Recombinant Mouse Receptor-type tyrosine-protein phosphatase F (Ptprf), partial

Code CSB-YP019053MO
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Source Yeast
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Code CSB-EP019053MO
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Source E.coli
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Code CSB-EP019053MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP019053MO
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Source Baculovirus
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Code CSB-MP019053MO
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Ptprf
Uniprot No.
Alternative Names
Ptprf; Lar; Receptor-type tyrosine-protein phosphatase F; EC 3.1.3.48; Leukocyte common antigen related; LAR
Species
Mus musculus (Mouse)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity.
Gene References into Functions
  1. loss of LAR activity resulted in reduced activity of CDK1. PMID: 27352860
  2. Study has identified LAR as a regulator of key signaling pathways, including mTOR and JNK, and has significantly expanded the number of proteins regulated downstream of LAR phosphatase activity. PMID: 27074791
  3. This study demonstrates the crucial role of LAR in restricting regrowth of injured CNS axons PMID: 25220840
  4. Ptprs and Ptprf deficiency affects mandibular cell proliferation. PMID: 23863482
  5. Inhibition of LAR attenuates palmitate-induced insulin resistance in myotubes. PMID: 22899729
  6. Deletion of LAR in knock-out mice or blockade of LAR with sequence-selective peptides significantly overcomes neurite growth restrictions of chondroitin sulfate proteoglycan in neuronal cultures. PMID: 21976490
  7. the crystal structures of the first and second immunoglobulin-like domains of the Drosophila type IIa receptor Dlar and its mouse homolog LAR were reported. PMID: 21402080
  8. LAR reduces the basal c-Abl activity thereby allowing for platelet derived growth factor beta receptor kinase activation PMID: 21300149
  9. LAR deficiency affected the differentiation & expansion of immature thymocytes, positive & negative selection, & a lower Ca2+ response. LAR is an important modulator of TCR signaling that controls thymocyte differentiation. PMID: 20186877
  10. LAR PTPase domains play distinct functional roles in phosphorylation and dephosphorylation PMID: 12496362
  11. PTP alpha is required for integrin-proximal events and phosphorylates FAK PMID: 12515828
  12. In conclusion, behavioural testing of the LAR tyrosine phosphatase-deficient mice revealed a spatial learning impairment and a significant increase in activity. PMID: 15302123
  13. LAR enhances retinal ganglion cell neurite initiation whilst suppressing retinal ganglion cell survival PMID: 15932596
  14. Results introduce leukocyte common antigen-related (LAR) protein tyrosine phosphatase (PTP) as the first PTP found to be expressed in dentate progenitors and point to inhibition of LAR as a potential strategy for promoting neurogenesis. PMID: 16488625
  15. Here, we report rapid and efficient construction of PTPRF and NWC TgVs without using restriction endonucleases. PMID: 17498650

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Subcellular Location
Membrane; Single-pass membrane protein.
Protein Families
Protein-tyrosine phosphatase family, Receptor class 2A subfamily
Tissue Specificity
Expressed in the cell of the T lineage but not in cells of any other hemopoietic lineage.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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