Recombinant Mouse Transcription factor 12 (Tcf12)

1. Study results place HEB at the top of the known gene network that regulates gammadeltaT17 cell programming. PMID: 29222418
2. Tcf12 is a transcription factor highly expressed in the nuclei of stem cells and its downregulation plays an essential role in osteoblast differentiation. PMID: 27574032
3. we identified transcription factor TCF12 as a new target of miR-211 in oral squamous cell carcinoma PMID: 27221705
4. HEB is a fundamental link between Nodal signalling, the derepression of a specific class of poised promoters during differentiation, and lineage specification in mouse embryonic stem cells PMID: 25775035
5. severe bilateral coronal synostosis occurs in mice with 50% of the wild-type dosage of both the Tcf12 and Twist1 genes highlights the key role of TCF12 acting with TWIST1 in the normal development of the coronal sutures PMID: 23354436
6. Deficiency in the E proteins, E2A and HEB, led to increased frequency of terminally differentiated effector KLRG1(hi) CD8(+) T cells in mice during infection, and decreased generation of longer-lived memory-precursor cells during the immune response. PMID: 22585759
7. Deletion of HEB and E2A in DP thymocytes specifically blocked the development of CD4(+) lineage T cells. Furthermore, deletion of the E protein inhibitors Id2 and Id3 allowed CD4(+) T cell development but blocked CD8(+) lineage development. PMID: 22425249
8. the earliest event in B-cell specification involves the induction of FOXO1 expression and requires the combined activities of E2A and HEB PMID: 21972416
9. These results showed a new set of interactions between HEB, Notch1, and GATA3 that regulate the T-cell fate choice in developing thymocytes. PMID: 21189289
10. HEBAlt enforces T-lineage cell development during hematopoiesis.One role of HEBAlt may be to suppress myeloid development in developing T-cell precursors. PMID: 21115673
11. Developmental progression of fetal HEB(-/-) precursors to the pre-T-cell stage is restored by HEBAlt. PMID: 21061441
12. HEBAlt can suppress B cell or myeloid potential in a context-specific manner, which suggests a role for this factor in maintaining T lineage priming prior to commitment. PMID: 20826759
13. HEB is a specific and essential factor in T-cell development and in the generation of the iNKT cell lineage. PMID: 20154672
14. the dosage of HEB determines pT alpha gene expression in immature T cells PMID: 12566462
15. the Tcf12 gene may be involved in the control of proliferating neural stem cells and progenitor cells PMID: 15018808
16. repression of E47/HEB by tal1/scl induces leukemia PMID: 15193261
17. dHAND/E-protein (E2A, ME2, and ALF1) heterodimers have distinct DNA binding specificities PMID: 15351717
18. A new transcription factor HEBAlt is specifically required for the efficient generation of early T lymphocyte precursors. PMID: 16785505
19. Data show that upon induction of differentiation, a MyoD-HEB beta complex binds to the E1 E-box of the myogenin promoter, leading to transcriptional activation. PMID: 16847330
20. ME1 mRNA is first detected in the jejunum and ileum two weeks after birth when the number of Paneth cells starts to increase. PMID: 17405739
21. These results suggest that E2A and HEB are not only critical for T cell differentiation but also necessary to retain developing thymocytes in cell cycle arrest before pre-TCR expression. PMID: 17442955
22. HEB and E2A as the gatekeepers that maintain cells at the DP stage of development until a functional alphabetaTCR is produced. PMID: 18093538
23. The expression of E2-2, E2A, HEB as well as Id mRNA during T cell development, was analyzed. PMID: 18384878
24. key residues in AML1-ETO for HEB association were mutated and these mutations do not impair the ability of AML1-ETO to enhance the clonogenic capacity of primary mouse bone marrow cells PMID: 19204326

Show More

Hide All

KEGG: mmu:21406

STRING: 10090.ENSMUSP00000034755

UniGene: Mm.171615