Recombinant Mouse Transcription factor 7-like 2 (Tcf7l2)

1. This work identified Tcf7L2 as the principal transcription factor mediating canonical Wnt signalling in the embryonic neocortex. PMID: 29751817
2. TCF7L2 protein is increased during adipogenesis in 3T3-L1 cells and primary adipocyte stem cells and that TCF7L2 expression is required for the regulation of Wnt signaling during adipogenesis. PMID: 29317436
3. Data (including data from studies in transgenic mice) suggest that inactivation of Tcf7l2 in pancreatic pericytes is associated with impaired expression of genes required for pancreatic beta-cell function and maturity of isolated pancreatic islets. Transgenic mice in which Tcf7l2 is selectively inactivated in pancreatic pericytes exhibit glucose intolerance. PMID: 29246974
4. TCF7L2 does not affect oligodendrocyte precursor cells during remyelination. PMID: 28656232
5. Findings demonstrate an alpha cell-autonomous role for Tcf7l2 in the control of pancreatic glucagon secretion and the maintenance of alpha cell mass and function. PMID: 28343277
6. Suggest transcription factor 7-like 2 is a possible regulator of glucagon-like peptide 1 receptor expression in endothelial/smooth muscle cells in diabetic mice. PMID: 28830217
7. along with the elevation of miR-17-5p expression in mouse epididymal fat tissue in response to high fat diet consumption, allowed us to suggest that miR-17-5p is among central switches of adipogenic differentiation PMID: 28102847
8. TCF7L2 mediates canonic Wnt/beta-catenin signaling and c-Myc upregulation during abnormal cardiac remodeling in heart failure and suppression of Wnt/beta-catenin to c-Myc axis can be explored for preventing and treating heart failure. PMID: 27301468
9. These findings suggest a unique role for Tcf7l2 in generating distinct neuronal phenotypes from homogeneous progenitor population. PMID: 28219675
10. Tcf7l2 may be involved in maintenance of stem/progenitor cells properties. PMID: 27281479
11. results indicate that miR-181a-5p promotes 3T3-L1 preadipocyte differentiation and adipogenesis through regulating TGFbeta/Smad and Wnt signaling pathway by directly targeting Smad7 and Tcf7l2 PMID: 27742678
12. Tcf7l2 protein levels decline upon initiation of endocrine differentiation in vivo, disclosing the downregulation of this factor in the developing endocrine compartment. PMID: 26771085
13. Tcf7l2 plays a cell autonomous role in the control of beta cell function and mass, serving as an important regulator of gene expression and islet cell coordination PMID: 25355422
14. Tcf7l2 is regulating proinsulin expression directly via Isl1, Ins1 and indirectly via MafA, NeuroD1 and Pdx1. PMID: 25015099
15. Transcription factor 7-like 2 positively regulates neonatal and postnatal mouse oligodendrocyte differentiation during developmental myelination and remyelination in a manner independent of the Wnt/beta-catenin signaling pathway. PMID: 25810530
16. TCF7L2 expressed in the pancreatic beta cells plays a crucial role in glucose metabolism through regulation of the beta cell mass. PMID: 24317852
17. Marked expression of TCF7L2 in oligodendrocytes is restricted to a well defined time period during developmental myelination in human and mouse central nervous system tissue samples. PMID: 23977356
18. 5-FU acutely induces the severe myelin degeneration in adolescence and disruption of TCF7L2/HDAC1/HDAC2 complex is at least partially involved in 5-FU-induced demyelination. PMID: 25178657
19. Knockdown of TCF7L2 blocked the malondialdehyde-induced glucose-stimulated insulin secretion elevation. PMID: 24035868
20. This is the first report to show that DIF-1 inhibits tumor growth in vivo, consistent with its in-vitro action, suggesting that this compound may have potential as a novel anti-tumor agent. PMID: 24670930
21. The dominant-negative isoforms of TCF7L2 are predominant in the embryonic thalamus but disappear postnatally. PMID: 23152144
22. an essential role for Tcf4 during homeostasis of the adult mouse intestine PMID: 22393260
23. Data suggest that TCF7L2 and Wnt signaling control gut and brain proglucagon expression and glucose homeostasis; positive cross-talk between Wnt and glucagon-like peptide 1/cAMP signaling appears to regulate brain metabolism. PMID: 22966074
24. robust TCF7L2 expression was found in the tectal and tegmental structures of the superior and inferior colliculi as well as transient expression in neuroepithelium of the cerebral and hippocampal cortices of E16 and E18.5[review] PMID: 22796301
