Recombinant Mouse Transcription factor E2F4 (E2f4)

1. E2f4 forms apical cytoplasmic organizing centres for assembly and nucleation of deuterosomes. Using genetically altered mice and E2F4 mutant proteins we demonstrate that centriole amplification is crucially dependent on these organizing centres and that, without cytoplasmic E2f4, deuterosomes are not assembled, halting multiciliogenesis PMID: 28675157
2. E2f4 and E2f5 display overlapping roles in controlling the normal development of the male reproductive system. PMID: 26825228
3. Following stress exposure, E2F4-p130 complexes are lost rapidly along with the presence of E2F4 at E2F-containing B-Myb promoter sites. PMID: 24828495
4. E2F4 is part of a transcriptional repressor complex comprising p130 and HDAC1 in cardiac myocytes. Relief from E2F4-dependent gene silencing induces the expression of pro-apoptotic genes. PMID: 22985930
5. In terminally differentiated cells, common KDM5A and E2F4 gene targets were bound by the pRB-related protein p130, a DREAM complex component. PMID: 23093672
6. We report here a new cellular function of p27 as a transcriptional regulator in association with p130/E2F4 complexes that could be relevant for tumorigenesis. PMID: 22179826
7. Induction of Wnt/beta-catenin signaling in mouse mesenchymal stem cells is associated with activation of the p130 and E2f4 and formation of the p130/Gsk3beta/beta-catenin complex. PMID: 21631154
8. E2F4 plays an important role in enabling osteoblast progenitors to exit the cell cycle and subsequently differentiate thereby contributing to the commitment of these cells to the bone lineage. PMID: 20581455
9. Our data indicate that E2F4 is required for cardiomyocyte proliferation and suggest a function for E2F4 in mitosis PMID: 19955219
10. E2F4 controls cell cycle exit through different mechanisms. PMID: 20023434
11. interactions are regulated by G1 cyclin/cyclin-dependent kinase-coordinated phosphorylation of endogenous pocket proteins PMID: 12401786
12. E2F4 has a role in adipogenesis independent of its cell cycle regulatory activity PMID: 12604789
13. E2F3a and E2F4, but not E2F5, function to induce cell cycle entry, although E2F4 has more modest activity. E2F3a may induce cell death primarily through activation of p73alpha. PMID: 15855772
14. macrocytic anemia of E2f4(-/-) mice results primarily from impaired cellular proliferation and that the major role of E2f4 in fetal erythropoiesis is to promote cell cycle progression and cellular proliferation. PMID: 16861343
15. Required to determine the appropriate development of the airway epithelium. PMID: 17383628
16. This study investigated if the distribution between nucleus and cytoplasm of the transcription factors E2F4 and E2F5 is mediated by pRb2/p130 and if the presence of JCV T-antigen may impair this shuttling by sequestering pRb2/p130. PMID: 17385710
17. A novel requirement is established for cell cycle regulatory protein E2F4 in the development of the ventral telencephalon. PMID: 17537963
18. The E2F transcription factors are key cell cycle regulators that play important roles in modulating cell proliferation and cell fate. PMID: 17652516
19. normal growth-arrested enterocytes contain p130-E2F4 complexes and T-antigen expression of SV40 destroys these complexes PMID: 17855529
20. Cell cycle genes are the evolutionarily conserved targets of the E2F4 transcription factor PMID: 17957245
21. a subset of the Rb(-/-);E2f4(-/-) chimeras developed either low- or high-grade carcinomas in the urothelium transitional epithelium supporting a key role for Rb in bladder cancer. PMID: 18997819
22. E2F1 expression remained almost unchanged at all stages of chondrocyte differentiation, whereas E2F4 expression increased markedly at the late stage of differentiation. PMID: 19142862
23. the cell cycle repressor E2F4 is essential for the formation of functional memory T cells. A decrease in CD8+ T-lymphocyte compartment would diminish our capacity to control viral infections. PMID: 19306992
24. the results of our studies show a novel role of E2F4 in the early eye development. PMID: 19325228
25. pRB and E2F4 cooperate in placental development, but play largely non-overlapping roles in the development of many embryonic tissues. PMID: 19433082
26. provide evidence that alternative reading frame reduces the interaction of the E2F4-p130 repressor complex with the promoter of xeroderma pigmentosum, complementation group C (XPC) to ensure high-level expression of XPC. PMID: 19644500
27. The absence of E2F4 delayed Myc-induced lymphomagenesis. PMID: 19749980

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KEGG: mmu:104394

STRING: 10090.ENSMUSP00000015003

UniGene: Mm.34554