Recombinant Pig Clusterin(CLU)

Product Type Recombinant Protein
Uniprot No. Q29549
Abbreviation CLU
Species Sus scrofa (Pig)
Gene Names CLU
Protein Names Recommended name: Clusterin Alternative name(s): CP40 Complement cytolysis inhibitor Short name= CLI Cleaved into the following 2 chains: 1. Clusterin beta chain 2. Clusterin alpha chain
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
HGNC 29094
RGD 1307222
MGI 1921398
References
Function Functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Promotes apoptosis when in the nucleus. Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation (By similarity).
Subcellular Location Secreted, Cytoplasmic vesicle, secretory vesicle, chromaffin granule, Nucleus, Cytoplasm, Mitochondrion membrane, Peripheral membrane protein, Cytoplasmic side, Cytoplasm, cytosol, Microsome, Endoplasmic reticulum
Protein Families Clusterin family
Tissue Specificity Highest levels in brain and liver; lower levels are detected in other tissues, including the aorta. Abundant in senescent porcine pituitary colloids.
Database Links

KEGG: ssc:397025

STRING: 9823.ENSSSCP00000010325

UniGene: Ssc.11992

Pathway Complement and coagulation cascades

Product Details for Different Expression Systems

Product Name Recombinant Pig Clusterin(CLU),Yeast
Code CSB-YP005595PI
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence KE LQEMSTEGSK YVNKEIKNAL KEVKQIKTLI EQSNEERKSL LSSLEEAKKK KEDALNDTRD TETKLKGSQG LCNETMMALW EECKPCLKQT CMKFYARVCR SGSGLVGHQL EEFLNQSSPF YFWINGDRID SLMENDRQQS HVMDIMEDSF NRASNIMDEL FQDRFFNREP FDTQFFSPFG SSHRGSLFFN PKSRFARNIM PFPLFTDLNY HDMFQPFFDM IHQAQQAMDA HLHRIPYHFP EAGVPENSND RAVCKEIRHN STGCLRMKDQ CEKCREILSV DCSASNSSQM QLRQELYTSL QMAEKFSKLY DQLLQSYQQK MLNTSSLLKQ LNEQFSWVSQ LANLTQNDDR YYLQVTTVNS HGSDPSVPSG LTKVVVKLFD SYPITLIIPQ EVSDPKFMET VAEEALQQYR QRSREE
Expression Region 29-446
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Pig Clusterin(CLU),E.coli
Code CSB-EP005595PI
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence KE LQEMSTEGSK YVNKEIKNAL KEVKQIKTLI EQSNEERKSL LSSLEEAKKK KEDALNDTRD TETKLKGSQG LCNETMMALW EECKPCLKQT CMKFYARVCR SGSGLVGHQL EEFLNQSSPF YFWINGDRID SLMENDRQQS HVMDIMEDSF NRASNIMDEL FQDRFFNREP FDTQFFSPFG SSHRGSLFFN PKSRFARNIM PFPLFTDLNY HDMFQPFFDM IHQAQQAMDA HLHRIPYHFP EAGVPENSND RAVCKEIRHN STGCLRMKDQ CEKCREILSV DCSASNSSQM QLRQELYTSL QMAEKFSKLY DQLLQSYQQK MLNTSSLLKQ LNEQFSWVSQ LANLTQNDDR YYLQVTTVNS HGSDPSVPSG LTKVVVKLFD SYPITLIIPQ EVSDPKFMET VAEEALQQYR QRSREE
Expression Region 29-446
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Pig Clusterin(CLU),Baculovirus
Code CSB-BP005595PI
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence KE LQEMSTEGSK YVNKEIKNAL KEVKQIKTLI EQSNEERKSL LSSLEEAKKK KEDALNDTRD TETKLKGSQG LCNETMMALW EECKPCLKQT CMKFYARVCR SGSGLVGHQL EEFLNQSSPF YFWINGDRID SLMENDRQQS HVMDIMEDSF NRASNIMDEL FQDRFFNREP FDTQFFSPFG SSHRGSLFFN PKSRFARNIM PFPLFTDLNY HDMFQPFFDM IHQAQQAMDA HLHRIPYHFP EAGVPENSND RAVCKEIRHN STGCLRMKDQ CEKCREILSV DCSASNSSQM QLRQELYTSL QMAEKFSKLY DQLLQSYQQK MLNTSSLLKQ LNEQFSWVSQ LANLTQNDDR YYLQVTTVNS HGSDPSVPSG LTKVVVKLFD SYPITLIIPQ EVSDPKFMET VAEEALQQYR QRSREE
Expression Region 29-446
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Pig Clusterin(CLU),Mammalian cell
Code CSB-MP005595PI
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence KE LQEMSTEGSK YVNKEIKNAL KEVKQIKTLI EQSNEERKSL LSSLEEAKKK KEDALNDTRD TETKLKGSQG LCNETMMALW EECKPCLKQT CMKFYARVCR SGSGLVGHQL EEFLNQSSPF YFWINGDRID SLMENDRQQS HVMDIMEDSF NRASNIMDEL FQDRFFNREP FDTQFFSPFG SSHRGSLFFN PKSRFARNIM PFPLFTDLNY HDMFQPFFDM IHQAQQAMDA HLHRIPYHFP EAGVPENSND RAVCKEIRHN STGCLRMKDQ CEKCREILSV DCSASNSSQM QLRQELYTSL QMAEKFSKLY DQLLQSYQQK MLNTSSLLKQ LNEQFSWVSQ LANLTQNDDR YYLQVTTVNS HGSDPSVPSG LTKVVVKLFD SYPITLIIPQ EVSDPKFMET VAEEALQQYR QRSREE
Expression Region 29-446
Protein Description Full Length of Mature Protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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