Recombinant Mouse Toll-like receptor 3 (Tlr3), partial

1. Pregnant mice lacking TLR3 in both maternal systemic and placental cells were completely resistant to the hypertension, proteinuria, fetal demise, endothelial dysfunction, splenomegaly, and increases in pro-inflammatory immune cells induced by TLR3 activation. PMID: 30177045
2. results indicate that TLR3 is the primary molecule which modulates the activation and function of NK cells during the course of Schistosoma japonicum infection in C57BL/6 mice PMID: 30246036
3. This study demonstrates that the synergistic effect between TLR4 and TLR3 in macrophages is an important determinant in acute lung injury and, more importantly, that TLR3 up-regulation is dependent on TLR4-MyD88-NF-kappaB signaling. PMID: 28198368
4. Results provide evidence that TLR3 signaling contributes to the dengue virus-induced increase in microglial migration. PMID: 28273893
5. this study shows that Tlr3 in nasal CD103(+) dendritic cells is involved in immunoglobulin A production PMID: 28612840
6. these data suggest that TLR3 promotes the clearance of Cm during early and mid-stages of genital tract infection, and that loss of TLR3 is detrimental in the development hydrosalpinx. PMID: 29624589
7. TLR3 deficiency in Tlr3 KO mice suppressed the development of chronic contact hypersensitivity reactions, suggesting that TLR3 signaling may participate in the pathogenesis of atopic dermatitis. PMID: 28807557
8. PolyI:C targeted Toll-like receptor 3 with minimal effect on the mitochondrial antiviral-signaling protein pathway. PMID: 29465830
9. determined whether the depletion of TLR3 modulated hepatic injury in mice and further aimed to provide mechanistic insights into the TLR3-mediated modulation of diet-induced hepatic inflammation and fat accumulation. PMID: 29410095
10. TLR3 signaling contributes to Wallerian degeneration after peripheral nerve injury by affecting Schwann cell activation. PMID: 27771719
11. the JAK-STAT pathway provides a cytokine rheostat mechanism, which enables macrophages to fine-tune their responses to multiple, temporally separated infection events involving the TLR3 and TLR7 pathways. PMID: 27405980
12. These results suggest that testicular innate immune responses to pathogens caused by nano-TiO2 may be involved in the regulatory mechanisms of TAM/TLR3 signaling in testicular Sertoli cells. PMID: 27643721
13. findings report that RKIP preferentially regulates the TLR3-mediated immune response in macrophages; phosphorylation of RKIP serine 109 is required for RKIP to promote TLR3-mediated signaling and inflammation PMID: 28411188
14. Furthermore, Leishmania RNA virus 1-induced TLR-3 activation promoted parasite persistence by enhancing macrophage survival through Akt activation in a manner partially dependent on miR-155. PMID: 27593513
15. Primary tumor-derived exosomal RNAs, which are enriched in small nuclear RNAs, activate TLR3 in lung epithelial cells, consequently inducing chemokine secretion in the lung and promoting neutrophil recruitment. PMID: 27505671
16. Autophagy contributes to macrophage resistance to Leishmania major. Data, including data from studies in knockout mice, suggest a key resistance mechanism involves endosomal signaling via Tlr3/7/9 in macrophages; macrophages deficient for Tlr3/7/9, Unc93b1, or MyD88 fail to undergo L. major-induced autophagy. (TLR = Toll-like receptor; Unc93b1 = unc-93 homolog B1; MyD88 = myeloid differentiation primary response gene 88) PMID: 28607148
17. Our study reveals a novel mechanism of TLR3 in regulation of dendritic morphology and provides an explanation for how environmental factors influence mental health. PMID: 27979975
18. results reveal a novel CD40-dependent regulation of PD-L1 trafficking induced upon TLR3 signaling that dictates its inhibitory activity. PMID: 27911948
19. This study reveals novel insights into the pathophysiology of epilepsy and the contribution of TLR3 to disease progression. PMID: 28166388
20. This study suggests that deliberate control of TLR signaling is a key factor in the success of mRNA-driven cellular reprogramming. PMID: 27586271
21. the activation of TLR3 promotes the loss of RGCs and their axons by elevating Rtca levels in the retina. Also, the results presented in this study show that Rtca regulates JNK3 expression in the retina. PMID: 27727398
