GC

GC, also known as vitamin D-binding protein (DBP) or group-specific component, is a plasma glycoprotein synthesized mainly in the liver. It binds and transports vitamin D and its metabolites, regulates vitamin D homeostasis, and also participates in iron metabolism and immune modulation.
Abnormal GC expression or mutations are associated with vitamin D deficiency, iron disorders, and certain autoimmune diseases. Recombinant GC preparations and targeted modulators are under preclinical study, aiming to improve vitamin D delivery and treat related metabolic and immune disorders.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP009306HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) GC.

GC Recombinant Monoclonal Antibody (CSB-RA089046A0HU)

Validated Data

Overlay Peak curve showing HepG2 cells stained with CSB-RA089046A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*10⁶cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*10⁶cells) used under the same conditions. Acquisition of >10,000 events was performed.

The following GC reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

GC Antibodies

GC Proteins

GC ELISA Kits

GC Antibodies

GC Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA07569A0Rb	GC Antibody	Human	ELISA, WB, IHC
CSB-PA07569B0Rb	GC Antibody, HRP conjugated	Human	ELISA
CSB-PA07569C0Rb	GC Antibody, FITC conjugated	Human
CSB-PA07569D0Rb	GC Antibody, Biotin conjugated	Human	ELISA
CSB-PA009306GA01HU	GC Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA009306ESR1HU	GC Antibody	Human, Mouse	ELISA, WB, IHC
CSB-PA002082	GC Antibody	Human,Monkey	WB, ELISA
CSB-PA964049	GC Antibody	Human	ELISA,WB,IHC
CSB-PA944210	GC Antibody	Human	ELISA,IHC
CSB-RA089046A0HU	GC Recombinant Monoclonal Antibody	Human	ELISA, FC

GC Proteins

GC Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP009306HU	Recombinant Human Vitamin D-binding protein (GC), partial	Yeast
CSB-EP009306HU	Recombinant Human Vitamin D-binding protein (GC), partial	E.coli
CSB-BP009306HU CSB-MP009306HU CSB-EP009306HU-B	Recombinant Human Vitamin D-binding protein (GC)	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

GC ELISA Kit

GC ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E11859h	Human Vitamin D-binding protein,DBP ELISA Kit	serum, plasma, tissue homogenates	0.078 ng/ml

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GC

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