Recombinant Mouse Syntaxin-1A (Stx1a), partial

1. The role of syntaxin 1A in GLP1 release from intestinal cells as a response to external stimuli is reported. PMID: 28596237
2. Therefore, our work provides insights into differential functions of Stx1 in neuronal maintenance and neurotransmission, with the latter explored further into its functions in vesicle docking and fusion. PMID: 27466336
3. Syn-1A actions on newcomer SGs were partly mediated by Syn-1A interactions with newcomer SG VAMP8 PMID: 28031464
4. The results of this study suggested that STX1A plays an important role in social behavior through regulation of the OXTergic neural system. PMID: 27059771
5. syntaxin 1 and vesicle-associated membrane protein 1 are more suitable targets to abolish functional soluble N-ethylmaleimide-sensitive factor attachment protein receptor complexes PMID: 24604356
6. Although STX1A and STX1B share a basic function as neuronal t-SNAREs, STX1B but not STX1A is necessary for the regulation of spontaneous and evoked synaptic vesicle exocytosis in fast transmission. PMID: 24587181
7. we found that STX1A and STX1B play distinct roles in neuronal survival using PMID: 24666284
8. point mutation in syntaxin-1A causes abnormal regulation of neuronal plasticity and vesicle recycling and that the affected syntaxin-1A/CaMKII interaction is essential for normal brain and synaptic functions in vivo. PMID: 24136198
9. overall release efficiency of affected hippocampal neurons was severely impaired by reducing levels of Stx1, as demonstrated by a smaller readily releasable pool size, slower refilling rate of primed vesicles, and lower release probability. PMID: 24133272
10. CAPS1 binds to the full-length of cytoplasmic syntaxin-1 with preference to its "open" conformation, whereas Munc13-1 binds to the first 80 N-terminal residues of syntaxin-1. PMID: 23801330
11. The N-terminal syntaxin-1 domains mediate different functions in synaptic vesicle fusion, probably via formation of distinct Munc18/SNARE-protein complexes. PMID: 23188083
12. Direct interaction between syntaxin 1A and the Kv2.1 C-terminus is required for efficient insulin exocytosis and glucose-stimulated insulin secretion. PMID: 22411134
13. Nesca directly binds KIF5B, kinesin light-chain and syntaxin-1 PMID: 22404429
14. Sytaxin 1A may be involved in rearrangement of synaptic connections between neurons in the spinal dorsal horn induced by peripheral nerve injury. PMID: 21129445
15. Lack of STX1A could induce dysfunction of the HPA axis, and the deficit may result in abnormal behavioural properties, such as unusual responses to stress stimuli. PMID: 21910766
16. HPC-1/syntaxin 1A regulates catecholaminergic systems via exocytosis of dense-core synaptic vesicles. Deletion of HPC-1/syntaxin 1A causes impairment of long term potentiation induction. PMID: 22219298
17. Syntaxin-1A inhibits KATP channels by interacting with specific conserved motifs within sulfonylurea receptor 2A. PMID: 21884702
18. STX1A may play a role in the structural formation of the inner nuclear layer and outer plexiform layer in the retina. PMID: 21822613
19. granuphilin binds to syntaxin-2 and syntaxin-3 as well as syntaxin-1a, it likely mediates granule docking through interactions with those multiple syntaxins on the plasma membrane. PMID: 21768089
20. ATP regulates pancreatic beta-cell K(ATP) channel activity, not only by its direct actions on Kir6.2 pore subunit, but also via ATP modulation of Syn-1A binding to SUR1. PMID: 21173146
21. Data show that ablation of syntaxin 1A may cause disruption of 5-HT-ergic transmission and induce abnormal behavior. PMID: 20576034
22. syntaxin 1a has a role in granuphilin promotion of plasma membrane targeting of insulin granules PMID: 15028737
23. These data demonstrate that the Munc18-1 interaction with syntaxin 1 is physiologically important, but does not represent a classical chaperone-substrate relationship. PMID: 15935055
24. Our data indicate that htt(exon1) enhances calcium influx by blocking syntaxin 1A inhibition of N-type calcium channels and attributes a key role for htt N-terminal fragments in the fine tuning of neurotransmission. PMID: 16162412
25. These observations suggest that HPC-1/syntaxin 1A may be closely related to synaptic plasticity PMID: 16723534
26. the interaction of Sept5 with syntaxin-1 is regulated by the phosphorylation of Sept5_v1 at Ser17 by Cdk5-p35 PMID: 17224448
27. HPC-1/syntaxin 1A might play a role in synaptic plasticity in the nociceptive pathway. PMID: 17953616
28. Stx1a interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux. PMID: 18617632
29. syntaxin 1A is an important regulator of normal in utero development, but may not be essential for normal brain function later in life. PMID: 18713622
30. Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis.( PMID: 19129200

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KEGG: mmu:20907

STRING: 10090.ENSMUSP00000005509

UniGene: Mm.6225