Recombinant Mouse T-box transcription factor TBX2 (Tbx2)

1. TBX2 is expressed in RPE cells both in vivo and in vitro. Specific knockdown of TBX2 in the human RPE cell line ARPE-19 leads to an accumulation of cells at G1. PMID: 28910203
2. Tbx18 does not function redundantly with Tbx2 or Tbx20 in epicardial development. PMID: 27253890
3. Standard chromatin immunoprecipitation and reporter assays suggest that TBX2 represses Oca2 at least in part directly. Hence, the results suggest that TBX2 may act as a nexus linking cell proliferation and melanogenesis PMID: 26971330
4. Msx1 and Tbx2 antagonistically regulate Bmp4 expression during the bud-to-cap stage transition in tooth development. PMID: 23720046
5. We show that Tbx2 directly represses Grem1 in distal regions of the posterior limb mesenchyme allowing Bone morphogenetic protein (Bmp) signaling to abrogate Fgf4/9/17 expression in the overlying epithelium. PMID: 23633963
6. The identification of TBX2 as a target for PAX3 provides a key insight into how PAX3 may contribute to melanoma evolution. PMID: 23020925
7. Tbx2-mediated regulation of Cdkn1a and Cdkn1b represents a crucial node in the network integrating patterning information and cell cycle regulation that underlies growth, differentiation, and branching morphogenesis of this organ. PMID: 23341776
8. an unanticipated link between TBX2 deregulation in cancer and the acquisition of EMT and invasive features of epithelial tumor cells. PMID: 22844464
9. This study lays the foundation for investigation of functional requirements for Tbx2 subfamily genes in development of the mammalian reproductive system. PMID: 22223620
10. Tbx2 and Tbx3 trigger development of the endocardial cushions through a regulatory feed-forward loop with Bmp2, thus providing a mechanism for the co-localization and coordination of these important processes in heart development. PMID: 22130515
11. Tbx2 and Tbx3 are both expressed in the pancreatic mesenchyme throughout development PMID: 21867776
12. The Tbx2-Tgfbeta2 cascade is one of the key pathways involved in inducing the transposition of the great arteries phenotype. PMID: 22186728
13. Data show that myocardium-specific inactivation of T-box 2 (Tbx2) leads to the formation of fast-conducting accessory pathways, malformation of the annulus fibrosus, and ventricular preexcitation in mice. PMID: 21266775
14. This review presents a state of the art overview of the role and regulation of Tbx2 in early embryonic development and in cancer[review] PMID: 19960541
15. Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal thus suppressing myocardial chamber formation PMID: 12023302
16. T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers. PMID: 15042700
17. Tbx2 is an immediate-early gene target in retinoic acid-treated B16 murine melanoma cells. PMID: 15093729
18. down-regulates Cdkn's, but loss of function doesn't result in increased levels of p19(ARF), p16(INK4a), p15(INK4b) or p21 PMID: 15459098
19. Tbx2 directly represses Nmyc1 in outflow tract and atrioventricular canal of the developing heart, resulting in relatively low proliferation. PMID: 15843407
20. Tbx20 may ensure progression to a multi-chambered heart by repressing Tbx2 in the myocardial precursor cells of the linear heart tube destined to form the chambers PMID: 15901664
21. Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway. PMID: 16222716
22. Results are consistent with Tbx2 playing a role in cell cycle progression and organization of subnuclear compartments. PMID: 16730707
23. Inactivation of TBX2 using a dominant-negative TBX2 resulted in up-regulation of p19(ARF) in SAFB1 knockout mouse embryo fibroblasts. PMID: 16912158
24. Tbx2 expression is observed during somitogenesis beginning at E9.5, both in the posterior half of prospective somites and in a progressively restricted pattern in recently formed somites. PMID: 16958122
25. Hesr1 and Hesr2 play crucial roles in AV boundary formation through the suppression of Tbx2. PMID: 17259303
26. the ability of Tbx2 to repress the p21 gene is enhanced in response to a stress-induced senescence pathway, which leads to a better understanding of the regulation of the anti-senescence function of Tbx2. PMID: 18025091
27. Msx1 and Msx2 can function in concert with the TBX2/3 to suppress Cx43 and other working myocardial genes. PMID: 18285513
28. A comparison of the expression of Tbx2 and Tbx3 in the developing hypothalamic-pituitary axis. PMID: 18534921
29. Results show that depending on the level of pocket proteins, loss of adhesion induces G(1) and G(2) arrest, which could be alleviated by overexpression of the TBX2 oncogene. PMID: 18936168
30. Tbx2 temporally suppresses differentiation and proliferation of primary myocardial cells. A subset of these Tbx2Cre-marked cells switch off expression of Tbx2, which allows them to differentiate into chamber myocardium and to initiate proliferation. PMID: 19423846
31. Tbx20 within the OFT, indicating complex and region-specific transcriptional cross-regulation between the two T-box genes. PMID: 19563797
32. Tbx2 is required for proper optic cup formation and plays a critical early role in regulating regional retinal growth and the acquisition of shape during optic vesicle invagination PMID: 19576202
33. Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal. PMID: 19661464
34. Mice homozygous mutant for Tbx2 and mice double heterozygous for Tbx2 and Tbx3 exhibit a cleft palate phenotype arguing for an important contribution of Tbx2 and Tbx3 to palatogenesis PMID: 19769959
35. Tbx2, a central intermediary of Bmp-Smad signaling, has a central part in directing Has2 and Tgfbeta2 expression, facilitating endocardial cushions formation. PMID: 19846762

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KEGG: mmu:21385

STRING: 10090.ENSMUSP00000000095

UniGene: Mm.287052