25. Selective deletion of Tcf7l2 in the pancreas alters glucose homeostasis in mice carrying TCF7L2 risk alleles, indicating the direct role of this factor in controlling beta cell function. PMID: 22717537
26. A mouse genetics approach shows that removal of TCF4 from beta cells does not affect their function, whereas manipulating TCF4 levels in the liver has major effects on metabolism. In Tcf7l2 double negatice mice, the immediate postnatal surge in liver metabolism does not occur. Consequently, pups die due to hypoglycemia. PMID: 23260145
27. Data suggest that TCF7L2 and Wnt signaling are negative regulators of gluconeogenesis in hepatocytes; TCF7L2 is among the downstream effectors of insulin in hepatocytes; insulin or feeding stimulates hepatic TCF7L2 expression. PMID: 22967502
28. these data suggest a crucial role of TCF7L2 in hepatic glucose metabolism; reduced hepatic expression of nuclear isoforms of this factor might be a critical instigator of hyperglycemia in type 2 diabetes PMID: 23028378
29. During myelin formation, Tcf7l2/beta-catenin is regulated temporally, spatially, and also at levels of expression. PMID: 22160878
30. The results suggest that decreased expression of Tcf7l2 confers reduction of diabetic susceptibility in mice via regulation on the metabolism of glucose and lipid. PMID: 22719219
31. Tcf7l2 alters behavior in mice. Importantly, these differences are observed prior to the onset of detectable glucose metabolism abnormalities PMID: 22046400
32. Tcf7l2 plays a role in regulating glucose tolerance, suggesting that overexpression of this gene is associated with increased risk of T2D. PMID: 21673050
33. T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis. PMID: 21383188
34. regulates activin receptor-like kinase 1 (ALK1)/Smad1 pathway for development of diabetic nephropathy PMID: 20803090
35. Wnt/beta-catenin/TCF7L2 pathway is preferentially able to alter the transcriptional regulation of the TGF-beta-target gene, TMEPAI. PMID: 20889500
36. A minimal promoter for intestinal cell kinase contains functional sites for beta-catenin/TCF7L2 and FOXA. PMID: 20459822
37. Tcf7l2 is a type 2 diabetes susceptbility gene, and may also regulate obesity. PMID: 19898815
38. the cell-type-specific complement of TCF4 isoforms is likely to be a major determinant for the context-dependent transcriptional output of Wnt/beta-catenin signalling. PMID: 20044351
39. Collectively, these patterns of expression suggest that TCF7L2 has distinct functions within the brain, with a general role in the development and maintenance of thalamic and midbrain neurons, and then a distinct role in autonomic homeostasis. PMID: 19845015
40. Tcf4 and Aes influence pituitary growth and development, and place Tcf4 and Tle3 in the genetic hierarchy with Pro PMID: 12907761
41. Smad1, beta-catenin and Tcf4 have roles in controlling Myc transcription PMID: 15576399
42. association of beta-catenin with androgen receptor and T-cell factor 4 (TCF4) in the presence of androgens PMID: 16210377
43. The results of these studies provide evidence of a mechanistic link between the Wnt/TCF4 and the Msx1/Pax3/MyoD pathways within limb bud muscle precursor cells. PMID: 17727834
44. Data suggest that TCF4 is necessary both intrinsically and extrinsically to Rathke's pouch to ensure the proper growth of the pituitary gland. PMID: 17919533
45. Depletion of endogenous progastrin inhibits the tumorigenicity of APC-mutated colorectal cancer cells in vivo by promoting ICAT expression, thereby counteracting beta-catenin/Tcf-4 activity. PMID: 17920061
46. Reduced TCF7L2 expression reduces glucose-simulated insulin secretion and insulin gene expression while slightly potentiating glucose stimulated changes in intracellular free Ca(2+) concentrations. PMID: 18481957
47. study mapped developmental expression of Tcf7l2 in developing cerebellum; consensus emerging our data is that expression of Tcf7l2 isoforms comprising or lacking C-clamp motif is tightly correlated with the proliferative status in vivo PMID: 19125404
48. While TCF7L2 mRNA levels were increased in isolated islets from the diabetic mouse, protein levels were decreased. PMID: 19386626
49. SDF-1 promotes pancreatic beta cell survival via the stabilisation and activation of beta-catenin/TCF7L2 transcriptional activators. PMID: 19468708
50. findings show that crosstalk between HDAC1/2 and the canonical Wnt signaling pathway mediated by TCF7L2 serves as a regulatory mechanism for oligodendrocyte differentiation PMID: 19503085

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KEGG: mmu:21416

STRING: 10090.ENSMUSP00000107284

UniGene: Mm.139815