Recombinant Mouse Transcription factor jun-B (Junb)

1. Data show that JunB is a nonredundant regulator of transcriptional programs that support Th17 cell identity and restrain alternative Th1 and Treg cell fates. PMID: 28824171
2. the present data demonstrates for the first time that JunB plays an important role in the formation of embryonic vascular networks. PMID: 28096474
3. JUNB is a significant modulator of both classical and alternative macrophage activation. PMID: 25472994
4. Study shows that myeloid deletion of JUNB dampens immune polarization and reshapes disease outcomes during infection with both P. berghei and N. brasiliensis by limiting type 1 and type 2 responses, respectively. Thus, JUNB is an important regulator of myeloid responses to both type 1 and type 2 infections in vivo. PMID: 26178310
5. Loss of JunB expression led to increased proliferation and decreased senescence, likely owing to decreased p16(Ink4a) and p21(CIP1) in epithelial cells. PMID: 25526087
6. JunB controls epidermal growth, barrier formation, and proinflammatory responses through direct and indirect mechanisms, pinpointing SQSTM1 as a key mediator of JunB suppression of NF-kappaB-dependent inflammation PMID: 25501661
7. our results suggest a functional cooperation between NFAT1 and JunB in mediating IL-31 gene expression in CD4(+) T cells PMID: 25595785
8. an important role of the A2B receptor-dependent upregulation of JunB in VEGF production and possibly other AP-1-regulated events. PMID: 24136993
9. In experimental hepatitis, the absence of JUNB in immune cells decreased IFN-gamma expression and secretion from NK & NKT cells, leading to reduced STAT1 pathway activation. PMID: 24200694
10. The results show that the junb gene is organized in a nuclear chromatin loop bringing into close spatial proximity the upstream promoter region and the downstream enhancer and that this configuration permits immediate RNA Pol II release on the junb body on binding of LPS-activated NF-kappaB to the enhancer. PMID: 23921639
11. Data suggest that JunB contributes to Id2 repression and provides important input in setting the transcriptional program of the EMT and profibrotic responses to TGF-beta. PMID: 22391036
12. Wwp1 induces JunB ubiquitination and degradation. PMID: 21809421
13. investigation of role of JunB: growth retardation of JunB-deficient mice correlates with strongly reduced fat mass (and is also associated with high lethality); in white adipose tissue, TNFalpha is up-regulated and perilipin is down-regulated PMID: 21540289
14. T cell receptor signaling together with TGF-beta/IL-2 stimulation cooperatively enhance Foxp3 gene expression by maintaining accessible chromatin structure and by actively recruiting key transcription factors JunB and c-Rel. PMID: 21371435
15. JunB is important not only in dividing populations but also in adult muscle, where it is required for the maintenance of muscle size and can induce rapid hypertrophy and block atrophy. PMID: 20921137
16. Smurf1 negatively regulates mesenchymal stem cell proliferation and differentiation by controlling JunB turnover through an ubiquitin-proteasome pathway. PMID: 20200942
17. Data show that Dmp1 directly bound to the genomic loci of Areg, Tsp-1, JunB and Egr1. PMID: 19816943
18. expression of JunB protein has a negative effect on malignant tumor cell proliferation in part through its ability to inhibit AP-1 transactivation PMID: 11862466
19. Transcriptional regulation of JunB, a myeloid differentiation primary response (MyD) gene, during myeloid differentiation is mediated by nuclear factor Y. PMID: 12070012
20. Jun B controls cyclin A during cell cycle regulation in mouse PMID: 12121977
21. may contribute to the molecular processes during contextual memory reconsolidation PMID: 12882314
22. transgenic mice that expressed JunB under the control of the ubiquitin C promoter were partially protected from the transforming potential of the Abelson oncogene. However, transformed B cells eventually escaped from the inhibitory effect of JunB. PMID: 12907453
23. JunB plays a crucial role in endochondral ossification by regulating proliferation and function of chondrocytes and osteoblasts PMID: 14576352
24. These data reveal a novel function of JunB as a positive regulator controlling primarily osteoblast as well as osteoclast activity. PMID: 14769860
25. Vasoactive intestinal peptide binding to VPAC(2) on CD4 T cells specifically induces an up-regulation of the Th2-type transcription factors c-Maf and JunB, which consequently enhances IL-4 and IL-5 production, leading to a Th2-type phenotype. PMID: 15187104
26. phosphorylation of JunB at Ser-79 is essential for its interaction with p300 PMID: 15308641
27. Has a stem cell-specific role, deficiency can result in myeloproliferative disorders. PMID: 15507213
28. JunB mRNA is significantly increased in mitogen-activated protein kinase kinase kinsae deficient cells. PMID: 15558021
29. PTHrP upregulates JunB and reduces cyclin D1 expression while inducing G1 cell cycle arrest in differentiated osteoblasts PMID: 15883646
30. JunB may be a key mediator of PTHrP actions in cementoblasts. PMID: 16418780
31. Enhanced MMP-2 transcription and translation following I/R injury are mediated by induction, via oxidant stress, of discrete AP-1 transcription factor components, JunB and FosB. PMID: 16699069
32. JunB contribute to the development of PU.1 knockdown-induced AML by blocking differentiation and increasing self-renewal. PMID: 17041602
33. NF-kappaB-induced JunB plays a critical role in VEGF regulation and tumor angiogenesis. PMID: 17255940
34. In the absence of JunB, transformed leukemic cells acquire an enhanced proliferative capacity, which presages a more malignant disease. PMID: 17297445
35. JunB is required for the induction of vascular endothelial growth factor A (VEGF-A) by hypoglycemia. PMID: 17341624
36. JunB is a critical regulator of intrinsic mast cell functions including cross-talk with endothelial cells. PMID: 17982078
37. G-CSF is a direct transcriptional target of JunB and mutant epidermis releases large amounts of G-CSF that reach high systemic levels and cause skin ulcerations, myeloproliferative disease and low bone mass. PMID: 18641637

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KEGG: mmu:16477

STRING: 10090.ENSMUSP00000064680

UniGene: Mm.1167