and homeostasis from prenatal stages through adulthood. PMID: 23355623
  8. These data demonstrate that the adrenomedullin-RAMP2 system is essential for cardiac metabolism and homeostasis. PMID: 23297372
  9. Adrenomedullin-RAMP2 system is the potential target for the induction of liver sinusoidal endothelial cells. PMID: 21782867
  10. this work reveals an essential role for RAMP2 in endocrine physiology and provides the first in vivo evidence for a physiological role of RAMP2 beyond that of AM/CLR signaling PMID: 21566080
  11. expressed in osteoclast-like cells PMID: 15691893
  12. RAMP2 plays a key role in the sensitivity and potency of AM-induced hypotensive responses via the AM1 receptor. PMID: 16373602
  13. RAMP2 and RAMP3 have distinct physiological functions throughout embryogenesis, adulthood, and old age PMID: 17470425
  14. RAMP2 is a key determinant of the effects of AM on the vasculature and is essential for angiogenesis and vascular integrity. PMID: 18097473
  15. the vascular smooth muscle AM1 receptor RAMP2 acts at a local level to protect against hypertension-induced vascular hypertrophy and inflammation PMID: 19858409

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Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
RAMP family
Tissue Specificity
Ubiquitous. Expressed predominantly in embryonic brain, lung and gut and in adult heart, lung, skeletal muscle and brain.
Database Links
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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