Recombinant Mouse Transcription factor E2F2 (E2f2)

1. Genomic structure, expression pattern, and functional characterization of transcription factor E2F-2 from black tiger PMID: 28558060
2. Findings implicate E2F-2 in regulating the expression of mitotic kinases that are adapted to perform specialized functions in nuclear condensation and enucleation of maturing erythroblasts. PMID: 27795297
3. Spinal cord injury-induced activation of E2F1-2 mediates cell cycle activation, contributing to gliopathy and neuronal/tissue loss associated with motor impairments and post-traumatic hyperesthesia. PMID: 26505089
4. E2F2 loss results in increased lung metastasis in breast cancer, potentially functioning through a PTPRD dependent mechanism. PMID: 26474282
5. A role for E2F1 and E2F2 as suppressors of replicative stress in differentiating cells, and the existence of a robust E2F-p53 regulatory axis in tissue homeostasis enabling and tumorigenesis preventing is shown. PMID: 25656653
6. E2F2 accumulates at sites of oxidative and UV-induced DNA damage, and interact with gammaH2AX DNA repair factor. PMID: 25892555
7. E2F2 activity sustains the hepatic homeostasis of major membrane glycerolipid components while it is dispensable for storage glycerolipid balance. PMID: 25396754
8. Rb-deficient cells hijack and redeploy Myc and E2f3 from an S-G2 program essential for normal cell cycles to a G1-S program that re-engages ectopic cell cycles, exposing an unanticipated addiction of Rb-null cells on Myc. PMID: 26192440
9. showed that the D326V missense pRb bound to E2F1 but failed to interact with E2F2/3 PMID: 25088905
10. E2F3 promotes while E2F2 suppresses ischemic cardiac repair through corresponding changes in endothelial cell proliferation. PMID: 23799044
11. E2F2 impairs, and endothelial E2F3 promotes, the angiogenic response to peripheral ischemic injury through corresponding changes in EC cell-cycle progression. PMID: 23603666
12. E2f2 induces cone photoreceptor apoptosis independent of E2f1 and E2f3 in mice. PMID: 23558950
13. these results indicate that the transcriptional activity of E2F2 contributes to promote adult hepatocyte proliferation and liver regeneration. PMID: 21527726
14. E2F1-3 in mediating transcriptional repression by retinoblastoma tumor suppressor during cell cycle exit and point to a critical role for their repressive functions in cell survival. PMID: 21185283
15. functions for E2f1-3 at distinct stages of myeloid development in vivo, first as repressors in cell survival and then as activators in cell proliferation. PMID: 21115501
16. loss of E2F2 results in a deregulated Aryl-hydrocarbon-receptor pathway PMID: 20573986
17. Findings show that rapid proliferation of E2F1/E2F2 compound mutant cultures is temporally followed by induction of a DNA damage response and the implementation of a p21(CIP1)-dependent senescence. PMID: 20676136
18. Control of miRNAs by E2F is likely to play multiple roles in cell proliferation and in proliferative diseases such as cancer. PMID: 20404092
19. we have examined the effect that a simultaneous inactivation of the E2F2 gene and over-expression of the Bcl-2 gene in B cells has on lymphoid homeostasis and autoimmunity PMID: 20187704
20. findings demonstrate that E2F2 can function as a tumor suppressor in epithelial tissues, perhaps by limiting proliferation in response to Myc PMID: 19798698
21. loss of activating E2fs caused downregulation of the p53 deacetylase Sirt1, p53 hyperacetylation and elevated apoptosis, establishing a novel E2f-Sirt1-p53 survival axis in vivo PMID: 20016601
22. In differentiating cells E2f1-3 function in a complex with Rb as repressors to silence E2f targets and facilitate exit from the cell cycle PMID: 20016602
23. E2F1 and E2F2 play essential and redundant roles in the proper coordination of cell cycle progression with differentiation which is necessary for efficient hematopoiesis PMID: 12724419
24. role in postnatal pancreas development and homeostatic maintenance PMID: 14566047
25. E2F2 promotes unscheduled cell division and oncogenic transformation of thymic epithelial cells PMID: 14684733
26. E2F1/E2F2 compound-mutant mice develop nonautoimmune insulin-deficient diabetes and exocrine pancreatic dysfunction PMID: 15146237
27. A role is indicated for E2F2 in promoting T cell proliferation in response to T cell receptor (TCR) stimuli in the context of homeostatic signaling in vivo. PMID: 16002659
28. the negative regulation of the p53-p21(CIP1) axis by the E2F1-3 factors is critical for cell cycle progression and cellular transformation PMID: 17008321
29. a critical function of the E2F1, E2F2, and E2F3 activators is in the control of a p53-dependent axis that indirectly regulates E2F-mediated transcriptional repression and cellular proliferation PMID: 17167174
30. T-antigen-induced intestinal proliferation is reduced in mice lacking either E2F2 alone or both E2F2 and E2F3a PMID: 17855529
31. E2F2 has a tumor suppressor function in Myc-induced T cell lymphomagenesis PMID: 17881568
32. These results implicate deregulated E2f-2 in the cell cycle defects observed in Rb null erythroblasts and reveal a novel role for E2f-2 during terminal red blood cell differentiation. PMID: 17923680
33. E2F4 is important in early stages of commitment to the lymphoid lineage. PMID: 18322175
34. Results suggest a model in which Erythroid Kruppel-like factor-dependent activation and modification of the E2f2 locus is required for cell cycle progression preceding terminal erythroid differentiation. PMID: 18852285
35. E2F2 Transcription Factor functions to transcriptionally repress cell cycle genes to establish the G(0) state. PMID: 19066456
36. E2F2 and E2F3 had positive effects on the promoter activity of fibrillin-2 in chondrocyte differentiation PMID: 19142862
37. Direct regulation of the E2f2 enhancer is a generic mechanism by which many Kruppel-like factors regulate proliferation and differentiation. PMID: 19457859
38. GATA-1, the master transcription factor of erythropoiesis, forms a tricomplex with the retinoblastoma protein (pRb) and E2F-2. PMID: 19513100
39. The absence of E2F2 substantially accelerates Myc-induced lymphomagenesis. PMID: 19749980
40. results identify a cell-cycle-independent mechanism by which E2F2 regulates endothelial function, arterial contractility, and blood pressure PMID: 19752322
41. The E2F1-3 transcription factors are essential for cellular proliferation PMID: 11719808
42. E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis PMID: 11713289
43. Mutation of E2F2 in mice causes enhanced T lymphocyte proliferation, leading to the development of autoimmunity PMID: 11754817

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KEGG: mmu:242705

STRING: 10090.ENSMUSP00000050047

UniGene: Mm.307932