Recombinant Mouse Thrombopoietin receptor (Mpl)

1. these results demonstrate that MPL P106L is a receptor with an incomplete defect in trafficking. PMID: 28034873
2. C-Mpl is expressed on osteoblasts and osteoclasts and is important in regulating skeletal homeostasis. PMID: 26375403
3. CALR mutants are sufficient to induce thrombocytosis through MPL activation. PMID: 26608331
4. Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants. PMID: 26668133
5. The interaction between Mpl and Atp5d was confirmed by the yeast two-hybrid system, mammalian two-hybrid assay, pull-down experiment, and co-immunoprecipitation study in vivo and in vitro. PMID: 24615392
6. Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL. PMID: 25995324
7. MERIT40 deficiency triggers hypersensitivity to Tpo stimulation and the stem cell phenotypes are abrogated on a background null for the Tpo receptor Mpl. PMID: 25636339
8. OTT1 regulates the alternative splicing of Mpl-TR, a truncated isoform of c-Mpl, which modulates Thrombopoietin-mediated signaling. PMID: 25468569
9. These studies show the importance of the c-Mpl membrane-distal cytokine receptor homology module to thrombopoietin-binding and suggest that mutations within this CRM that perturb TPO binding could give rise to Congenital Amegakaryocytic Thrombocytopenia. PMID: 24438083
10. Mpl expression on megakaryocytes and platelets is essential to prevent megakaryocytosis and myeloproliferation. PMID: 24711413
11. These experiments define a novel VEGF-miR-1-Mpl-P-selectin effector pathway in lung Th2 inflammation and herald the utility of miR-1 and Mpl as potential therapeutic targets for asthma. PMID: 24043765
12. Gene-corrected Mpl(-/-) cells had increased long-term repopulating potential, with a marked increase in lineage(-)Sca1(+)cKit(+) cells and early progenitor populations in reconstituted mice. PMID: 21289307
13. Data indicate that Mpl is an active player during the first steps of definitive hematopoiesis establishment through direct regulation of the expression of transcription factors or genes important for the self-renewal, proliferation and apoptosis of HSCs. PMID: 20711984
14. Data locate Mpl expression to neurons at different subdivisions of the spinal cord, rhombencephalon, midbrain and prosencephalon; besides neuronal cells Mpl protein is also expressed in Purkinje cells of the adult cerebellum. PMID: 20667107
15. study describes a link between Mpl receptor signaling and IKK and NF-kappaB activities in megakaryocytes PMID: 11967992
16. mpl-II isoform cloning, base sequence, and amino acid sequence - lacks a 60 amino acid region required for surface expression of the protein PMID: 11997107
17. Thrombopoietin mediates cell proliferation in cells expressing high levels of Mpl but only mediates survival without proliferation in cells expressing low levels of the receptor. PMID: 12006617
18. A 2-kb c-mpl promoter fragment is sufficient to direct expression to the megakaryocytic lineage and sites of embryonic hematopoiesis in transgenic mice. PMID: 12130527
19. receptor motifs involved in TPO-induced internalization of Mpl are identified; results suggest that Mpl translocation may be necessary for normal cellular proliferation and that a pool of intracellular Mpl can be rapidly recycled to the cell surface PMID: 12623841
20. c-Mpl(-/-) Kit(Wv/Wv) mice reveal nonredundant and synergistic effects of Tpo and steel factor on primitive hematopoietic cells. PMID: 15138166
21. c-Mpl truncated isoform with an essential C-terminal peptide is required for a proteolytic process PMID: 15210714
22. mpl-tpo signaling pathways are negatively modulated by lnk PMID: 15337790
23. studies suggest that c-Mpl does not control HSC numbers, as had been previously argued, but rather facilitates the early expansion of differentiating clones. PMID: 17347409
24. Dual role of Mpl in the generation and expansion of hematopoietic stem cells during establishment of definitive hematopoiesis. PMID: 17634189
25. Down-regulation of Mpl marks the transition to lymphoid-primed multipotent progenitors with gradual loss of granulocyte-monocyte potential PMID: 18218856
26. c-Myb/p300 transcriptional regulatory complex has an indispensable role in megakaryocyte development and suppresses thrombocytopenia in Mpl-/- mice PMID: 18684867
27. AML1 can regulate the c-mpl promoter both positively and negatively by changing the binding partner according to cell types PMID: 18687690
28. impaired TPO(thrombopoietin) homeostasis in the Mpl transgene-rescued mice produces elevated plasma TPO levels, which serves as an unchecked stimulus to drive the observed excessive megakaryocytopoiesis PMID: 18796624
29. the severe reduction of Mpl protein in platelets in Mpl-transgenic Mpl(-/-) mice shifts the equilibrium of this feedback loop, resulting in markedly elevated levels of megakaryocytes and platelets at steady state PMID: 18845793
30. Thrombocytopenia in HLB219 mice is caused by a recessive mutation in Mpl that abrogates mitogen-activated protein kinase-extracellular signal regulated kinase and janus kinase-signal transducers and activators of transcription signaling. PMID: 19059699

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KEGG: mmu:17480

STRING: 10090.ENSMUSP00000130167

UniGene: Mm.4864