Recombinant Rabbit Voltage-dependent L-type calcium channel subunit alpha-1C(CACNA1C) ,partial

Code CSB-YP004399RB
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Source Yeast
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Code CSB-EP004399RB
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Source E.coli
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Code CSB-EP004399RB-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP004399RB
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Source Baculovirus
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Code CSB-MP004399RB
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names CACNA1C
Uniprot No. P15381
Alternative Names CACNA1C; CACH2; CACN2; CACNL1A1; CCHL1A1Voltage-dependent L-type calcium channel subunit alpha-1C; Calcium channel; L type; alpha-1 polypeptide; isoform 1; cardiac muscle; Smooth muscle calcium channel blocker receptor; CACB-receptor; Voltage-gated calcium channel subunit alpha Cav1.2
Species Oryctolagus cuniculus (Rabbit)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable).
Gene References into Functions
  1. (CaV1.2 alpha-1) Cav1.2 alpha-1 binds specifically to CaMKII in forebrain to enhance regulatory phosphorylation. PMID: 19840220
  2. a model where high affinity binding of Ca(V)beta to the I-II linker of Ca(V)alpha1 largely accounts for Ca(V)beta-induced plasma membrane targeting of Ca(V)1.2 PMID: 20478999
  3. The identification of seven PKC phosphorylation sites within the alpha(1c) subunit, is reported. PMID: 19527072
Subcellular Location Cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma; Multi-pass membrane protein. Perikaryon. Cell junction, synapse, postsynaptic density membrane. Cell projection, dendrite. Cell membrane, sarcolemma, T-tubule.
Protein Families Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1C subfamily
Tissue Specificity Expression in cardiac muscle. In lung, expressed in airway and vascular smooth muscle cells.
Database Links

KEGG: ocu:100101555

UniGene: Ocu.1835

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