Recombinant Rat Dynamin-1 (Dnm1), partial

1. Dynamin was identified as a septin-binding protein within neuronal membrane raft. PMID: 23260429
2. Compared to endophilinI/II, the interaction between dynamin I and endophilin III is significantly increased in clathrin-mediated endocytosis. PMID: 22961472
3. Phosphorylation and nitration of tyrosine residues affect functional properties of Synaptophysin and Dynamin I. PMID: 23103755
4. EHD1 inhibits dynamin-induced membrane tubulation in the presence of GTPgammaS, a phenomenon linked with dynamin helix assembly in synaptic vesicles. PMID: 21957258
5. Ca(2+) influx regulates assembly of a fully active CaN-calmodulin complex selectively on the tail of dynIxb and the complex is recruited to sites of activity-dependent bulk endocytosis in nerve terminals PMID: 21730063
6. In a rat model of Alzheimer's disease, a decrease of dynamin I in hippocampal neurons is found at protein and mRNA levels. PMID: 20847448
7. The deformation dynamics of dynamin is dominated by the draining of the membrane out of the helix, allowing quantification of helix-membrane interactions. PMID: 21112282
8. Study found that the specific phosphorylation of Ser-774 on dynamin I by glycogen synthase kinase 3 was both necessary and sufficient for activity-dependent bulk endocytosis. PMID: 20526333
9. These findings suggest that evoked synchronous and asynchronous release originate from the same vesicle pool that recycles rapidly in a dynamin-dependent manner; a distinct vesicle pool sustains spontaneous release independent of dynamin activation. PMID: 20107062
10. developed a theory based on the competition between dynamin polymerization and membrane mechanical deformation. This curvature control of dynamin polymerization is predicted for a specific range of concentrations, which corresponds to our measurements PMID: 20160074
11. couples endocytosis and exocytosis PMID: 11856729
12. Mnbk/Dyrk1A plays a dual role in regulating the interaction of dynamin 1 with amphiphysin 1. Phosphorylation reduced the interaction of dynamin with endophilin 1,the same phosphorylation enhanced the binding of dynamin 1 to Grb2; important to endocytosis. PMID: 11877424
13. demonstrate that phosphorylation of dynamin I by c-Src induces its self-assembly and increases its GTPase activity PMID: 12011079
14. Results of dynamin 1 mutants study offer direct evidence that supports the conclusion that fast site Ser-857 phosphorylation causes reduction in the level of binding of dynamin 1 to amphiphysin 1 and directly contributes to enhanced Grb 2 binding. PMID: 15287745
15. Interaction with phospholipase D2 may be involved in enzyme activation. PMID: 15581494
16. Dynamin 1 is a novel dystroglycan-associated protein. PMID: 15728588
17. results support a model in which switch I residue Arg-59 gates GTP binding in an assembly-dependent manner and the GTPase effector domain functions as an assembly-dependent GTPase activating protein in the fashion of RGS-type GAPs. PMID: 16141317
18. dynamin 1 degradation was the result of calpain activation induced by the sustained calcium influx mediated by N-methyl-D-aspartate receptors in hippocampal neurons. PMID: 16864575
19. Because syndapin acts as a phospho-sensor, this supports its role in depolarization-induced SVE at the synapse, which involves dynamin dephosphorylation. PMID: 17437541
20. Amyloid-beta caused a disruption of synaptic vesicle endocytosis in cultured hippocampal neurons; evidence suggests Abeta-induced dynamin 1 depletion plays a role in this process. PMID: 17499934
21. SNX9 interacts with dynamin-1 and N-WASP in presynaptic terminals, where it links actin dynamics and synaptic vesicle endocytosis. PMID: 17681954
22. The tandem SH3A and SH3B domains of Tks5 constitute a versatile module for the implementation of isoform-specific protein-protein interactions. PMID: 19464300

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KEGG: rno:140694

STRING: 10116.ENSRNOP00000047444

UniGene: Rn.10354