Product Details

Purity

Greater than 95% as determined by SDS-PAGE.
Greater than 95% as determined by SEC-HPLC.

Target Names

Uniprot No.

P21614

Alternative Names

Gc; Vitamin D-binding protein; DBP; VDB; Gc-globulin; Group-specific component

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

17-476aa

Target Protein Sequence

LERGRDYEKDKVCNELAMLGKEDFRSLSLILYSRKFSSSTFEQVNQLVKEVVSLTEECCAEGADPTCYDTRTSELSVKSCESDAPFPVHPGTPECCTKEGLERKLCMAALSHQPQEFPTYVEPTNDEICEAFRRDPKGFADQFLYEYSSNYGQAPLPLLVAYTKNYLSMVGSCCTSANPTVCFVKERLQMKHLSLLTTMSNRVCSQYAAYGKEKSRLSHLIKLAQKVPTANLENVLPLAEDFTEILSRCCESTSEDCMASELPEHTIKICQNLSKKNSKFEECCQENTPMNIFMCTYFMPAAEPLQLPAIKLPTGKDLCGQSTTQAMDQYTFELSRRTQVPEVFLSKVLEPTLKTLRECCDTQDSVACFSTQSPLLKRQLTSFIEKGQEMCADYSENTFTEYKKKLAERLRTKTPNTSPAELKDMVEKHSDFASKCCSINSPPLYCSSQIDAEMIDTLQS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

53.9kDa

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal 6xHis-tagged

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

The Recombinant Mouse Vitamin D-binding protein (Gc) is a top-tier recombinant protein designed for complex scientific explorations. This protein mirrors the attributes of the Vitamin D-binding protein, also recognized as DBP, VDB, Gc-globulin, or Group-specific component, native to the Mouse species. Expertly manufactured in a yeast expression system, this full-length mature protein ensures an accurate representation of the original protein, enhancing the reliability of your research findings.

The Recombinant Mouse Vitamin D-binding protein (Gc) covers the expression region from the 17th to the 476th amino acid sequence of the natural protein. Featuring an N-terminal 6xHis-tag, this protein ensures easy and efficient purification and detection during your experiments. The product purity exceeds 85% as confirmed by SDS-PAGE, providing you with a high-quality protein for your experimental needs. The Recombinant Mouse Vitamin D-binding protein (Gc) is available in both liquid and lyophilized powder forms, making it adaptable to your laboratory and storage requirements.

Target Background

Function

Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.

Gene References into Functions

results show DBP is a significant chemotactic cofactor in vivo and not specific for C5a, suggesting that this ubiquitous plasma protein may have a more significant role in neutrophil recruitment than previously recognized PMID: 23752613
Effects of estradiol on the endocytic transport of vitamin D carrier protein in hepatocytes. PMID: 23416408
Data suggest that whereas DBP is important to total circulating 1,25(OH)(2)D(3) and sequesters extracellular levels of this hormone both in vivo and in vitro, the binding protein does not influence the hormone's biologically active pool. PMID: 18372326

Subcellular Location

Secreted.

Protein Families

ALB/AFP/VDB family

Database Links

KEGG: mmu:14473

STRING: 10090.ENSMUSP00000046636

UniGene: Mm.196595

Code	CSB-YP009306MO
Abbreviation	Recombinant Mouse Vitamin D-binding protein
MSDS	MSDS Datasheet
Size	$368
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Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel. The purity of Gc was greater than 95% as determined by SEC-HPLC
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Recombinant Mouse Vitamin D-binding protein (Gc)

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