Recombinant Mouse Suppressor of cytokine signaling 3 (Socs3)

1. SOCS3 impacts on IEC turnover following T. muris infection, potentially through enhancement of IDO. IDO may dampen the immune response which can drive intestinal epithelial cell hyperproliferation in the absence of SOCS3, demonstrating the intricate interplay of immune signals regulating mucosal homeostasis, and suggesting a novel tumour suppressor role of SOCS3. PMID: 28508554
2. The findings of this indicated that co-deletion of PTEN and SOCS3 results in modest but measureable enhancement of early regeneration of DRG axons following crush injury. PMID: 29458059
3. Our findings suggest a role for murine cytomegalovirus (MCMV)-related stimulation of SOCS1 and SOCS3 in the progression of retinal disease during ocular, but not systemic, MCMV infection. PMID: 29976680
4. Lentivirusmediated overexpression of SOCS3 was revealed to ameliorate neutrophilic airway inflammation by inhibiting pulmonary Th17 responses in mice with chronic Pseudomonas aeruginosa lung infections. PMID: 29393363
5. These data demonstrate that loss of SOCS3 in cardiomyocytes promotes deoxycorticosterone-acetate -salt-induced cardiac remodeling and inflammation. PMID: 29763909
6. In the present study, we investigated the hypothesis that SOCS3 expression in the VMH could exert an important role regulating the metabolic changes typically observed during pregnancy and lactation. PMID: 28987511
7. SOCS3 was targeted by miR30a- 5p in allergic rhinitis PMID: 29471302
8. SOCS3 was upregulated in lung CD4+ T cells in a mouse model of chronic PA lung infection and exogenous SOCS3 suppressed Th17-mediated neutrophil recruitment in vitro. PMID: 28560450
9. findings show SOCS3 does not appear to mediate the early inflammatory or leucine-induced changes in protein synthesis in skeletal muscle PMID: 28554144
10. The strength of long bones is determined by coalescence of trabeculae during corticalization.This process is regulated by SOCS3 via a mechanism dependent on IL-6 and expression of sex hormones. PMID: 28993616
11. High SOCS3 expression is associated with glioma. PMID: 26967393
12. Mechanistic analysis indicated that E47 activated expression of the transcription factor Spi-B and the suppressor of cytokine signaling 3 (SOCS3), which both downregulated Foxp3 expression. These findings demonstrate that the balance of Id3 and E47 controls the maintenance of Foxp3 expression in Treg cells and, thus, contributes to Treg cell plasticity. PMID: 27974197
13. Our results show, for the first time, that SOCS-3 regulates leptin-induced responses in cartilage PMID: 27716333
14. Loss of suppressor of cytokine (SOCS3) expression in mature muscle fibers increased the inflammatory response to myotoxic injury but did not impair muscle regeneration in either adult or old mice. Therefore, reduced SOCS3 expression in muscle fibers is unlikely to underlie impaired muscle regeneration. PMID: 27800152
15. Findings revealed a novel participation of SOCS3 regulating several endocrine and metabolic aspects. PMID: 28899903
16. Findings indicate that inactivation of the Rb family proteins (Rb, p107, and p130) in hematopoietic stem cells (HSCs) progressively impairs their homeostasis, which is rescued upon repression of suppressor of cytokine signaling 3 protein (Socs3) expression in triple knockout (TKO) HSCs. PMID: 28550162
17. Data suggest that, in B cell lymphoma, expression of MIRN30 is up-regulated in both granulocytic myeloid-derived suppressor cells and monocytic myeloid-derived suppressor cells; in B cell lymphoma, 3prime untranslated region of Socs3 appears to be direct target of MIRN30 in myeloid-derived suppressor cell differentiation. (MIRN30 = microRNA 30; Socs3 = suppressor of cytokine signaling 3 protein) PMID: 28605567
18. Cell type-specific, different roles for viral immediate early or early gene expression and/or viral tegument proteins in the early stimulation of SOCS1 and SOCS3 during murine cytomegalovirus infection. PMID: 28182772
19. oncostatin M mitigated the proliferation of Th17 cells and decreased the expression of IL-17 and IL-21; it promoted the activation of suppressor of cytokine signaling 3 (SOCS3), STAT3, and STAT5; observations suggest that OSM can inhibit Th17 differentiation by reciprocally controlling SOCS3, STAT3, and STAT5 PMID: 28093521
20. Results demonstrate a novel tunable form of cross-talk in which alveolar epithelial cells use Prostaglandin E2 (PGE2) as a signal to request SOCS3 from alveolar macrophages to dampen their endogenous inflammatory responses during infection. PMID: 27183597
21. Loss of SOCS3 significantly accelerated the pathology and inflammatory disease characteristic of SOCS1 deficiency. We propose a model in which SOCS1 and SOCS3 operate independently to control specific cytokine responses and together modulate the proliferation and activation of lymphoid and myeloid cells to prevent rapid inflammatory disease PMID: 27583437
