Recombinant Rat Bone morphogenetic protein 2(Bmp2)

Code CSB-YP002736RA
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Source Yeast
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Code CSB-EP002736RA
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Source E.coli
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Code CSB-EP002736RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP002736RA
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Source Baculovirus
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Code CSB-MP002736RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Bmp2
Uniprot No. P49001
Alternative Names Bmp2; Bmp-2Bone morphogenetic protein 2; BMP-2; Bone morphogenetic protein 2A; BMP-2A
Species Rattus norvegicus (Rat)
Expression Region 280-393
Target Protein Sequence Q AKHKQRKRLK SSCKRHPLYV DFSDVGWNDW IVAPPGYHAF YCHGECPFPL ADHLNSTNHA IVQTLVNSVN SKIPKACCVP TELSAISMLY LDENEKVVLK NYQDMVVEGC GCR
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4.
Gene References into Functions
  1. study suggests that NT-3 may be an osteogenic and angiogenic factor upstream of BMP-2 and VEGF in bony repair, and further studies are required to investigate whether NT-3 may be a potential target for preventing growth plate faulty bony repair or for promoting bone fracture healing. PMID: 26763079
  2. The synergistic effect of BMP-2+phenamil on bone regeneration was further confirmed in a critical-sized rat mandibular bone defect by implanting polymer scaffolds designed to slowly release the therapeutic molecules. PMID: 27771997
  3. IGFBP4 overexpression impaired BMP2-induced osteogenic differentiation potential of young MSCs, whereas IGFBP4 knockdown restored the osteogenic potency of aged MSCs. Moreover, IGFBP4 knockdown stimulated the activation of Erk and Smad by increasing phosphorylation. PMID: 28595186
  4. Data suggest that Cox2/Ptgs2 (cyclooxygenase-2) plays role in exacerbated of activation of Bmp2 (bone morphogenetic protein 2) signaling in pulmonary microvascular endothelial cells; this promotes macrophage activation/accumulation and pathological angiogenesis in lung in a rat model of hepatopulmonary syndrome. PMID: 28642034
  5. downregulation of Bmpr1a and Bmp2 at the time of cloacal separation into the primitive rectum and UGS might be related to the development of anorectal malformations. PMID: 27477499
  6. 50% ethanol extracts of root-bark of Sambucus Williamsii Hance can accelerate fracture healing by recruitment of osteoblasts at the fracture site and through up-regulation of the BMP-2 signaling pathway. PMID: 27178636
  7. A short-term zinc-deficient diet decreases bone formation through down-regulated BMP2 in rat femurs. PMID: 26931551
  8. NF-kappaB stimulates BMP-2 mRNA expression in rat and human beta cells upon IL-1b cytokine exposure. PMID: 26308798
  9. Gelatinases promote vascular calcification by upregulating BMP-2 which induces expression of RUNX2 and Msx-2, two proteins associated with phenotype transition of VSMCs in vascular calcification. PMID: 26797522
  10. establish the feasibility of combining NELL-1 with BMP2 to improve clinical bone regeneration and provide mechanistic insight into canonical Wnt pathway activity during NELL-1 and BMP2 osteogenesis PMID: 26772960
  11. spinal cord injury(SCI) can cause severe impairment of motor activity in rats. Seven days after SCI, the local expression of BMP-2/4 had obviously increased; noggin can effectively inhibit the expression of BMP-2/4 and reduce impairment PMID: 26345843
  12. findings describe a positive regulatory effect of LMP-1 on BMP-2 expression and BMP-2-mediated osteogenesis. This effect occurs through activation of ERK1/2 pathway and subsequent upregulation of Runx2 transactivity. PMID: 25677945
  13. VDR may mediate the increased expression levels of BMP2, Runx2 and Osterix by positively regulating calcium levels in primary primary renal tubular epithelial cells. PMID: 25823394
  14. EPCs-BMP2 further improved endothelium repair. PMID: 25896232
  15. ERRgamma plays a key role in vascular calcification by upregulating the BMP2 signaling pathway. PMID: 26404484
  16. Dexamethasone augmented ectopic bone formation induced by bone morphogenetic protein-2. PMID: 25659106
  17. the BMP-2-SMAD-5 pathway has a role in hydroxyapatite differentiation of aortic smooth muscle cells into osteoblast-like cells PMID: 25725805
  18. On day 21, 50 ng/mL BMP2/7 could antagonize the inhibitive effects of ATRA and significantly enhance osteogenesis of bone marrow stromal cells. PMID: 24111806
  19. these data provide evidence for BMP-2 as a new autocrine/paracrine factor that regulates cardiomyocyte mechanotransduction and adaptation to increased mechanical stretch. PMID: 25218476
  20. Knockdown of BMP2 or Noggin blocked phosphate-induced calcification. PMID: 25446167
  21. Osteogenic differentiation was significantly promoted in the triple combination treatment of BMP-2, VEGF and bFGF compared with the single or binary combination treatments. PMID: 24306516
  22. BMP2 is a potential regulator of nigrostriatal pathway development. PMID: 24682653
  23. The data indicated that inhibition of Smad4 diminished both AdBMP2 induced and basal histone acetylation levels in the promoter regions of GATA4 and Nkx2.5. PMID: 24866243
