Recombinant Mouse Sodium/calcium exchanger 1 (Slc8a1), partial

1. Pin1 serves as a modulator of SERCA2a and Na(2+)/Ca(2+) exchanger 1 Ca(2+) handling proteins, with loss of function resulting in impaired cardiomyocyte relaxation PMID: 29018025
2. NCX1 (and NCX2) are expressed in neurons that regulate the motility of the gastric fundus. PMID: 26787195
3. Induced overexpression of NCX1 attenuated pressure overload-induced pathological cardiac remodelling PMID: 27229460
4. The heterogeneous expression of multiple types of Na(+)/Ca(2+) exchangers and the quantitative differences found in calcium concentration, together with other risk factors specific to dopaminergic neurons such as dopamine oxidation resulting in oxidative stress, may drive these cells to undergo selective degeneration. PMID: 27020658
5. NCX1 is dispensable for osteoclast differentiation. PMID: 27942992
6. the functional role of NCX on gastrointestinal motility PMID: 27928109
7. These results suggested that NCX1 may play an important role in the proper spatial distribution of LTCC and JP2 in T-tubules in the context of pressure-overloading. PMID: 27789286
8. In this study, authors demonstrate that NCX1 regulates gastric fundus motility. PMID: 27816547
9. NCX1 and NCX2 play important roles in ileal motility and suggest that NCX1 and NCX2 regulate the motility in the ileum by controlling the sensitivity of smooth muscles to ACh and SP. PMID: 27411318
10. Data show that transforming growth factor beta1 (TGFbeta1) is a powerful stimulator of both, store operated Ca2+ entry (SOCE) and Na+/Ca2+-exchanger activity in megakaryocytes. PMID: 27441368
11. dobutamine upregulates of voltage-gated Na+ channel function and Na+ influx-induced activation of the reverse mode of NCX PMID: 26314851
12. JAK3 deficiency is followed by down-regulation of cytosolic Ca(2+) release, receptor and store operated Ca(2+) entry and Na(+)/Ca(2+) exchanger activity in dendritic cells. PMID: 26279433
13. Results suggested that down-regulation of hippocampal NCX1 expression is associated with pentylenetetrazole-induced kindling seizure development PMID: 26220386
14. TRPC3-NCX micro/nanodomain communication as determinant of cardiac contractility and susceptibility to arrhythmogenic stimuli. PMID: 25631581
15. cellular Ca accumulation hinders spontaneous depolarization in the NCX knockout sinoatrial node, possibly by inhibiting L-type Ca currents. PMID: 26195795
16. thrombin-induced ERK1/2 activation required NADPH oxidase 2-mediated reactive oxygen species (ROS) production, and reverse-mode NCX inhibitors and NCX1 siRNA suppressed thrombin-induced ROS production PMID: 25979335
17. NCX1 plays an important role in smooth muscle motility in the mouse distal colon. PMID: 25427675
18. There is a functional role of sodium-calcium exchanger SLC8A1 in human atrial and atrioventricular nodal conduction as suggested by genetically modified mouse models. PMID: 25055868
19. Negative regulation of NCX1- mediated renal Ca(2+) absorption by IFNgamma may significantly contribute to the altered Ca(2+) homeostasis in IBD patients and to IBD-associated loss of bone mineral density PMID: 25648899
20. human osteoblasts and osteoblasts from Ano6(-/-) and WT mice, we demonstrate that NCX1 requires Ano6 to efficiently translocate Ca(2+) out of osteoblasts into the calcifying bone matrix PMID: 25589784
21. muscle-specific deletion of the Slc8a1 (NCX1) gene diminished hind-limb pathology in Sgcd(-/-) mice. PMID: 24662047
22. majority of NCX1KO cells displayed an irregular and a significantly reduced frequency of spontaneous Ca(2+) signals PMID: 23761399
23. Our results indicated that in AsTg mice, the Ca(2)(+) response to the acid was facilitated in macrophages by a low threshold of ASIC1 and NCX1 molecules and the activity of these channel was possibly regulated by adiponectin. PMID: 24084100
24. The decrease of miR-1 and increase of AnxA5 appear as important modulators of NCX1 expression and activity during heart failure. PMID: 23436819
25. NCX1.3 overexpression is associated with abnormal urination owing to enhanced Ca(2+) influx via reverse mode NCX leading to prolonged, propagating spontaneous Ca(2+) release events and potentiation of spontaneous urinary bladder smooth muscle contraction PMID: 23703524
26. the use of genetic-modified mice for NCX1, NCX2, and NCX3 represents a fruitful strategy to characterize the physiological role exerted by NCX in CNS PMID: 23224882
