Recombinant Mouse Transient receptor potential cation channel subfamily V member 1 (Trpv1), partial

1. analysis of the temporal mechanism for capsaicin activation of transient receptor potential vanilloid 1 ion channel PMID: 30038260
2. injury-related TRPV1 signal is involved in healing of stromal incision injury in a mouse cornea by selectively stimulating TGFbeta-induced granulation tissue formation. PMID: 29971480
3. TRPV1 SUMOylation is essential for the development of inflammatory thermal hyperalgesia PMID: 29670121
4. Findings indicate brain TRPV cation channel (TRPV1) as potential detector of harmful stimuli and a key player of microglia to neuron communication. PMID: 28489079
5. TRPV1 plays an important role in MAP reward. PMID: 29343767
6. Bladder afferent responses to P2X receptor activation were depressed in TRPV1-/- mice. PMID: 29317663
7. TRPV1 deletion impairs fracture healing, and inhibited osteoclastogenesis and osteogenesis. PMID: 28225019
8. the pain and histamine-dependent itch sensations in mice are impaired due to a decreased phosphorylation level and reduced membrane localization of TRPV1. PMID: 29424270
9. these data revealed a target-related (i.e. capsaicin-evoked) phenotype of TRPV1 Leu206Stop mice closely resembling that of published TRPV1 knockout mice. PMID: 29660342
10. CuS-TRPV1 may represent a therapeutic tool to locally and temporally attenuate atherosclerosis PMID: 29335450
11. Disruption of the association of Sig-1R with TRPV1 by synthetic or natural antagonists leads to degradation of TRPV1 protein and to decreased levels of the ion channel protein as well as to a decrease in TRPV1-associated pain. PMID: 29378958
12. Trpv1 gene deletion results in excessive inflammation, exaggerates cardiac hypertrophy. PMID: 29334670
13. findings indicate that the initiation of the acute heat-evoked pain response in sensory nerve endings relies on three functionally redundant TRP channels, representing a fault-tolerant mechanism to avoid burn injury PMID: 29539642
14. QLQX may improve diabetic cardiac function by regulating AGTR1/ TRPV1-mediated autophagy in STZ-induced diabetic mice. PMID: 29929188
15. TRPV1 increased in the dorsal root ganglion (DRG) and spinal cord (SC) at 3 weeks after CFA injection. The expression levels of downstream molecules such as pPKA, pPI3K, and pPKC increased, as did those of pERK, pp38, and pJNK. Transcription factors (pCREB and pNFkappaB) and nociceptive ion channels (Nav1.7 and Nav1.8) were involved in this process. PMID: 29379798
16. Mitochondrial modulation by all agents selectively increased cytosolic calcium in a subset of TRPA1/TRPV1-expressing (A1/V1+) neurons. There was a significant correlation between antimycin A-induced calcium responses and mitochondrial superoxide in wild-type 'responding' A1/V1+ neurons, which was eliminated in TRPA1-/- neurons, but not TRPV1-/- neurons PMID: 29734380
17. TRPV1 serves a protective role against myocardial apoptosis during ischemia/reperfusion via the PI3K/Akt signaling pathway. PMID: 29286076
18. We conclude that one of the possible regulatory mechanisms of TNF in mechanical orofacial hyperalgesia involves upregulation of the nociceptor TRPV1 PMID: 29132095
19. Data (including data from studies in mutant mice and knockout mice) suggest that dietary basic amino acids L-ornithine and L-lysine stimulate gastrointestinal motility via activation of Trpv1 in small intestine; dietary L-arginine suppresses gastrointestinal motility. PMID: 28722259
20. TRPV1 activation on sensory neurons (SN) innervating bone by the acidic cancer microenvironment in bone contributes to SN activation and bone pain. PMID: 28516219
21. TRPV1 differentially contributes to spontaneous and bite-evoked pain during masseter inflammation, but both types of muscle pain are mediated by TRPV1-expressing nociceptors as well as NK1-expressing second-order neurons. PMID: 28669862
22. High TRPV1 expression is associated with maternal fever-associated birth defects. PMID: 29018170
23. These results suggest that neuronal TRPV1 signaling in periodontal tissue is crucial for the regulation of osteoclastogenesis via the neuropeptide CGRP. PMID: 27388773
24. RAGE-dependent potentiation of TRPV1 currents in sensory neurons exposed to high glucose. PMID: 29474476
25. data demonstrate that lactate at physiologically relevant concentrations is a potent endogenous inhibitor of TRPV1. PMID: 27827430
26. Data suggest that cold stress can induce brain injury, possibly through TRPV1 activation and the PI3K/Akt signaling pathway. PMID: 28669718
27. Both TRPA1 and TRPV1 channels are required for generating spontaneous scratching in a mouse model of allergic contact dermatitis. PMID: 29081531
28. Both TRPV1 and GRP are part of a new mesoaccumbal glutamatergic pathway. PMID: 27762319
29. Activation of TRPV1 might accelerate the development of the PAR2-triggered referred hyperalgesia in mice. PMID: 29289470
