Recombinant Rat E3 ubiquitin-protein ligase XIAP(Xiap)

Product Type Recombinant Protein
Uniprot No. Q9R0I6
Abbreviation Xiap
Species Rattus norvegicus (Rat)
Gene Names Xiap
Protein Names Recommended name: E3 ubiquitin-protein ligase XIAP EC= 6.3.2.- Alternative name(s): Baculoviral IAP repeat-containing protein 4 IAP homolog A Inhibitor of apoptosis protein 3 Short name= IAP-3 Short name= rIAP-3 Sh
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Target Details This protein is a member of a family of proteins which inhibit apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. This protein inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. It also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.
Function Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include
Subcellular Location Cytoplasm, Nucleus
Protein Families IAP family
Database Links

KEGG: rno:63879

STRING: 10116.ENSRNOP00000009336

UniGene: Rn.91239

Pathway Focal adhesion
NF-kappa B signaling pathway
Apoptosis
Necroptosis
Ubiquitin mediated proteolysis
NOD-like receptor signaling pathway

Product Details for Different Expression Systems

Product Name Recombinant Rat E3 ubiquitin-protein ligase XIAP(Xiap),Yeast
Code CSB-YP865627RA
Size Pls inquiry other sizes
Source Yeast
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MTFNSFEGSR TVVPADTNKD EEFVEEFNRL KTFANFPSSS PVSASTLARA GFLYTGEGDT VQCFSCHAAV DRWQYGDSAV GRHRRISPNC RFINGFYFEN GATQSTSPGI QNGQYKSENC VGNRNHFALD RPSETHADYL LRTGQVVDIS DTIYPRNPAM CSEEARLKTF QNWPDYAHLS PRELASAGLY YTGIDDQVQC FCCGGKLKNW EPCDRAWSEH RRHFPNCFFV LGRNVNVRSE SGVSSDRNFP NSTNSPRNPA MAEYDARIVT FGTWLYSVNK EQLARAGFYA LGEGDKVKCF HCGGGLTDWK PSEDPWEQHA KWYPGCKYLL DEKGQEYINN IHLTHSLGES VVRTAEKTPS VTKKIDDTIF QNPMVQEAIR MGFNFKDIKK TMEEKLQTSG SNYLSLEVLI ADLVSAQKDN SQDESSQTSL QKDISTEEQL RRLQEEKLCK ICMDRNIAIV FVPCGHLVTC KQCAEAVDKC PMCCTVITFK QKIFMS
Expression Region 1-496
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
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Product Name Recombinant Rat E3 ubiquitin-protein ligase XIAP(Xiap),E.coli
Code CSB-EP865627RA
Size Pls inquiry other sizes
Source E.coli
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-SUMO-tagged and C-terminal Myc-tagged
N-terminal His-B2M-tagged and C-terminal Myc-tagged
N-terminal His-GST-tagged and C-terminal Myc-tagged
N-terminal His-tagged
N-terminal His-SUMO-tagged
N-terminal His-B2M-tagged
N-terminal His-GST-tagged
N-terminal GST-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MTFNSFEGSR TVVPADTNKD EEFVEEFNRL KTFANFPSSS PVSASTLARA GFLYTGEGDT VQCFSCHAAV DRWQYGDSAV GRHRRISPNC RFINGFYFEN GATQSTSPGI QNGQYKSENC VGNRNHFALD RPSETHADYL LRTGQVVDIS DTIYPRNPAM CSEEARLKTF QNWPDYAHLS PRELASAGLY YTGIDDQVQC FCCGGKLKNW EPCDRAWSEH RRHFPNCFFV LGRNVNVRSE SGVSSDRNFP NSTNSPRNPA MAEYDARIVT FGTWLYSVNK EQLARAGFYA LGEGDKVKCF HCGGGLTDWK PSEDPWEQHA KWYPGCKYLL DEKGQEYINN IHLTHSLGES VVRTAEKTPS VTKKIDDTIF QNPMVQEAIR MGFNFKDIKK TMEEKLQTSG SNYLSLEVLI ADLVSAQKDN SQDESSQTSL QKDISTEEQL RRLQEEKLCK ICMDRNIAIV FVPCGHLVTC KQCAEAVDKC PMCCTVITFK QKIFMS
Expression Region 1-496
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Rat E3 ubiquitin-protein ligase XIAP(Xiap),Baculovirus
Code CSB-BP865627RA
Size Pls inquiry other sizes
Source Baculovirus
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MTFNSFEGSR TVVPADTNKD EEFVEEFNRL KTFANFPSSS PVSASTLARA GFLYTGEGDT VQCFSCHAAV DRWQYGDSAV GRHRRISPNC RFINGFYFEN GATQSTSPGI QNGQYKSENC VGNRNHFALD RPSETHADYL LRTGQVVDIS DTIYPRNPAM CSEEARLKTF QNWPDYAHLS PRELASAGLY YTGIDDQVQC FCCGGKLKNW EPCDRAWSEH RRHFPNCFFV LGRNVNVRSE SGVSSDRNFP NSTNSPRNPA MAEYDARIVT FGTWLYSVNK EQLARAGFYA LGEGDKVKCF HCGGGLTDWK PSEDPWEQHA KWYPGCKYLL DEKGQEYINN IHLTHSLGES VVRTAEKTPS VTKKIDDTIF QNPMVQEAIR MGFNFKDIKK TMEEKLQTSG SNYLSLEVLI ADLVSAQKDN SQDESSQTSL QKDISTEEQL RRLQEEKLCK ICMDRNIAIV FVPCGHLVTC KQCAEAVDKC PMCCTVITFK QKIFMS
Expression Region 1-496
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat
Product Name Recombinant Rat E3 ubiquitin-protein ligase XIAP(Xiap),Mammalian cell
Code CSB-MP865627RA
Size Pls inquiry other sizes
Source Mammalian cell
Purity >85% (SDS-PAGE)
Tag Info The following tags are available.
N-terminal His-tagged and C-terminal Myc-tagged
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Sequence MTFNSFEGSR TVVPADTNKD EEFVEEFNRL KTFANFPSSS PVSASTLARA GFLYTGEGDT VQCFSCHAAV DRWQYGDSAV GRHRRISPNC RFINGFYFEN GATQSTSPGI QNGQYKSENC VGNRNHFALD RPSETHADYL LRTGQVVDIS DTIYPRNPAM CSEEARLKTF QNWPDYAHLS PRELASAGLY YTGIDDQVQC FCCGGKLKNW EPCDRAWSEH RRHFPNCFFV LGRNVNVRSE SGVSSDRNFP NSTNSPRNPA MAEYDARIVT FGTWLYSVNK EQLARAGFYA LGEGDKVKCF HCGGGLTDWK PSEDPWEQHA KWYPGCKYLL DEKGQEYINN IHLTHSLGES VVRTAEKTPS VTKKIDDTIF QNPMVQEAIR MGFNFKDIKK TMEEKLQTSG SNYLSLEVLI ADLVSAQKDN SQDESSQTSL QKDISTEEQL RRLQEEKLCK ICMDRNIAIV FVPCGHLVTC KQCAEAVDKC PMCCTVITFK QKIFMS
Expression Region 1-496
Protein Description full length protein
Storage Buffer Tris-based buffer,50% glycerol
Still Have Questions? Leave a Message or Start an on-line Chat

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