Recombinant Mouse Tumor necrosis factor alpha-induced protein 3 (Tnfaip3)

1. In mice, deletion of A20 in microglia increases microglial cell number and affects microglial regulation of neuronal synaptic function. Microglia A20 deficiency also exacerbates multiple sclerosis-like disease, due to hyperactivation of the Nlrp3 inflammasome leading to enhanced interleukin-1beta secretion and CNS inflammation. PMID: 29789522
2. A20 dimers bind linear ubiquitin to stabilize the Ripoptosome and potentiate its apoptosis-inducing activity. PMID: 30209212
3. At least in the subcutaneous fat of humans and mice, the levels of PGC-1a decrease during obesity, while its physical association with A20 increases. PMID: 29678181
4. T cell-specific A20 limited the expansion but reduced apoptosis and necroptosis of Listeria-specific CD8(+) T cells, resulting in an impaired pathogen control in primary but improved clearance in secondary infection. PMID: 28004776
5. study reveals a critical role of IL-17RC in maintaining baseline A20 production and a novel role of the IL-17RC-A20 axis in controlling JNK isoform-dependent tumor-specific homeostatic proliferation. PMID: 28562353
6. Deletion of TT>A enhancer results in inflammatory arthritis. PMID: 29440643
7. The data demonstrate that miR-125b regulates nasopharyngeal carcinoma cell proliferation and apoptosis by targeting A20/NF-kappaB signaling pathway, and miR-125b acts as oncogene, whereas A20 functions as tumor suppressor. PMID: 28569771
8. Mice with A20 deficient B cells are prone to food allergy. PMID: 27825134
9. Tnfaip3, an anti-inflammatory gene, is located precisely underneath the linkage peak and contains two non-synonymous SNPs leading to conservative amino acid substitutions. PMID: 28116503
10. Hepatitis C virus core protein ligates gC1qR to induce A20 expression in macrophages via P38, JNK and NF-kappaB signaling pathways, which leads to a low-grade chronic inflammation during HCV infection. PMID: 27183919
11. These results suggest that Leishmania exploits A20 and UCP2 to impair inflammasome activation for disease propagation PMID: 28765172
12. holding thymic production of natural Treg cells in check, A20 integrates Treg cell activity and increased effector T cell survival into an efficient CD4(+) T cell response PMID: 28842469
13. these studies establish A20 as a crucial hepatoprotective factor. PMID: 27253414
14. These results suggested that A20 is involved in regulating intracerebral hemorrhage-induced inflammatory injury in both the central and peripheral system PMID: 27986908
15. the ubiquitin-modifying enzyme TNFAIP3/A20, an upstream regulator of T cell receptor (TCR) signaling in T cells, is an essential cell-intrinsic regulator of Natural killer T differentiation. PMID: 27551157
16. these data reveal a crucial role of A20 in regulating the immunomodulatory activities of mesenchymal stem cells. PMID: 27028905
17. Therefore, A20 acts as a novel endogenous regulator of STAT1 that prevents onset of enthesitis. PMID: 27551052
18. This study demonstrated that miR-136-5p affected the expression of A20 in IL-17-stimulated astrocytes. PMID: 28355611
19. Our data suggest that NAOs have a beneficial preventive effect in septic shock correlated with the enhancement of IL-10 via the induction of A20 and COX-2. PMID: 28363868
20. Forced expression of A20 resulted in decreased expression of key markers of lipogenesis and adipogenesis, such as sterol regulatory element binding protein 1c (SREBP-1c) and adipogenesis (aP2), leading to less lipids accumulation in differentiated 3T3-L1 cells PMID: 27443844
21. these results suggest that Mycobacterium fortuitum-induced activation of host proinflammatory responses is negatively regulated through TLR2-dependent A20 expression. PMID: 26940588
22. knockdown of A20 in tumor site inhibited tumor growth at least through inducing the apoptosis of MDSCs. A20 might be a potential target in anticancer therapy. PMID: 26561336
23. MiR-221 directly targets A20, a master regulator of NF-kappaB and MAPK signaling, and thus represses inflammatory signaling. Restoration of A20 in macrophages abolished the stimulatory effect of miR-221 on production of proinflammatory cytokines. PMID: 26549234