22. identify iNOS/NO as an integral component of IFN-beta production in response to dsRNA in hepatocytes in a pathway that involves the coordinated activities of TLR3/Trif and PKR PMID: 27226571
23. we found that Aire up-regulated TLR3 expression and modulated the downstream cytokine expression and nuclear factor-kappaB (NF-kappaB) of the TLR3 signaling pathway. PMID: 27916941
24. synergy of TLR3 and 7 ligands could significantly enhance the function of DCs to present inactivated PRRSV antigen through TRIF/MyD88-NF-kappaB signaling pathway and be used as adjuvant candidate for the development of novel PRRS inactivated vaccine PMID: 27046485
25. Our findings support a potential regulatory role of TLR3 in alcohol consumption. PMID: 26885867
26. The results imply that recognition of resident viruses by TLR3 and TLR7 is required for protective immunity during gut inflammation. PMID: 27084119
27. TRIF-independent pathways can be involved in the downregulation of drug metabolizing enzymes and transporters through TLR4 and 3. JNK-dependent mechanisms likely mediate this downregulation. PMID: 26470915
28. during Respiratory syncytial virus infection, respiratory macrophages and dendritic cells mediate the production of IL-33 in a TLR-dependent manner PMID: 26603638
29. TNFalpha-blockade stabilizes local airway hyperresponsiveness during TLR3/4-induced exacerbations in murine model of asthma. PMID: 26494305
30. Shock wave treatment protects from neuronal degeneration via TLR3 signaling and subsequent TLR4 downregulation in model of ischemic spinal cord injury. PMID: 26508745
31. The authors confirmed that the protective effect of poly I:C against enteric infection of mice with Yersinia enterocolitica was dependent on TLR3-mediated TRIF signaling by using TLR3-deficient mice. PMID: 26793623
32. The results of the present study indicate that activation of TLR3 by PolyI:C induces the spermatogonial stem cells apoptosis, which implies that viral infection may interfere with the male germ cell development. PMID: 26350376
33. dsRNA and TLR3 link the earliest events of mammalian skin wounding to regeneration and suggest potential therapeutic approaches for promoting hair neogenesis. PMID: 26253200
34. Data indicate that calgranulin B (S100A9) is essential for in vivo toll like receptor 3 (TLR3) signaling. PMID: 26385519
35. Data show that tripartite motif-containing 38 protein (Trim38) deficiency potentiates toll like receptors TLR3/4-mediated signaling in primary immune cells. PMID: 26392463
36. A comparison of TLR3-and TLR4-stimulated genes. PMID: 26159724
37. TLR3 that recognizes viral RNA depends on interferon alpha/beta receptor signaling to induce DC maturation. PMID: 26508631
38. These results increase the understanding of the function of innate receptors in metabolic disorders and implicate TLR3 as a key control system in metabolic regulation. PMID: 25918231
39. Expression level of TLR3 was upregulated and the phosphorylation level of IRF3 in the nucleus was enhanced in herpes simplex virus type-1-infected mouse neural stem cells. PMID: 25633775
40. mechanism conversely holds for plasmacytoid DCs that respond to TLR3 ligation when TLR7 pathway is mobilized. PMID: 26255864
41. TLR3-activation establishes a type I IFN-dependent antiviral program in a dendritic cell subtype playing crucial roles in priming adaptive antiviral immune responses. PMID: 26101320
42. TLR9 modulates TLR3 expression in Leishmania major-infected macrophages. PMID: 25911242
43. TLR3 mediated antibody response to Chikungunya virus infection, virus replication and pathology. PMID: 25452586
44. the ncRNA U1 acts in a TLR3-dependent manner to induce expression of skin barrier repair genes PMID: 25118157
45. critical for coxsackievirus B4-induced type 1 diabetes PMID: 25422874
46. results show that TLR3 enhances antigen-independent skin inflammation in the elicitation phase of allergic contact dermatitis PMID: 25229251
47. Cell surface TLR3 was highly expressed on splenic CD8+ dendritic cells and marginal zone B cells. PMID: 25305318
48. Ischemic preconditioning-induced ischemic tolerance is mediated by astrocytic TLR3 signaling. PMID: 24914679
49. TLR-3 seems to participate in the pathogenesis of early acute kidney injury PMID: 24736450
50. EP3 and TLR3 in conjunctival epithelium play a critical role in regulating ocular surface inflammation. PMID: 24036040

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KEGG: mmu:142980

STRING: 10090.ENSMUSP00000034056

UniGene: Mm.33874