30. These results indicate that TRPV1 is important for activating proinflammatory STAT3 signaling and thermoregulation-associated brain pathways in the brain. PMID: 27188969
31. Dual FAAH and TRPV1 blockage inhibits contextual fear memory. PMID: 28583049
32. TRPA1, TRPV1 and mast cells play an indispensable role in the development of toluene-2,4-diisocyanate-elicited airway hyperreactivity PMID: 27126687
33. This study demonstrated that botulinum neurotoxin A doenregulation of Trpv1 in the dorsal root ganglia in mice PMID: 28410268
34. that the augmented expression of TRPV1 in alpha-GalA(-/0) nociceptors may underly at least in part their increased heat sensitivity PMID: 27531673
35. This study showed that spontaneous pain is dependent on the virulence determinant agr and bacterial pore-forming toxins (PFTs). The cation channel, TRPV1, mediated heat hyperalgesia as a distinct pain modality. PMID: 29295977
36. Study suggests that deletion of TRPV1 receptors prevents reduction of hyperthermic seizure susceptibility in older mouse pups via a mechanism independent of hyperthermia-induced respiratory alkalosis, but possibly involves impaired development of thermoregulatory mechanisms, although at present, the mechanisms remain unknown. PMID: 27810513
37. 4-Hydroxynonenal dependent alteration of TRPV1-mediated coronary microvascular signaling. PMID: 27682362
38. Depending on the concentration, lidocaine employs TRPV1, TRPA1 and intracellular Ca2+ stores to induce a Ca2+-dependent release of the neuropeptide CGRP. Lidocaine-evoked cell death does not seem to require Ca2+ influx through TRPV1 or TRPV1 PMID: 29141003
39. However, the mechanism that induces release of IL-6 from skeletal muscle cells remains unknown. Here we show that heat increases IL-6 in skeletal muscle cells through the transient receptor potential vannilloid 1, PKC, and cAMP response element-binding protein signal transduction pathway. PMID: 27979980
40. Blockade of TRPV1, through genetic deletion or systemic or intra-nucleus accumbens (NAc) pharmacological means, inhibited morphine-induced CPP in mice. In addition, p38 MAPK inhibition blocked development of morphine conditioned place preference (CPP) as well. Moreover, blockade of either NAc p38 MAPK or TRPV1 dampened protein expression levels of p-p38 MAPK, AC1, and p-NF-kappaB which are normally induced by morphine ... PMID: 28734766
41. Results suggest the involvement of TRPV1 in allergic asthma. PMID: 27255083
42. Sensitization was relieved by pharmacological block of TRPV1 afferents, but not of myelinated neurons. In spinal cord slice recordings, we could optogenetically trigger an activity-dependent potentiation of presynaptic neurotransmission in the spinal dorsal horn that relied on Cav3.2 channel activity. This neuronal-activity-induced USP5 upregulation may underlie a protective, transient sensitization of the pain pathway. PMID: 27974205
43. antiobesity effect of KetoA was caused by TRPV1 activation-mediated browning in WAT. KetoA produced in the gut could therefore be involved in the regulation of host energy metabolism. PMID: 28754711
44. studies identified TRPV4 as a channel that contributes to both histamine- and chloroquine-induced itch and indicated that the function of TRPV4 in itch signaling involves TRPV1-mediated facilitation. PMID: 27436359
45. These findings indicate the EPO-induced Ca(2+) influx via the activation of the PLC-gamma1 signalling pathway, which leads to TRPV1 activation and consequently increases...angiogenesis. PMID: 27232578
46. The activation of TRPV1 channels by dietary capsaicin triggers browning of white adipose tissue to counteract obesity. The results suggest that activation of TRPV1 channels is a promising strategy to counter obesity. PMID: 27174467
47. study demonstrates that the anti-inflammatory effects of N-Arachidonoyl dopamine are mediated by TRPV1 expressed by nonhematopoietic cells and provide data suggesting that neuronal TRPV1 may mediate NADA's anti-inflammatory effects PMID: 28701511
48. These findings demonstrate functional expression and the precise ultrastructural localization of TRPA1 and TRPV1 ion channels in freshly isolated mouse CMs. Crosstalk between TRPA1 and TRPV1 may be important in mediating cellular signaling events in cardiac muscle PMID: 27144598
49. TRPA1 and TRPV1 appear to contribute to the propofol-mediated antagonism of U46619-induced constriction in murine coronary microvessels that involves activation of NOS and BKCa. PMID: 28644897
50. Study showed that activation of TRPV1 and blockade of NMDA receptors produced antidepressant-like effects in male mice following amphetamine withdrawal, and these receptors are involved in amphetamine withdrawal-induced depressive-like behaviors; rapid antidepressant-like effects of capsaicin in forced swimming test and splash test are partly mediated by NMDA receptors PMID: 27167081

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KEGG: mmu:193034

STRING: 10090.ENSMUSP00000099585

UniGene: Mm.447485