Product Details

Purity

>85% (SDS-PAGE)

Target Names

Tlr6

Uniprot No.

Q9EPW9

Alternative Names

Tlr6; Toll-like receptor 6; EC 3.2.2.6; CD antigen CD286

Species

Mus musculus (Mouse)

Protein Length

Partial

Tag Info

Tag type will be determined during the manufacturing process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer before Lyophilization

Tris/PBS-based buffer, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet

Please contact us to get it.

Target Background

Function

Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides. In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

Gene References into Functions

findings show that TLR6 and mannose receptor participate as macrophage receptors for Mycobacterium lepraemurium PMID: 28317806
the cooperative role of TLR9 with TLR2 or TLR6 receptors in sensing Brucella, was determined. PMID: 26578650
TLR6 knockout alleviates generation of myocardial fibrosis by suppressing collagen deposition. PMID: 26940740
Dengue virus NS1 protein is the viral protein responsible for the activation of TLR2 and TLR6 during Dengue virus infection PMID: 26226614
Hepatic expression of Tlr6, but not that of Tlr8 is epigenetically controlled, and that the dysregulations of Tlr6 and Tlr8 critically contribute to Testosterone (T)-induced persistent susceptibility to P. chabaudi malaria. PMID: 25056943
Transmembrane oligomeric form of Vibrio cholerae cytolysin (VCC) triggers TLR2/TLR6-dependent proinflammatory responses in monocytes and macrophages. PMID: 25431887
The inhibition of TLR receptors 2 and 6 in the presence of their specific ligands restored the ability of the spheroids to bind to the endometrial cells. PMID: 24621922
The results demonstrate that inflammatory responses caused by ZNPs-activated macrophages strongly depend on TLR6-mediated MAPK signalling. PMID: 24593842
TLR6 on bone marrow dendritic cells can sense Mycobacterium avium and this receptor is required for full resistance to M. avium infections. PMID: 23716075
The toll-like receptor 2/6 agonist MALP-2 promotes reendothelialization and inhibits neointima formation after experimental vascular injury via enhanced proliferation and migration of endothelial cells. PMID: 23868938
In this study, we report that transmembrane domain (TMD)-derived peptides from TLR2 and TLR6 specifically inhibit TLR2 activation PMID: 23677476
the results presented here indicate that TLR6 is required to trigger innate immune responses against B. abortus in vivo and is required for the full activation of dendritic cells to induce robust proinflammatory cytokine production. PMID: 23460520
TLR6 activation is critical for IL-23 production and Th17 responses, which both regulate the allergic inflammatory response in chronic fungal-induced asthma. PMID: 22005301
Although targeted deletion of TLR6 does not affect the incidence or severity of myelin oligodendrocyte glycoprotein (MOG)35-55 peptide-induced autoimmune encephalomyelitis, signaling via MyD88 is necessary. PMID: 21685327
data demonstrate the requirement for TLRs in inducible resistance against pneumonia and reveal a remarkable, unanticipated synergistic interaction of TLR2/6 and TLR9 PMID: 21482737
TLR6 plays a pivotal role in the development and severity of hypersensitivity pneumonitis via its role in IL-17A production. PMID: 20070409
TLR2 and TLR6 deletions affected lipid droplet formation in bacterium-bearing cells only partially, suggesting the involvement of alternative receptors of the innate immune response besides TLR2/6 for Mycobacterium leprae recognition by macrophages. PMID: 19952355
Differential recognition of structural details of bacterial lipopeptides by toll-like receptors 2 and 6. PMID: 12432564
TLR6 KO mice were not different from wild-type mice in terms of pulmonary tuberculosis histopathology, mRNA expression and CFU assay PMID: 12825894
Porin of Shigella dysenteriae type 1 increased the mRNA levels for TLR2 and TLR6 of peritoneal cavity cells, implicating that coexpression of TLR2 and TLR6 is essential as a combinatorial repertoire for recognition of porin by the B-1 cells PMID: 15482852
decreased mRNA expression during Salmonella enterica serovar Typhimurium sublethal infection PMID: 15731092
Recognition of C. albicans by TLR6 modulated the balance between Th1 and Th2 cytokines, and TLR6 knock-out mice displayed a defective production of IL-10 and an increased IFN-gamma release. PMID: 18036178
Toll-like receptors 2 and 6 signaling from the phagosome is enhanced by mannose-binding lectin PMID: 18180310
TLR6 may be a key factor in determining whether the response to PDG would be apoptosis or inflammation. PMID: 18424724
The authors show that TLR6 associates with TLR2 to induce tolerogenic DC and regulatory type-1 T cells selectively secreting IL-10. PMID: 18854239
Mice deficient in TLR6 are susceptible to experimental autoimmune encephalomyelitis PMID: 19211042
Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis PMID: 19458089
Analyses of the cytokine production profile of macrophages isolated from knockout mice deficient in TLRs or in MyD88 and TRIF revealed a critical role for TLR2, TLR6 and MyD88 in the production of IFNbeta-independent chemokines. PMID: 19543380

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Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein. Membrane raft. Golgi apparatus.

Protein Families

Toll-like receptor family

Tissue Specificity

Detected in thymus, spleen, ovary and lung. Expressed in macrohpages.

Database Links

KEGG: mmu:21899

STRING: 10090.ENSMUSP00000062096

UniGene: Mm.42146

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Code	CSB-YP023605MO
MSDS	MSDS
Size	Pls inquire
Source	Yeast
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Code	CSB-EP023605MO
MSDS	MSDS
Size	Pls inquire
Source	E.coli
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Code	CSB-EP023605MO-B
MSDS	MSDS
Size	Pls inquire
Source	E.coli
Conjugate	Avi-tag Biotinylated E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code	CSB-BP023605MO
MSDS	MSDS
Size	Pls inquire
Source	Baculovirus
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Code	CSB-MP023605MO
MSDS	MSDS
Size	Pls inquire
Source	Mammalian cell
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Recombinant Mouse Toll-like receptor 6 (Tlr6), partial

Product Details

Customer Reviews and Q&A

Target Background

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