27. Functional studies, as well as mRNA and protein expression analyses, revealed that NCX1 and NCX3, but not NCX2, were divergently modulated during OPC differentiation into oligodendrocyte. PMID: 23224890
28. NCX1 is a key component of certain distinct signaling pathways that activate VSM contraction in response to stretch (i.e., myogenic response) and to activation of certain G-protein-coupled receptors. PMID: 23224892
29. Toward an understanding of the complete NCX1 lifetime in the cardiac sarcolemma. PMID: 23224893
30. Inhibition of the reverse NCX1 completely prevents calcium (Ca2+) increase and spheroid formation in the presence of reactive oxygen species (ROS), suggesting that reverse NCX1 is responsible for the bulk of Ca2+ influx. PMID: 22933787
31. The Akita(ins2) type 1 diabetic model is protected against systolic failure due to increased NCX1 expression via a CXCR4/NF-kappaB pathway. PMID: 22610174
32. TRPV6, NCX1, and CaBP-9k in the fetal placenta and CaBP-28k in the maternal placenta may play key roles in controlling calcium transport across the placenta during pregnancy. PMID: 22407925
33. NCX current was recorded from subepicardial (EPI) myocytes and subendocardial (ENDO) myocytes isolated from sham operation (SO) mice and heart failure (HF) mice. PMID: 21750914
34. We studied the proarrhythmic potential and mechanisms of enhanced NCX activity in transgenic mice with cardiomyocyte-directed overexpression of NCX . PMID: 22327339
35. We engineered mice in which the phosphomimetic phospholemman S68E mutant (inhibits NCX1 but not Na(+)-K(+)-ATPase) was constitutively overexpressed in a cardiac-specific manner. PMID: 22081699
36. Data suggest that the CaMKIIdeltaB-induced imbalance between NCX1 and SERCA2 is partially responsible for the disturbance of intracellular Ca(2) homeostasis and the pathological process of heart failure. PMID: 21931829
37. an increase in the NCX1 mRNA due to the apoptosis induction is not regulated by HIF-1alpha PMID: 21613675
38. A single amino acid substitution in Ncx1 results in circulation defects and defective placentation. Action potentials and the Ca2+ homeostasis were diminished so that cardiomyocytes derived from mutant embryos were fibrillating and contracting randomly. PMID: 21302256
39. Specific genetic knockdown of NCX attenuated calcium mediated afterdepolarization and complex electrogram. PMID: 21168206
40. Sodium inactivation and reverse sodium-calcium-ion (Ca2+) exchange modulate divalent Ca2+- release in Ncx-deficient cardiomyocytes by triggering ryanodine receptors. PMID: 20643777
41. Under catecholamine stress when [Na+]i is high, phospholemman minimizes [Na+]i overload by relieving its inhibition of Na+-K+-ATPase and preserves inotropy by simultaneously inhibiting Na+/Ca2+ exchanger. PMID: 21193587
42. Myocardial NCX1 does not mediate changes in blood pressure, but is one of the mediators for left ventricular global dysfunction and cardiomyocyte injury in chronic intermittent hypoxia. PMID: 20947716
43. Functional coupling between the vascular alpha2 Na(+) pump and NCX1 is a critical molecular mechanism for salt-induced blood pressure elevation. (review) PMID: 21048395
44. The Ncx-1-43LUC mES cell line is a novel tool for monitoring early cardiac differentiation in vivo using noninvasive bioluminescence imaging. PMID: 20109065
45. in NCX1(SM-/-) myocytes, reduced Ca(2+) entry via NCX1 lowers cytosolic calcium, thereby reducing protein kinase C activation that lowers L-type Ca2+ channel activation PMID: 20081108
46. In NCX1(SM-/-) mouse artery myocytes, the reduced Ca(2+) entry via NCX1 may lower cytosolic Ca concentration and thereby reduce muscle tonus and blood pressure PMID: 20173044
47. This work has provided insight into the intracellular signaling pathways and transcription factors regulating Ncx1 gene expression in a chronically beta-AR-stimulated heart. PMID: 19945464
48. Results show that the Na(+)/Ca(2+) exchanger NCLX is enriched in mitochondria, where it is localized to the cristae. PMID: 20018762
49. The Na+-Ca2+ exchanger is essential for the action of cardiac glycosides in embryonic mouse myocytes PMID: 11861419
50. Plasma membrane Ca2+-ATPase and NCX1 Na+/Ca2+ exchanger expression in distal convoluted tubule cells mediate calcium efflux. PMID: 12060584

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KEGG: mmu:20541

STRING: 10090.ENSMUSP00000083725

UniGene: Mm.265834