Recombinant Mouse Toll-like receptor 11 (Tlr11), partial

1. mechanisms of interaction with flagellin and profilin PMID: 26859749
2. Data show that TLR11 expression is induced in astrocytes, neurons, and microglia in the immune response to T. gondii infection PMID: 24704432
3. TLR11 mediates innate immune function of male germ cells in response to T. gondii profilin and uropathogenic escherichia coli stimulations. PMID: 24403550
4. Biochemical experiments revealed that TLR11 and TLR12 directly bind to Toxoplasma gondii profilin and are capable of forming a heterodimer complex. PMID: 24078692
5. Selective elimination of neutrophils in TLR11-deficient mice infected with Toxoplasma gondii results in acute susceptibility similar to that observed in IFN-gamma-deficient mice. PMID: 23754402
6. a potentially important role for TLR11 in preventing murine intestinal infection and modulating antigen transportation in the gut and imply an important role for various TLRs in cooperation with tight control of pathogens penetrating into Peyer patches. PMID: 23135279
7. association with UNC93B1 and the intracellular localization of TLRs are not unique features of nucleic acid-sensing TLRs but is also essential for TLR11-dependent recognition of T. gondii profilin and for host protection against this parasite PMID: 21097503
8. Data demonstrate that transcription of the Tlr11 gene is regulated through epithelium-specific transcription factors and IRF-8. PMID: 19801549
9. displays a distinct pattern of expression in macrophages and liver, kidney, and bladder epithelial cells; mice lacking TLR11 are highly susceptible to infection of the kidneys by uropathogenic bacteria PMID: 15001781
10. Toxoplasma gondii profilin activates dendritic cells through TLR11 and is the first chemically defined ligand for this TLR; TLR11 is required in vivo for parasite-induced IL-12 production and optimal resistance to infection PMID: 15860593
11. The immunogenicity of Toxoplasma gondii profilin was entirely dependent on both TLR11 recognition and signaling through the adaptor myeloid differentiation factor 88 (MyD88). PMID: 17000122
12. TLR11-deficient mice develop an abnormal immunopathological response to Toxoplasma gondii, as the result of non-toll-like receptor dependent activation of interferon-gamma secretion by natural killer cells in response to the infection. PMID: 19050265
13. TLRs 11-13 are expressed in normal and parasite infected mouse brains. This suggests a role for them in central nervous system infections. PMID: 19077284

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KEGG: mmu:239081

STRING: 10090.ENSMUSP00000068906

UniGene: Mm.291512