Recombinant Mouse Semaphorin-3F (Sema3f)

1. data suggest that Sema3f and Nrp2 are dispensable for the exclusion of vessels from the cap mesenchyme during kidney development. PMID: 28929539
2. Sema3f is suppressed in outer nuclear layer in very low-density lipid-receptor deficient retina. PMID: 28373097
3. Sema3F functions as an unconventional Sema3 that promotes extraembryonic angiogenesis by inhibiting the Myc-regulated synthesis of Thbs1 in visceral yolk sac epithelial cells. PMID: 28729362
4. Nrp2 deficiency increased blood vessel permeability and decreased lymphatic vessel drainage during inflammation, highlighting the importance of the NRP2/SEMA3F pathway in the modulation of tissue swelling and resolution of postinflammatory edema. PMID: 27751443
5. Sema3F plays important roles in the development of neuronal circuitry underlying the regulation of some aspects of anxiety and fear responses. PMID: 26856818
6. The authors demonstrate that expression of Semaphorin-3F in the outer hair cell region inhibits type I spiral ganglion neuron process extension by activating Neuropilin-2 receptors expressed on spiral ganglion neurons. PMID: 26302206
7. the embryonically developed wiring deficits in Sema3F mutants persist until adulthood PMID: 25874621
8. Sema4A promotes Th1 and Th17 differentiation and increases adhesive activation of T cells to endothelial cells, even in the presence of IFN-beta. PMID: 24439904
9. Sema3F is secreted by early-arriving axons of olfactory sensory neurons and is deposited at the anterodorsal olfactory bulb to repel Nrp2-positive axons that arrive later. PMID: 20550939
10. These data suggest that Sema3F plays a relatively restricted, if any, role in its receptor expression and postnatal development of the somatosensory cortex, the cerebellum, and the main olfactory system. PMID: 20006658
11. Sema3F is the principal ligand for Npn-2-mediated axon guidance events in vivo and is a critical determinant of limbic and peripheral nervous system circuitry PMID: 12890759
12. Sema3F alternatively spliced isoforms share common axonal chemorepulsive properties and binding to neuropilin receptors, and are found to regulate endothelial cell morphology by remodeling lamellipodial protrusions. PMID: 14572462
13. We describe a related signaling pathway involving secreted class 3 semaphorins, neuropilins, and a plexin receptor, PlexinD1, expressed by endothelial cells PMID: 15239958
14. Using sema3F-/- mice, we show that Sema3F is critical for vomeronasal sensory neuron axonal fasciculation and for segregation of these sensory afferents from the main olfactory system and lamina-specific targeting of olfactory sensory axons PMID: 15483127
15. Npn2/Sema3f signaling guides neural crest migration through the somite. PMID: 16319111
16. Genetic evidence for a Nrp2-Sema3f interaction as a determinant of the wiring of axons of gucy2d+ neurons into the unusual configuration of necklace glomeruli. PMID: 17942483
17. An important regulator of the ventral tangential cell migration stream, confining the migrating neurons on the telencephalon surface by repelling from the deeper domain. PMID: 18434520
18. Sema 3D and Sema 3F genes are overlappingly and distinctly expressed in the developing parathyroid and thymus, respectively, and they might play roles in the interactions between these organs and surrounding tissues PMID: 18489001
19. Semaphorin3F induces significant growth cone collapse of temporal, but not nasal, RGCs expressing high levels of Neuropilin-2. PMID: 18942144
20. Data demonstrate that methyl-CpG binding protein 2 deficiency disrupts the establishment of neural connections before synaptogenesis by altering semaphorin 3F function. PMID: 19628041
21. Soluble neuropilin-2Fc did not inhibit repulsion but increased the repellent effect of semaphorin 3F. PMID: 19790074

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KEGG: mmu:20350

STRING: 10090.ENSMUSP00000079400

UniGene: Mm.12903