Recombinant Mouse Wolframin (Wfs1), partial

1. the functional link between Wfs1 and D1-like dopamine receptors is evolutionarily conserved and plays an important role in adjusting behavioral reactions to environmental stimuli. PMID: 28267787
2. Three muscle-specific nuclear membrane proteins, NET39, Tmem38A, and WFS1, direct specific myogenic genes to the nuclear periphery to facilitate their repression during myogenesis. PMID: 27264872
3. WFS1-knockout mice develop a metabolic phenotype characterized with several physiological dysfunctions. PMID: 26733243
4. RNA-sequencing of pancreatic islets from WFS1-deficient mice showed that Trpm5 is downregulated and the pathways related to tissue morphology, and endocrine system development/function/molecular transport network are influenced. PMID: 27053292
5. Study demonstrates that Wfs1 deficiency in mice induces alterations in specific behavioural effects of ethanol like the increased anxiolytic-like and hypnotic action, but the decreased sedation PMID: 25725334
6. Na-pump alpha1 -subunit mRNA was significantly decreased in the dorsal striatum and midbrain of Wfs1-deficient homozygous animals compared with wild-type littermates. PMID: 25385034
7. Results reveal a role for WFS1 in the negative regulation of SERCA and provide further insights into the function of WFS1 in calcium homeostasis. PMID: 25274773
8. Energy metabolism and thyroid function of mice with deleted wolframin (Wfs1) gene. PMID: 24710642
9. We show that the expression of Wfs1 starts during late embryonic development in the dorsal striatum and amygdala, then expands broadly at birth, possessing several transitory regions during maturation. PMID: 24694561
10. Present results indicate that the effects of Wfs1-deficiency on behavioral rhythmicity are subtle suggesting that Wfs1 is not a major player in the neural networks responsible for circadian rhythmicity of behavior. PMID: 22800759
11. Gene expression profiling was performed in Wfs1-deficient mice. PMID: 22028430
12. Sex differences in the development of diabetes in mice with deleted wolframin (Wfs1) gene. PMID: 21031341
13. ER stress induces Smurf1 degradation and WFS1 up-regulation PMID: 21454619
14. homozygous Wfs1 mutant mice (AUC = 0.212 nM/mul h) show significantly decreased striatal dopamine output in response to high-concentration [K+] challenge as compared with wild-type PMID: 20972658
15. Wolfram syndrome 1 gene (WFS1) product localizes to secretory granules and determines granule acidification in pancreatic beta-cells. PMID: 21199859
16. a role for WFS1 in the negative regulation of ER stress signaling and in the pathogenesis of diseases involving chronic, unresolvable ER stress, such as pancreatic beta cell death in diabetes. PMID: 20160352
17. Data show that the impaired fertility of Wfs1KO male mice is most likely due to changes in sperm morphology and reduced number of spermatogenic cells. PMID: 19664290
18. may play a role in inner ear ion homeostasis as maintained by the canalicular reticulum PMID: 12649740
19. The role of WFS1 in the etiology of Wolfram syndrome is examined in WFS1 mutant mice. PMID: 15056606
20. Data indicate that endoplasmic reticulum (ER)-stress and N-glycosylation play important roles in WFS1 expression and stability, and also suggest regulatory roles for this protein in ER-stress induced cell death. PMID: 15522226
21. Wfs1 expression, which is localized to beta- and delta-cells in pancreatic islets, increases in response to endoplasmic reticulum stress, suggesting a functional link between Wfs1 and ER stress PMID: 15994758
22. WFS1-deficiency activates the ER stress response specifically in beta-cells, causing beta-cell loss through impaired cell cycle progression and increased apoptosis. PMID: 16571599
23. After cat odor exposure the expression of Wfs1 gene was significantly lower in the mesolimbic area and temporal lobe of Bl6 mice compared to 129Sv strain. PMID: 17884289
24. Wfs1 knockout mice did not show abnormalities in circadian rhythm and periodic fluctuation of wheel-running activity but had retardation in emotionally triggered behavior, decreased social interaction, and altered behavioral despair PMID: 18343518
25. Lack of Wfs1 protein function can be related to several neurological and psychiatric symptoms found in Wolfram syndrome. PMID: 18551525
26. Wfs1 mRNA and protein were widely distributed in normal mouse visual system. This evidence may provide clues as to physiological role of Wfs1 protein in biology of vision and help to explain selective vulnerability of optic nerve to WFS1 loss-of-function. PMID: 18613120
27. Data show that Wfs1-deficient mice display impaired behavioural adaptation in stressful environment. PMID: 19041897
28. Wfs1-deficient beta cells are susceptible to endoplasmic reticulum stress; increased insulin causes prompts apoptosis in such cells in vivo. PMID: 19190890
29. Results suggest that further studies are needed to describe biochemical and molecular changes of the growth hormone axis as well as in other hormones to clarify their role in growth retardation in the Wfs1 mutant. PMID: 19293327
30. Wfs1 mRNA was widely distributed in the normal mouse brain during postnatal development. PMID: 19428703
31. The present study demonstrated that increased anxiety of Wfs1-deficient mice is probably linked to reduced expression of Gabra1 and Gabra2 genes in the frontal cortex and temporal lobe. PMID: 19477223

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KEGG: mmu:22393

STRING: 10090.ENSMUSP00000048053

UniGene: Mm.20916