Recombinant Mouse Renin-1 (Ren1)

1. This study reveals that the human renin protein is able to complement the mouse Ren1d(-/-) non-granulated defect and suggests that granulopoiesis requires a structural motif that is conserved between the mouse Ren1d and human renin proteins. PMID: 29123029
2. These observations demonstrate that activation of the renin-angiotensin system (RAS) promotes colitis in a blood pressure independent manner. Angiotensin II appears to drive colonic mucosal inflammation by promoting intestinal epithelial cell apoptosis and mucosal TH17 responses in colitis development. PMID: 27271344
3. Mice homozygous for the Ren1c gene disruption (Ren1c-/-) display several morphological and physiological abnormalities, including poorly developed renal medulla, papillary atrophy, hydronephrosis, inability to concentrate the urine, polyuria, polydipsia, renal failure, and anemia. PMID: 28533331
4. renin inhibition with aliskiren leads to improved ischemia-induced neovascularization that is not dependant on blood pressure lowering PMID: 26295797
5. Calcineurin inhibitors induce production of renin in the collecting ducts that may contribute to decreased renal blood flow and increased VEGF production. PMID: 26502369
6. AKR1B7 is expressed within the renin cell throughout development and perturbations to homeostasis, and AKR1B7 is regulated by cAMP levels within the renin cell. PMID: 26180185
7. Characterize hypertension produced by transduction with a renin1-coding adeno-associated virus. PMID: 26108870
8. Cx40 is a requirement for the pressure control of renin secretion irrespective of the localization of renin secreting cells. PMID: 25241776
9. Deletion of renin in the vasculature resulted in neonatal mortality that could be rescued with daily injections of saline PMID: 26246508
10. Cells of renin lineage (CoRL) serve as progenitors for other cells in kidney disease characterized by both glomerular and tubulointerstitial injury. PMID: 26062877
11. Specific cross-linking of the high affinity immunoglobulin epsilon receptor on the surface of bone marrow-derived mast cells and heart mast cells elicits the release of enzymatically active renin protein. PMID: 24262755
12. Blood pressure homeostasis is regulated through transcriptional cis elements controlling renin activity. PMID: 24734888
13. extraglomerular renin lineage cells represent a major source of repopulating cells for reconstitution of the intraglomerular mesangium after injury PMID: 24904091
14. Data indicate the role of renin in hypertension linked to loss of connexin 40 (Cx40). PMID: 24614215
15. Renin secretory granules possess integral lysosomal proteins, confirming that they are indeed modified lysosomes PMID: 23635510
16. Data indicate that in 1-day-old Task3-/- mice, renal renin concentration was lower than in wild-type mice. PMID: 23698720
17. Overexpression of renin in the kidney collecting duct elevated blood pressure. Results suggest that collecting duct-derived renin has the potential to modulate blood pressure independent of the systemic renin-angiotensin system PMID: 23702969
18. renin is released by mechanisms similar to compound exocytosis. PMID: 23235568
19. Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation. PMID: 23401498
20. deletion of Vhl shifts the phenotype of juxtaglomerular cells from a renin- to erythropoietin-secreting cell type, presumably in response to HIF-2 accumulation PMID: 23393316
21. The enhanced expression of bone renin and angiotensin II plays an important role in the pathology of age-related osteoporosis. PMID: 22785482
22. Data show that COUP-TFII is involved in the control of renin gene expression. PMID: 22645148
23. the mouse-renin gene is regulated by apurinic/apyrimidinic-endonuclease 1 (APE1/Ref-1) via recruitment of histone deacetylase 1 corepressor complex PMID: 22441348
24. Changes in preglomerular blood pressure may be an important mediator of the influence of salt intake on the number and distribution of renin-producing cells in the kidney. PMID: 22357914
25. Data suggest that Western diets (i.e., diets high in saturated fat and or salt) down-regulate expression of renin in kidney. PMID: 21499941
26. It was concluded that both Nr2f2 and Nr2f6 negatively regulate renin promoter activity, but may do so by divergent mechanisms. PMID: 22278040
27. VAMP2 and VAMP3 are expressed in JG cells, but only VAMP2 is targeted to renin-containing granules and mediates the stimulatory effect of cAMP on renin exocytosis. PMID: 21708949
28. genetic disruption of beta-adrenergic receptors reduces basal renin expression along the developing preglomerular tree and in adult kidneys PMID: 21389089
29. Renin-angiotensin-aldosterone system components are upregulated under endothelin blockade. PMID: 20093323
30. cathepsin B-deficient mice exhibit no differences compared with controls in their ability to generate active renin, and our results do not support CTSB as the processing enzyme in mice PMID: 20164204
31. Altered renin synthesis and secretion in the kidneys of heterozygous mice with a null mutation in the TGF-beta(2) gene. Renal renin mRNA and protein levels were higher in mutant mice under hydrated or dehydrated conditions. PMID: 12381922
32. Review. Role of the local renin-angiotensin system in cardiac damage, focussing on transgenic animal models. PMID: 12431444
33. identification of several binding sites within the renin enhancer region that are essential for high level expression of Ren-1 gene PMID: 12591615
34. renin transcription is regulated by TNFalpha, which is regulatedby NFkappaB PMID: 14563845
35. aldosterone exerts a direct positive effect on renin gene expression at the cellular level probably by stabilizing renin mRNA. PMID: 14583438
36. NO independent of its exact source permits the macula densa pathway of renin secretion to function normally. PMID: 15075180
37. Transgenic rats overexpressing the mouse Ren1 gene developed myocardial hypertrophy independent of calcineurin. PMID: 15322704
38. Review. Transcription of renin genes is subject to complex developmental and tissue-specific regulation. A sequence highly homologous to the mouse enhancer is also found in the human and rat renin genes. PMID: 15545507
39. renin is the only enzyme capable of maintaining plasma angiotensins and that renin expression in the kidney is very tightly regulated at the mRNA level. PMID: 15563565
40. LXR(alpha) and LXR(beta) regulate renin expression in vivo by directly interacting with the renin promoter PMID: 16007255
41. the renin enhancer is critical for renin gene expression and physiological sequelae, including response to alteration in salt intake PMID: 16895910
42. Stimulation of renin by furosemide was not affected by mPGES1 deficiency. PMID: 17442791
43. The renin enhancer located 2.7 kb upstream of the renin gene is critical for replenishment of renin stores and response in renin to a chronic in vivo stimulus PMID: 17846348
44. This study describes the three-dimensional development of renin expression in mouse kidneys during fetal and postnatal life. PMID: 17898695
45. Ren1c(-/-) mice are lean, insulin sensitive, and resistant to diet-induced obesity without changes in food intake and physical activity. The lean phenotype is likely due to a higher metabolic rate and gastrointestinal loss of dietary fat. PMID: 18054319
46. This study showed that the Ren-1c enhancer does not regulate the rate of promoter activity, but rather increases the probability of achieving an active transcriptional state. PMID: 18307722
47. Connexin45 is expressed in the juxtaglomerular apparatus and is involved in the regulation of renin secretion and blood pressure. PMID: 18579650
48. expression of the human VDR in mouse juxtaglomerular cells reduced renin expression without affecting calcium or parathyroid hormone status PMID: 19034301
49. Continuous activation of the brain renin-angiotensin system impairs cognitive function via stimulation of the angiotensin II type 1 receptor with a decrease in cerebral surface blood flow and an increase in oxidative stress. PMID: 19047580
50. CBP and p300 are essential for renin cell identity and morphological integrity of the kidney. PMID: 19252086

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KEGG: mmu:19701

STRING: 10090.ENSMUSP00000092135

UniGene: Mm.220955