22. This study showed that leptin resistant infertility is caused in part by the leptin signaling molecule SOCS3. Deletion of SOCS3 from brain neurons delays the onset of diet-induced infertility. PMID: 27383590
23. SOCS3 plays a divergent role in relation to local vs. systemic effects of Ang II on the vasculature. PMID: 27106041
24. These results indicate that Platelet-activating Factor -mediated endotoxin tolerance is initiated via IDO- and JAK/STAT-dependent expression of SOCS3. PMID: 28077574
25. critical negative regulator of alveolar bone loss in experimental periodontitis PMID: 27126447
26. expression in leptin receptor-positive cells contributes to fasting-induced hyperphagia and weight regain PMID: 27471877
27. a novel negative feedback loop mediated by STAT3-SOCS3, which is tightly controlled by SENP1 via de-SUMOylation of protein tyrosine phosphatase 1B (PTP1B), in IFN-gamma signaling, is reported. PMID: 27702761
28. Vasoproliferative retinopathies may benefit from a CNTF-dependent and SOCS3-mediated angiomodulatory effect. PMID: 27494343
29. this study shows that fungal pattern receptors share with other ITAM-coupled receptors the capacity to produce cross-inhibition through a mechanism involving STAT3 and induction of SOCS3 and IL-10, but that cannot be explained through type I IFN signaling PMID: 27709605
30. this study shows that suppression of IL-6/Stat3 pathway in dendritic cells by paeoniflorin is mediated via upregulation of Socs3 PMID: 27236299
31. Study indicated that SOCS3 suppresses complete polarization to M1 phenotype through blocking IL6 production, and Abeta-challenged primary-cultured microglia replicate the in vivo gene expression pattern of microglia in APPswe/PS1dE9 mice PMID: 27814300
32. Results identify unrecognized functions of Yes-associated protein (YAP) in preventing reactive astrogliosis and reveal a pathway of YAP- suppressor of cytokine signaling 3 (SOCS) for the negatively control of neuroinflammation. PMID: 26679195
33. SOCS3 serves as an immune modulator interfering with T cells and B cells, and SOCS3 may act as a predictive marker for immune modulation of mesenchymal stromal cells. PMID: 26318865
34. Signal transducer and activator of transcription 3 and suppressor of cytokine signaling 3 play important, yet unexpected, roles in NG2 cell proliferation and differentiation after spinal cord injury. PMID: 26804026
35. The results of this study showed that the role of SOCS3 in mediating pregnancy-induced metabolic adaptations. PMID: 26828039
36. Concentration of SOCS-3 protein and coimmunoprecipitation of SOCS-3 protein with both the IR-beta subunit as well as IRS-1 was found to be decreased by 4-HIL PMID: 26887316
37. CCR5 blockade suppresses B16 melanoma growth by inhibiting of IL-6-Stat3 signaling pathway via upregulation of SOCS3. PMID: 26047948
38. AHR plays protective roles against high-fat diet-induced hepatic steatosis and the subsequent lipotoxicity via direct transcriptional regulation of Socs3 gene expression. PMID: 26865635
39. The liver regenerative effects of HCM appear to be mediated by persistent and uninhibited expression of STAT3 in the liver, which results from decreased expression of SOCS3 PMID: 27102647
40. SOCS3 gene expression attenuates contact hypersensitivity by suppressing MMP12 production. PMID: 27015453
41. These results suggest that neuronal and glial cell SOCS3 limits pathological retinal angiogenesis by suppressing VEGF signaling. PMID: 26396267
42. Socs3 deletion in cortical neurons promotes sprouting of corticospinal axons after unilateral pyramidotomy, restoring skilled locomotion. PMID: 26598325
43. sleep deprivation increases levels in hematopoietic stem cells PMID: 26465715
44. SOCS3-deficient and sufficient B-lineage cell migration towards CXCL12 in vitro was undistinguishable, and B-lineage cell amoeboid motility within BM parenchyma was also unaffected by SOCS3-deficiency PMID: 26274929
45. RORalpha regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation PMID: 26243880
46. findings suggest that SOCS3 may represent a key factor that exacerbates the development of myocardial IRI. PMID: 26010537
47. The critical function of SOCS3 is as a negative regulator of MDSC development and function via inhibition of STAT3 activation. PMID: 25649351
48. mediates inhibition of TH17 cell differentiation by mesenchymal stem cells PMID: 25588866
49. SOCS3 is an inducible host factor that regulates virus egress during Ebola virus infection. PMID: 26246577
50. SOCS3 deficiency greatly alleviates IgG immune complex-induced generation of pro-inflammatory mediators in lungs. PMID: 26209606

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KEGG: mmu:12702

STRING: 10090.ENSMUSP00000059129

UniGene: Mm.3468