24. A20 targets caspase-8 and FADD to protect HTLV-I-infected cells. PMID: 26437781
25. Our results show that miR-873 elevates A20 levels and inhibits morphine-induced macrophage apoptosis. PMID: 25989384
26. a significant influence of Tnfaip3 depletion on the expression of Tsc22d3, Pex7, Rap2a, Slc2a3, and Gap43 in stress response PMID: 26546835
27. we propose a mechanism of action by which A20 expression in club cells controls inflammation and antiviral cytotoxic T cell responses in response to influenza virus infection. PMID: 26815999
28. TNFAIP3 restricts MTOR signaling and promotes autophagy, providing new insight into the manner in which MTOR and autophagy regulate survival in CD4 T cells. PMID: 26043155
29. autophagy downregulates A20 in F4/80hi macrophages through p62-associated autophagic sequestration and that the resulting NFkappaB activation induces expression of chemokines at an early stage of Candida infection PMID: 25609235
30. Up-regulated A20 promotes proliferation, regulates cell cycle progression and induces chemotherapy resistance of acute lymphoblastic leukemia cells. PMID: 26159495
31. A20 knockout mice develop spontaneous intestinal defects. PMID: 25267258
32. ERRa is a negative regulator of TLR-induced inflammatory responses through inducing Tnfaip3 transcription and controlling the metabolic reprogramming. PMID: 26200012
33. these studies link A20 and the ubiquitination of RIPK3 to necroptotic cell death and suggest additional mechanisms by which A20 might prevent inflammatory disease. PMID: 25939025
34. Data suggest that the seventh zinc finger motif of A20 plays important role in NFkappaB-mediated apoptosis induced by tumor necrosis factor-alpha; A20 appears to bind and thus down-regulate inhibitor of apoptosis proteins cIAP1/2. PMID: 25911380
35. Brucella intracellular growth within macrophages occurs through up-regulation of A20 thereby limiting activation and macrophages cell death. PMID: 25433453
36. these findings show that DC-specific A20 preserves immune homeostasis in steady-state conditions and is also required for LPS tolerance. PMID: 25472594
37. Lack of the ubiquitin-editing enzyme A20 results in loss of hematopoietic stem cell quiescence. PMID: 25624445
38. inhibits inflammation via decreasing pro-IL-1beta-associated ubiquitination in a RIPK3-dependent manner PMID: 25607459
39. A20 deficiency causes spontaneous neuroinflammation in mice. PMID: 25026958
40. The findings identify A20 as a mediator of adiponectin anti-inflammatory action in white adipose tissue and a potential target for mitigating obesity-related pathology. PMID: 25190567
41. Our results thus indicate that the deubiquitinase activity of A20 is dispensable for normal NF-kappaB signaling. PMID: 24878851
42. These results demonstrate that A20 plays essential roles in the homeostasis of adult hematopoiesis by preventing apoptosis and inflammation. PMID: 24498102
43. results reveal A20 as a novel negative regulator of Nlrp3 inflammasome activation, and describe A20(myel-KO) mice as the first experimental model to study the role of inflammasomes in the pathology of rheumatoid arthritis PMID: 25043000
44. The anaphase-promoting complex protein 5 (AnapC5) associates with A20 and inhibits IL-17-mediated signal transduction. PMID: 23922952
45. A20-deficient mast cells exacerbate inflammatory responses in vivo. PMID: 24453940
46. Bcl10 is an essential regulator for A20 gene expression. PMID: 23677497
47. Tnfaip3 was over-expressed in microglia following knockdown of miR-29b. PMID: 24236890
48. studies define the critical opposing functions of DREAM and USF1 in inhibiting and inducing A20 expression PMID: 24487321
49. Tnfaip3 is regulated by both NF-kappaB and p38-dependent C/EBPbeta PMID: 24023826
50. A20 zinc finger protein plays an anti-inflammatory role and protects against liver injury associated with trauma combined with lipopolysaccharide challenge. PMID: 24055365

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KEGG: mmu:21929

STRING: 10090.ENSMUSP00000019997

UniGene: Mm.116683