  24. Endothelial progenitor cell therapy can promote fracture healing and this may occur by increasing BMP-2 levels and thus stimulating angiogenesis and osteogenesis. PMID: 24464097
  25. IGF-1 and BMP-2 together mediate PGE2-induced adipogenic differentiation of tendon stem cells in vitro via a CREB- and Smad-dependent mechanism. PMID: 24416413
  26. Inhibition of histone H3 acetylation diminishes BMP2-induced expression of GATA binding protein 4 and myocyte enhancer factor (MEF)2C in cardiac myocytes. PMID: 23632743
  27. incorporation of nanostructured colloidal gelatin gels capable of time- and dose-controlled delivery of BMP-2 and FGF-2 in porous titanium scaffolds is a promising strategy to enhance and continue bone regeneration of large bone defects. PMID: 23822814
  28. Ectopic bone formation assays at subcutaneous sites in rats demonstrated that HA hydrogel-delivered BMP-2 precomplexed with GAG induced twice the volume of bone compared with BMP-2 delivered uncomplexed to GAG. PMID: 24167632
  29. The study provides novel evidence that 1,25-dihydroxyvitamin D3 represses bone formation through down-regulating BMP2 expression both in vivo and in vitro. PMID: 23620751
  30. Gene transfer of the calcification inducer BMP2 gene to the trabecular meshwork induces elevated IOP in living rats without altering the basic structure of the tissue. PMID: 23821199
  31. Quantitative real-time PCR (RT-qPCR) and enzyme-linked immunosorbent assay (ELISA) demonstrated that lyophilized BMP-2/CDHA construct with trehalose (lyo-tre-BMP-2) promoted osteogenic differentiation of bone marrow stromal cells (bMSCs) signific PMID: 23359400
  32. Mechanical loading further enhanced the efficacy of BMP2 application evidenced by increased mineralized tissue volume and mineralization at the stage of bony callus bridging. PMID: 22861354
  33. Therefore, cell-specific ECMs are capable of modulating the BMP-2-induced osteogenic and chondrogenic differentiation of hMSCs. PMID: 23088504
  34. Overall, the results demonstrated that the combination of injectable nCS/A paste and BMP2-gene-modified MSCs is a new and effective strategy for the repair of bone defects. PMID: 22994418
  35. BMP2 participates in regulating Ca(2+) signaling in pulmonary arterial smooth muscle cells by inhibiting TRPC1, TRPC4, and TRPC6 expression. PMID: 23447035
  36. The effect of BMP-2 on tendon derived stem cells might provide insights into the histopathological changes of tendinopathy. PMID: 23238867
  37. SHP is a downstream factor of BMP2 signaling in odontoblasts and may stimulate dentin matrix mineralization via enhancing the transcriptional activity of Dlx5. PMID: 23010719
  38. BMP2 and BMP7 have roles in inflammation, but BMP7 has a greater role in soft tissue edema PMID: 22674456
  39. analysis of a new approach to promote bone formation using an improved delivery system of bone morphogenetic protein-2 PMID: 22556155
  40. demonstrates that the combination of Wnt11 and BMP-2 effectively promotes cardiomyogenic differentiation of BM-MSCs in vitro. The synergistic effect of Wnt11 and BMP-2 on the cardiomyogenic differentiation of BM-MSCs is further enhanced in myocardium PMID: 22829700
  41. Diabetes is associated with an abnormal BMP/MAD homolog Smad signaling expression in the myenteric ganglia that affects the homeostasis of the enteric plexus. PMID: 21737358
  42. BMP-2 suppresses renal interstitial fibrosis by regulating epithelial-mesenchymal transition PMID: 21590708
  43. It contributes to aortic valve caldification in aged rats. PMID: 21157119
  44. Bone morphogenetic protein-2 binds to cartilage oligomeric matrix protein, resulting in inhibition of vascular smooth muscle calcification. PMID: 21350216
  45. These results suggest that SDF-1 increases the number of osteoprogenitor cells that are mobilized from the bone marrow and then home to the implant. PMID: 21043834
  46. Simvastatin increased the expression of BMP2 in the periodontal tissue after orthodontic tooth movement. PMID: 18380969
  47. Activation of BMP-2 expression in tendon derived stem cells during tendon overuse might provide a possible explanation of ectopic calcification in calcifying tendinopathy PMID: 20882582
  48. This study indicated that BMP2 is more widely expressed throughout the adult CNS than previously reported, and its continued abundant expression in the adult brain strongly supports the idea that BMP2 also plays pivotal roles in the adult brain. PMID: 20886619
  49. Down-regulation of IL-1beta is associated with cartilage repair in the pathological features of osteoarthritis. PMID: 20939479
  50. Chronic hypoxia induced an increased expression of BMP-2 in endothelial cells. BMP-2 may play an important role in the pathogenesis of hypoxic pulmonary hypertension. PMID: 18070548

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Subcellular Location Secreted
Protein Families TGF-beta family
Tissue Specificity Expressed in femur, calvaria, trachea, lung and ovary.
Database Links

KEGG: rno:29373

STRING: 10116.ENSRNOP00000028904

UniGene: Rn.90931

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