RAMP2 encodes the receptor activity - modifying protein 2, also commonly known as RAMP - 2. It plays a crucial role in the function of various G - protein coupled receptors. By interacting with calcitonin receptor - like receptor (CLR), RAMP2 forms the adrenomedullin receptor. This complex is involved in the calcitonin gene - related peptide (CGRP) and adrenomedullin signaling pathways.
In terms of diseases, RAMP2 has been linked to cardiovascular disorders due to its role in vasodilation and blood pressure regulation. Drug development efforts are underway to target the RAMP2 - CLR complex, aiming to modulate its activity for therapeutic benefits in conditions such as hypertension and heart failure.
RAMP2 Antibody (CSB-PA019305LA01HU)
Validated Data
IHC image of CSB-PA019305LA01HU diluted at 1:500 and staining in paraffin-embedded human lung tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of A549 cells with CSB-PA019305LA01HU at 1:230, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
The following RAMP2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
RAMP2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA019305GA01HU | RAMP2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA827979 | RAMP2 Antibody | Human | ELISA,WB |
CSB-PA019305LA01HU | RAMP2 Antibody | Human | ELISA, IHC, IF |
CSB-PA019305LC01HU | RAMP2 Antibody, FITC conjugated | Human | |
CSB-PA019305LD01HU | RAMP2 Antibody, Biotin conjugated | Human | ELISA |
RAMP2 Proteins for Cavia porcellus (Guinea pig)
Code | Product Name | Source |
---|---|---|
CSB-YP848128GU CSB-EP848128GU CSB-BP848128GU CSB-MP848128GU CSB-EP848128GU-B |
Recombinant Guinea pig Receptor activity-modifying protein 2 (RAMP2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RAMP2 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP862354RA CSB-EP862354RA CSB-BP862354RA CSB-MP862354RA CSB-EP862354RA-B |
Recombinant Rat Receptor activity-modifying protein 2 (Ramp2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RAMP2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP892990MO CSB-EP892990MO CSB-BP892990MO CSB-MP892990MO CSB-EP892990MO-B |
Recombinant Mouse Receptor activity-modifying protein 2 (Ramp2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RAMP2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF019305HU | Recombinant Human Receptor activity-modifying protein 2 (RAMP2) | in vitro E.coli expression system |
CSB-YP019305HU1 CSB-EP019305HU1 CSB-BP019305HU1 CSB-MP019305HU1 CSB-EP019305HU1-B |
Recombinant Human Receptor activity-modifying protein 2 (RAMP2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |