Transcription factor 7-like 2 is a protein in humans that is encoded by TCF7L2 gene. Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
The following TCF7L2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
TCF7L2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA023307GA01HU | TCF7L2 Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA889079ZA01HU | TCF7L2 Antibody |
Homo sapiens | ELISA, WB (ensure identification of antigen) |
TCF7L2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP846068MO CSB-EP846068MO CSB-BP846068MO CSB-MP846068MO CSB-EP846068MO-B |
Recombinant Mouse Transcription factor 7-like 2 (Tcf7l2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
TCF7L2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP889079HU CSB-BP889079HU CSB-MP889079HU CSB-EP889079HU-B |
Recombinant Human Transcription factor 7-like 2 (TCF7L2), partial |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP889079HU | Recombinant Human Transcription factor 7-like 2 (TCF7L2), partial |
E.coli |